Transient receptor potential (TRP) V3 is a thermosensitive ion channel expressed predominantly in the skin and neural tissues. It activated by warmth monoterpene camphor has been hypothesized to be involved sensitization. A selection of monoterpenoid compounds was tested for TRPV3 activation establish structure-function relationship. The related TRPM8 cool temperatures number chemicals, among them (-)-menthol. overlap pharmacology between two channels investigated.Transfected HEK293 cells...

Transient receptor potential melastatin-8 (TRPM8) is an ion channel expressed extensively in sensory nerves, human prostate and overexpressed a variety of cancers including prostate, breast, lung, colon skin melanomas. It activated by innoxious cooling chemical stimuli. TRPM8 activation or agonists reported to induce profound analgesia neuropathic pain conditions. Known like menthol icilin cross-activate other thermo-TRP channels TRPV3 TRPA1 mutually inhibit TRPM8. This limits the usefulness...

Transient receptor potential vanilloid-3 (TRPV3) is a thermo-sensitive ion channel expressed in skin keratinocytes and variety of neural cells. It activated by warmth as well monoterpenoids including camphor, menthol, dihydrocarveol 1,8-cineol. TRPV3 described putative nociceptor previous studies revealed sensitization the during repeated short-term stimulation with different agonists. In present investigation was transiently either Xenopus oocytes or HEK293 Whole-cell voltage-clamp...

Transient receptor potential vanilloid subtype 3 (TRPV3) is a thermosensitive ion channel expressed in variety of neural cells and keratinocytes. It activated by warmth (33–39°C), its responsiveness dramatically increased at nociceptive temperatures greater than 40°C. Monoterpenoids 2-APB are chemical activators TRPV3 channels. We found that Icilin, known cooling substance putative ligand TRPM8, reversibly inhibits activity nanomolar concentrations expression systems like Xenopus laeves...

Parasitic Cuscuta reflexa Roxb. possesses many medicinal properties and is a rich source of variety biologically relevant natural products. Natural products are the prime leads, drugs, drug templates, anticancer antiviral drugs either based on product or derived from them. Cancer devastating disease one leading causes death worldwide despite improvements in patient survival during past 50 years; new improved treatments for cancer therefore actively sought. Colorectal fourth most prevalent...

Norepinephrine, is involved in the enhancement of learning and memory formation by regulating synaptic mechanisms through its ability to activate pre- post-synaptic adrenergic receptors. Here we show that β-agonists norepinephrine facilitate induction both associational LTP sharp wave ripples (SPW-Rs) acute slices rat hippocampus area CA3. Surprisingly, this facilitating effect persists when are only pretreated with β-receptor agonists followed wash out application unspecific...

Antitussive effects of ethyl acetate fraction Terminalia chebula on sulphur dioxide (SO2) gas induced cough have been examined in mice. Safety profile was established by determining LD50 and acute neurotoxicity. The result showed that extract dose dependently suppressed SO2 chebula, after i.p. administration at level 500 mg/kg, offered maximum suppressive effects; is, number coughs 60 min 12 ± 1.52 (mean SEM) as compared to codeine 10 mg/kg; i.p., dextromethorphan saline, having frequency...

Herein, we report the green synthesis of silver nanoparticles using aqueous extract root Angilica glauca Edgew. UV-vis and FT-IR spectroscopies, X-ray diffraction analysis scanning electron microscopy technique were employed to structurally morphologically characterize synthesized nanoparticles. The found be spherical in shape with an average size ∼21 nm. was rich phenolic flavonoid contents. Both extract-loaded inhibited growth both Pseudomonas aeruginosa (inhibition zone 13.0 ± 1.6 4.0 0.9...

Forty-seven million people are living with memory-related disorders worldwide. Phytomedicines gaining extensive interest in the treatment of these ailments. Memory-enhancing (acute and chronic) potentials commercial grade extracts Bacopa monnieri (200 mg/kg, po), Ginkgo biloba (150 Lavandula angustifolia po) their mixture (B. 100 G. 75 L. were compared for synergistic/additive effects on Morris water maze (MWM) test elevated plus (EPM) scopolamine-induced amnesia mice. Escape latency...

We studied the metal contaminations as well antimicrobial and antioxidant activities of five medicinal species: Berberis lyceum (Sumbal), Datura stramonium (Joz-e-masel), Semicarpous anacardium (Bhalawa), Fumaria indica (Shahtara) Gymnema sylvestre (Gurmar) using atomic absorption spectrophotometry agar-well diffusion method against E. coli S. aureus ABTS+● decolorization assay. found that contamination levels K, Ca, Mg, Ni are above standard permissible limits should be monitored. B. has...

Abstract Mental and neurological diseases including depression, Parkinson’s disease, dementia, epilepsy, anxiety disorders bipolar account for a considerable amount of the world’s disease burden. Unfortunately, drugs used in treatment are expensive, symptomatic they produce undesirable side effects. People from different cultures prefer to use medicinal plants various ailments ranging plain perplex because most affordable, cost effective easily accessible source primary healthcare system...

The nutritional status and ethnic-aloofness (non mixed genomes owing to lack of cross marriages) might have direct impact on the average age quality health individuals belonging different racial groupings. North Western region Balochistan around Quetta, Pakistan, has diverse ethnic populations which afford a unique genomic pattern in addition specific life style, eating, health. biological correlation this demography is expected reflect overall an individual. 100 subjects each population...

The current study has reported the silver-nanoparticle’s green synthesis of silver-nanoparticles using silver ions from nitrate and by aqueous-root-extract R. nepalensis. Initial clue Ag-nanoparticles (AgNPs) formation was change in color solution light brown to grey followed broad band UV-Visible spectrum obtained at 447 nm. Average size resulting AgNPs 17.15 nm X-Ray Diffraction (XRD) confirmed their crystalline cubic structure. SEM showed high intensity, spherical shaped addition some...