A5048481898- Olfactory and Sensory Function Studies
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Mast cells and histamine
- Neurotransmitter Receptor Influence on Behavior
- Aldose Reductase and Taurine
- Ion channel regulation and function
- Pain Mechanisms and Treatments
- Ion Channels and Receptors
- Diet and metabolism studies
- Metabolomics and Mass Spectrometry Studies
- Neuroendocrine regulation and behavior
- Pancreatic function and diabetes
- Multisensory perception and integration
- Sleep and Wakefulness Research
- Nicotinic Acetylcholine Receptors Study
- Vestibular and auditory disorders
- Adipose Tissue and Metabolism
- Tactile and Sensory Interactions
- Biochemical Analysis and Sensing Techniques
- Cholinesterase and Neurodegenerative Diseases
- Diabetes Treatment and Management
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
Heinrich Heine University Düsseldorf
2013-2023
Düsseldorf University Hospital
2015
Ruhr University Bochum
2008-2013
Astringency is an everyday sensory experience best described as a dry mouthfeel typically elicited by phenol-rich alimentary products like tea and wine. The neural correlates cellular mechanisms of astringency perception are still not well understood. We explored taste in human subjects to study the contribution trigeminal system perception. Subjects with either lesion or lidocaine anesthesia Chorda tympani nerve showed no impairment Only both lingual innervation inferior alveolar block led...
Histamine is not only a crucial cytokine in the periphery but also an important neurotransmitter and neuromodulator brain. It known to act on metabotropic H1-H4 receptors, existence of directly histamine-gated chloride channels mammals has been suspected for many years. However, molecular basis such mammalian remained elusive, whereas invertebrates, genes have already identified. In this report, we demonstrated that histamine can open vertebrate ion identified β subunits GABAA receptors as...
Transient receptor potential vanilloid-3 (TRPV3) is a thermo-sensitive ion channel expressed in skin keratinocytes and variety of neural cells. It activated by warmth as well monoterpenoids including camphor, menthol, dihydrocarveol 1,8-cineol. TRPV3 described putative nociceptor previous studies revealed sensitization the during repeated short-term stimulation with different agonists. In present investigation was transiently either Xenopus oocytes or HEK293 Whole-cell voltage-clamp...
Nineteen GABA(A) receptor (GABA(A)R) subunits are known in mammals with only a restricted number of functionally identified native combinations. The physiological role beta1-subunit-containing GABA(A)Rs is unknown. Here we report the discovery new structural class GABA(A)R positive modulators unique beta1-subunit selectivity: fragrant dioxane derivatives (FDD). At heterologously expressed alpha1betaxgamma2L (x-for 1,2,3) FDD were 6 times more potent at beta1- versus beta2- and...
Taurine is a semi-essential sulfonic acid found at high concentrations in plasma and mammalian tissues which regulates osmolarity, ion channel activity glucose homeostasis. The structural requirements of GABAA-receptors (GABAAR) gated by taurine are not yet known. We determined potency efficacy relative to GABA different types recombinant GABAAR occurring central histaminergic neurons the mouse hypothalamic tuberomamillary nucleus (TMN) controls arousal. At binary α1/2β1/3 receptors was as...
The histaminergic tuberomamillary nucleus (TMN) of the posterior hypothalamus controls cognitive aspects vigilance which is reduced by common sedatives and anxiolytics. receptors targeted these drugs in neurons are unknown. TMN express nine different subunits GABAA receptor (GABAA R) with three α- (α1, α2 α5) two γ- (γ1, γ 2) subunits, confer pharmacologies benzodiazepine-binding site.We investigated actions zolpidem, midazolam, diazepam, chlordiazepoxide, flumazenil (Ro15-1788)...
Neuropathic pain affects up to 10% of the global population and is caused by an injury or a disease affecting somatosensory, peripheral, central nervous system. NP characterized chronic, severe opioid-resistant properties. Therefore, its clinical management remains very challenging. The N-type voltage-gated calcium channel, Ca
Abstract The hyperpolarization-activated cation current I f is a key determinant for cardiac pacemaker activity. It conducted by subunits of the cyclic nucleotide–gated (HCN) channel family, which HCN4 predominant in mammalian heart. Both loss-of-function and gain-of-function mutations gene are associated with sinus node dysfunction humans; however, their functional impact not fully understood yet. Here, we sought to characterize V759I variant detected patient family history sick syndrome....
NMDA receptor dependent anti-diabetic effects Jan Marquard, Silke Otter, Alena Welters, Diran Herebian, Fatih Demir, Annett Schroeter, Olaf Kletke, Martin Kragl, Daniel Eberhard, Barbara Bartosinska, Masa Skelin Klemen, Andraz Stozer, Kohler, Alin Stirban, Freimut Schliess, Tim Heise, Stephan Wnendt, Marjan Slak Rupnik, Per-Olof Berggren, Nikolaj Klocker, Thomas Meissner, Ertan Mayatepek, Eckhard Lammert