A5003433942- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diabetes Management and Research
- Medical and Health Sciences Research
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Medical Practices and Rehabilitation
- Metabolism and Genetic Disorders
- Health and Medical Studies
- Diabetes Treatment and Management
- Biomedical and Chemical Research
- Social and Demographic Issues in Germany
- German Literature and Culture Studies
- Medical History and Research
- Bladder and Urothelial Cancer Treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Psychosomatic Disorders and Their Treatments
- Neonatal Respiratory Health Research
- Pediatric health and respiratory diseases
- Adolescent and Pediatric Healthcare
- Clinical practice guidelines implementation
- Respiratory Support and Mechanisms
- Pharmaceutical studies and practices
- Diet and metabolism studies
- Asthma and respiratory diseases
- Migraine and Headache Studies
Josef Meissner (Germany)
2014-2024
Heinrich Heine University Düsseldorf
2015-2024
Düsseldorf University Hospital
2015-2024
Babeș-Bolyai University
2023
Leipzig University
2009-2022
KU Leuven
2022
Springer Nature (Germany)
2021
Thüringer Aufbaubank
2013-2020
Beiersdorf (Germany)
2020
German Center for Diabetes Research
2016-2019
BACKGROUND: The term congenital hyperinsulinism (CHI) comprises a group of different genetic disorders with the common finding recurrent episodes hyperinsulinemic hypoglycemia. OBJECTIVE: To evaluate clinical presentation, diagnostic criteria, treatment and long-term follow-up in large cohort CHI patients. PATIENTS: data from 114 patients hospitals were obtained by detailed questionnaire. Patients presented neonatally (65%), during infancy (28%) or childhood (7%). RESULTS: In 20 74 (27%)...
Abstract Background Propionic acidemia is an inherited disorder caused by deficiency of propionyl-CoA carboxylase. Although it one the most frequent organic acidurias, information on outcome affected individuals still limited. Study design/methods Clinical and data 55 patients with propionic from 16 European metabolic centers were evaluated retrospectively. 35 diagnosed selective screening while 20 identified newborn screening. Endocrine parameters bone age evaluated. In addition, IQ testing...
Abstract The incidence of type 1 diabetes (T1D) has substantially increased over the past decade, suggesting a role for non-genetic factors such as epigenetic mechanisms in disease development. Here we present an epigenome-wide association study across 406,365 CpGs 52 monozygotic twin pairs discordant T1D three immune effector cell types. We observe substantial enrichment differentially variable CpG positions (DVPs) twins when compared with their healthy co-twins and healthy, unrelated...
To explore the acceptance of uncoated drug-free mini-tablets 2 mm in diameter children aged 0.5-6 years and their ability to swallow mini-tablets.60 (10 subjects per year life) were enrolled our prospective, open random, two-way cross-over exploratory pilot study. The administered either an mini-tablet with a beverage choice or 3 ml glucose syrup 15% followed by other formulation. Deglutition was visually assessed for two different dosage forms using predefined criteria list.The study...
<b><i>Background:</i></b> Hyperinsulinism (HI) due to dysregulation of pancreatic beta-cell insulin secretion is the most common and severe cause persistent hypoglycemia in infants children. In 65 years since HI children was first described, there has been a dramatic advancement diagnostic tools available, including new genetic techniques novel radiologic imaging for focal HI; however, have almost no therapeutic modalities development diazoxide....
Importance The circumstances under which neonatal hypoglycemia leads to brain damage remain unclear due a lack of long-term data on the neurodevelopment affected children. As result, diagnostic strategies and treatment recommendations are inconsistent. Objective To evaluate whether occurrence severe transitional (defined as having at least 1 blood glucose measurement 30 mg/dL or below) is associated with adverse in midchildhood. Design, Setting, Participants This cohort study using...