A5064226008- Olfactory and Sensory Function Studies
- Biochemical Analysis and Sensing Techniques
- Neurobiology and Insect Physiology Research
- Advanced Chemical Sensor Technologies
- Ion Channels and Receptors
- Neuroendocrine regulation and behavior
- Vestibular and auditory disorders
- RNA Research and Splicing
- Tactile and Sensory Interactions
- Virus-based gene therapy research
- Molecular Biology Techniques and Applications
- Multisensory perception and integration
University of Bonn
2022
Northwestern University
2017-2021
RWTH Aachen University
2012-2015
Astringency is an everyday sensory experience best described as a dry mouthfeel typically elicited by phenol-rich alimentary products like tea and wine. The neural correlates cellular mechanisms of astringency perception are still not well understood. We explored taste in human subjects to study the contribution trigeminal system perception. Subjects with either lesion or lidocaine anesthesia Chorda tympani nerve showed no impairment Only both lingual innervation inferior alveolar block led...
Abstract In many species, survival depends on olfaction, yet the mechanisms that underlie olfactory sensitivity are not well understood. Here we examine how a conserved subset of receptors, trace amine-associated receptors (TAARs), determine odor detection thresholds mice to amines. We find deleting all TAARs, or even single results in significant deficits. This finding is limited as deletion canonical odorant receptor reduced behavioral its preferred ligand. Remarkably, threshold set solely...
Olfactory inputs are organized in an array of functional units (glomeruli), each relaying information from sensory neurons expressing a given odorant receptor to small population output neurons, mitral/tufted (MT) cells. MT cells respond heterogeneously odorants, and how the responses encode stimulus features is unknown. We recorded awake mice "sister" that receive input functionally characterized, genetically identified glomerulus, corresponding specific (M72). Despite receiving similar...
The mouse vomeronasal organ (VNO) plays a critical role in semiochemical detection and social communication. Vomeronasal stimuli are typically secreted various body fluids. Following direct contact with urine deposits or other secretions, peristaltic vascular pump mediates fluid entry into the recipient's VNO. Therefore, while sensory neurons (VSNs) sample stimulatory semiochemicals dissolved intraluminal mucus, they might also be affected by general physicochemical properties of “solvent.”...
Intracellular Cl− concentrations ([Cl−]i) of sensory neurons regulate signal transmission and amplification. In dorsal root ganglion (DRG) olfactory (OSNs), is accumulated by the Na+-K+-2Cl− cotransporter 1 (NKCC1), resulting in a [Cl−]i above electrochemical equilibrium depolarizing efflux upon channel opening. Here, we investigate function primary trigeminal ganglia (TG) wild type (WT) NKCC1−/− mice using pharmacological imaging approaches, patch-clamping, as well behavioral testing. The...
Abstract In order to survive, an organism has adapt its behavioral actions the current context by carefully balancing sensory input with physiological state and need. This challenge becomes particularly apparent for olfactory stimuli (volatile chemicals), which can signal not only food sources, mating partners, offspring, but also pathogens, competitors, predators. To achieve this difficult task, information processing in system is strongly modulated internal (for example, metabolic or...
Abstract Olfactory inputs are organized in an array of parallel functional units (glomeruli), each relaying information from sensory neurons that express a given odorant receptor to small population output neurons, mitral/tufted (MT) cells. MT cells have complex temporal responses odorants, but how these diverse relate stimulus features is not known. We recorded awake mice “sister” receive input functionally-characterized, genetically identified glomerulus, corresponding specific (M72)....
A bstract While the olfactory system is required for proper social behaviors, molecular basis how cues are detected via main pathway of mammals not well-characterized. Trimethylamine a volatile, sex-specific odor found in adult male mouse urine that selectively activates sensory neurons express trace amine-associated receptor 5 (TAAR5). Here we show trimethylamine, acting TAAR5, elicits state-dependent attraction or aversion mice and drives inter-male aggression. Genetic knockout TAAR5...
ABSTRACT In many species, survival depends on olfaction, yet the mechanisms that underlie olfactory sensitivity are not well understood. Here, we examine how a conserved subset of receptors, trace amine-associated receptors (TAARs) determine odor detection thresholds mice to amines. We find deleting all TAARs, or even single results in significant deficits. This finding is limited as deletion canonical odorant receptor reduced behavioral its preferred ligand. Remarkably, threshold set solely...