A5078890649- Diphtheria, Corynebacterium, and Tetanus
- Mycobacterium research and diagnosis
- RNA and protein synthesis mechanisms
- Genomics and Phylogenetic Studies
- Bacterial Identification and Susceptibility Testing
- Bacteriophages and microbial interactions
- IPv6, Mobility, Handover, Networks, Security
- Antibiotic Resistance in Bacteria
- Legionella and Acanthamoeba research
- Probiotics and Fermented Foods
- Veterinary medicine and infectious diseases
- Microbial Metabolic Engineering and Bioproduction
- Microbial infections and disease research
- vaccines and immunoinformatics approaches
- Microbial Natural Products and Biosynthesis
- Toxin Mechanisms and Immunotoxins
- Streptococcal Infections and Treatments
- Salmonella and Campylobacter epidemiology
- Bioinformatics and Genomic Networks
- Neonatal and Maternal Infections
- Computational Drug Discovery Methods
- Biochemical and Structural Characterization
- Antimicrobial Resistance in Staphylococcus
- Oral microbiology and periodontitis research
- Urinary Tract Infections Management
University of Karachi
2021-2024
International Center for Chemical and Biological Sciences
2021-2024
Islamia College University
2017-2024
Institute of Electrical and Electronics Engineers
2021-2024
Virginia Tech
2021-2024
King Abdulaziz University
2016-2024
Fundação Oswaldo Cruz
2022-2024
COMSATS University Islamabad
2022
Universidade Federal de Minas Gerais
2012-2019
University of Peshawar
2008
Corynebacterium pseudotuberculosis is a facultative intracellular pathogen and the causative agent of several infectious contagious chronic diseases, including caseous lymphadenitis, ulcerative lymphangitis, mastitis, edematous skin disease, in broad spectrum hosts. In addition, infections pose rising worldwide economic problem ruminants. The complete genome sequences 15 C. strains isolated from different hosts countries were comparatively analyzed using pan-genomic strategy. Phylogenomic,...
Vibrio cholerae is the causal organism of cholera epidemic, which mostly prevalent in developing and underdeveloped countries. However, incidences developed countries are also alarming. Because emergence new drug-resistant strains, even though several generic drugs vaccines have been over time, infections remain a global health problem that appeals for development novel against pathogen. Here, applying comparative proteomic reverse vaccinology approaches to exoproteome secretome pathogen, we...
Corynebacterium pseudotuberculosis (Cp) is a pathogenic bacterium that causes caseous lymphadenitis (CLA), ulcerative lymphangitis, mastitis, and edematous to broad spectrum of hosts, including ruminants, thereby threatening economic dairy industries worldwide. Currently there no effective drug or vaccine available against Cp. To identify new targets, we adopted novel integrative strategy, which began with the prediction modelome (tridimensional protein structures for proteome an organism,...
Exiguobacterium antarcticum is a psychotropic bacterium isolated for the first time from microbial mats of Lake Fryxell in Antarctica. Many organisms genus are extremophiles and have properties biotechnological interest, e.g., capacity to adapt cold, which make this target discovering new enzymes, such as lipases proteases, addition improving our understanding mechanisms adaptation survival at low temperatures. This study presents genome E. B7, biofilm sample Ginger on King George Island,...
Helicobacter pylori is a human gastric pathogen implicated as the major cause of peptic ulcer and second leading cancer (~70%) around world. Conversely, an increased resistance to antibiotics hindrances in development vaccines against H. are observed. Pan-genome analyses global representative isolates consisting 39 complete genomes presented this paper. Phylogenetic have revealed close relationships among geographically diverse strains . The conservation these was further analyzed by...
The genus Campylobacter contains pathogens causing a wide range of diseases, targeting both humans and animals. Among them, the fetus subspecies venerealis deserve special attention, as they are etiological agents human bacterial gastroenteritis bovine genital campylobacteriosis, respectively. We compare whole genomes to get insights into genomic architecture, phylogenetic relationships, genome conservation core virulence factors. Pan-genomic approach was applied identify core- pan-genome...
The bacterium Corynebacterium pseudotuberculosis (Cp) causes caseous lymphadenitis (CLA), mastitis, ulcerative lymphangitis, and oedema in a number of hosts, comprising ruminants, thereby intimidating economic dairy industries worldwide. So far there is no effective drug or vaccine available against Cp. Previously, pan-genomic analysis was performed for both biovar equi ovis Pathogenicity Islands (PAIS) within the strains highlighted large set proteins that could be relevant therapeutic...
Infectious diseases have been tremendously increasing as the organisms of even normal flora become opportunistic and cause an infection, Escherichia coli ( E. EQ101) is one them. Urinary tract infections are caused by various microorganisms, but primary almost 70%–90% all UTIs. It has multiple strains, possessing diverse virulence factors, contributing to its pathogenicity. Furthermore, these virulent strains also can overlapping pathogenesis sharing resistance factors among each other. The...
Corynebacterium diphtheriae (Cd) is a Gram-positive human pathogen responsible for diphtheria infection and once regarded high mortalities worldwide. The fatality gradually decreased with improved living standards further alleviated when many immunization programs were introduced. However, numerous drug-resistant strains emerged recently that consequently the efficacy of current therapeutics vaccines, thereby obliging scientific community to start investigating new therapeutic targets in...
Streptococcus agalactiae (Lancefield group B; GBS) is the causative agent of meningoencephalitis in fish, mastitis cows, and neonatal sepsis humans. Meningoencephalitis a major health problem for tilapia farming responsible high economic losses worldwide. Despite its importance, genomic characteristics main molecular mechanisms involved virulence S. isolated from fish are still poorly understood. Here, we present features 1,820,886 bp long complete genome sequence SA20-06 outbreak Nile...
Automated and efficient methods that map ortholog interactions from several organisms public databases (pDB) are needed to identify new in an organism of interest (interolog mapping).
Lactococcus lactis subsp. NCDO 2118 is a nondairy lactic acid bacterium, xylose fermenter, and gamma-aminobutyric (GABA) producer isolated from frozen peas. Here, we report the complete genome sequence of L. 2118, strain with probiotic potential activity.
Abstract Typhoid fever is transmitted by ingestion of polluted water, contaminated food, and stool typhoid-infected individuals, mostly in developing countries with poor hygienic environments. To find novel therapeutic targets inhibitors, We employed a subtractive genomics strategy towards Salmonella Typhi the complete genomes eight strains were primarily subjected to EDGAR tool predict core genome ( n = 3207). Human non-homology 2450) was followed essential genes identification 37). The...
The Actinobacteria, Corynebacterium pseudotuberculosis strain P54B96, a nonmotile, non-sporulating and mesophile bacterium, was isolated from liver, lung mediastinal lymph node lesions in an antelope South Africa. This is interesting the sense that it has been found together with non-tuberculous mycobacteria (NTMs) which could nevertheless play role lesion formation. In this work, we describe set of features C. details complete genome sequence annotation. comprises 2.34 Mbp long, single...
streptococci) is a major pathogen that causes meningoencephalitis
Journal Article Conserved host–pathogen PPIs Globally conserved inter-species bacterial based host-pathogen interactome derived novel target in C. pseudotuberculosis, diphtheriae, M. tuberculosis, ulcerans, Y. pestis, and E. coli targeted by Piper betel compounds Get access Debmalya Barh, Barh Centre for Genomics Applied Gene Technology, Institute of Integrative Omics Biotechnology (IIOAB), Nonakuri, Purba Medinipur, West Bengal-721172, India. Fax: +91-944 955 0032; Tel: 0032Department...
Journal Article C. pseudotuberculosis Phop confers virulence and may be targeted by natural compounds Get access Sandeep Tiwari, Tiwari PG Program in Bioinformatics, Laboratory of Cellular Molecular Genetics (LGCM), Institute Biological Sciences, Federal University Minas Gerais, Belo Horizonte, MG, Brazil, vascoariston@gmail.com Email: sandip_sbtbi@yahoo.com Search for other works this author on: Oxford Academic Google Scholar Marcília Pinheiro da Costa, Costa Center Genomics State Ceará,...