A5066477233- Diphtheria, Corynebacterium, and Tetanus
- Mycobacterium research and diagnosis
- Probiotics and Fermented Foods
- Bacterial Identification and Susceptibility Testing
- Genomics and Phylogenetic Studies
- Gut microbiota and health
- Veterinary medicine and infectious diseases
- Antibiotic Resistance in Bacteria
- Bacteriophages and microbial interactions
- Salmonella and Campylobacter epidemiology
- Microbial Community Ecology and Physiology
- Streptococcal Infections and Treatments
- vaccines and immunoinformatics approaches
- Microbial Metabolites in Food Biotechnology
- Microbial infections and disease research
- Toxin Mechanisms and Immunotoxins
- Insect and Pesticide Research
- Insect and Arachnid Ecology and Behavior
- Bacterial biofilms and quorum sensing
- Microbial Metabolic Engineering and Bioproduction
- Brucella: diagnosis, epidemiology, treatment
- Melanoma and MAPK Pathways
- Reproductive tract infections research
- Clostridium difficile and Clostridium perfringens research
- Cancer Immunotherapy and Biomarkers
Universidade Federal de Minas Gerais
2016-2025
Microbiologie de l’alimentation au service de la santé
2022-2023
Universidade Federal do Pará
2019-2022
Virginia Tech
2017
Biocom
2017
Southwest Bahia State University
2011-2015
The number of genomes that have been deposited in databases has increased exponentially after the advent Next-Generation Sequencing (NGS), which produces high-throughput sequence data; this circumstance demanded development new bioinformatics software and creation areas, such as comparative genomics. In genomics, genetic content an organism is compared against other organisms, helps prediction gene function coding region sequences, identification evolutionary events determination...
Abstract In this study, we categorize the microbial community in mangrove sediment samples from four different locations within a vast system Kerala, India. We compared data to other taken known data, tropical rainforest, and ocean sediment. An examination of communities large forest that stretches across southwestern India showed strong similarities higher taxonomic levels. When single isolate rain were included analysis, pattern emerged with Bacteria phylum Proteobacteria being prominent...
9517 Background: Patients (pts) with melanoma who progress on anti–PD-1 therapy (anti–PD-1–failed) have limited treatment options. RP1 is an HSV-1–based oncolytic immunotherapy expressing human GM-CSF and a fusogenic protein (GALV-GP-R−). Here, we present data from pts anti–PD-1–failed melanoma, including the initial cohort updated registration-directed (R-D) cohort, phase 1/2 IGNYTE study (NCT03767348). Methods: Pts had locally advanced or metastatic cutaneous ≥1 measurable injectable tumor...
Methods based around statistics and linear algebra have been increasingly used in attempts to address emerging questions microarray literature. Microarray technology is a long-used tool the global analysis of gene expression, allowing for simultaneous investigation hundreds or thousands genes sample. It characterized by low sample size large feature number created non-square matrix, incomplete rank, that can generate countless more solution classifiers. To avoid problem 'curse...
The genus Pseudomonas includes metabolically versatile microorganisms occupying diverse niches, from environmental habitats to plant pathogens, and has clinically significant strains. For this reason, spp. might act as a reservoir of antimicrobial resistance genes, which have been detected even in isolated environments. aim study was report the susceptibility profile 25 fluorescens isolates soil samples collected on King George Island (Antarctic Peninsula), select non-clonal with unusual...
Introduction Next-generation sequencing (NGS) has played a pivotal role in the advancement of taxonomics, allowing for accurate identification, differentiation, and reclassification several bacteria species. Bacillus velezensis is Gram-positive, facultatively aerobic, spore-forming bacterium known its antimicrobial antifungal properties. Strains this species are highly relevant agriculture, biotechnology, food industry, biomedicine. Methods In study, we characterized genomes nine strains...
Corynebacterium diphtheriae (Cd) is a Gram-positive human pathogen responsible for diphtheria infection and once regarded high mortalities worldwide. The fatality gradually decreased with improved living standards further alleviated when many immunization programs were introduced. However, numerous drug-resistant strains emerged recently that consequently the efficacy of current therapeutics vaccines, thereby obliging scientific community to start investigating new therapeutic targets in...
Salmonella Typhimurium is associated with foodborne diseases worldwide, including in Peru, and its emerging antibiotic resistance (AMR) now a global public health problem. Therefore, country-specific monitoring of the AMR emergence vital to control this pathogen, these aspects, whole genome sequence (WGS)—based approaches are better than gene-based analyses. Here, we performed antimicrobial susceptibility test for ten widely used antibiotics WGS-based various analyses 90 S. isolates (human,...
Corynebacterium rouxii is one of the recently described species diphtheriae complex. As this can potentially infect different hosts and harbor tox gene, producing diphtheria toxin, we present its first pangenomic analysis in work. A total fifteen genomes deposited online databases were included. After confirming taxonomic position isolates by genomic taxonomy, submitted to plasticity, gene synteny, pangenome prediction analyses. In addition, virulence antimicrobial resistance genes...
Corynebacterium pseudotuberculosis is a Gram-positive, pleomorphic, facultative intracellular pathogen that causes Oedematous Skin Disease (OSD) in buffalo. To better understand the pathogenic mechanisms of OSD, we performed comparative genomic analysis 11 strains C. isolated from different buffalo found to be infected Egypt during an outbreak occurred 2008. Sixteen previously described pathogenicity islands (PiCp) were present all new strains, but one them, PiCp12, had insertion contained...
Seven genomes of Corynebacterium pseudotuberculosis biovar equi were sequenced on the Ion Torrent PGM platform, generating high-quality scaffolds over 2.35 Mbp. This bacterium is causative agent disease known as "pigeon fever" which commonly affects horses worldwide. The pangenome was calculated and two phylogenomic approaches used to identify clustering patterns within genus. Furthermore, other comparative analyses performed including prediction genomic islands prophages, SNP-based...
Abstract Introduction: ZN-c3 is a selective, orally bioavailable small molecule inhibitor of WEE1, crucial component the G2/M cell cycle checkpoint, which prevents cells from entering mitosis to allow repair DNA damage. has demonstrated significant in vitro antitumor activity multiple lines and xenograft models. Methods: ZN-c3-001 (NCT04158336) an open label, multicenter, Phase I dose escalation expansion study evaluating safety clinical subjects with advanced or metastatic solid tumors,...
Bifidobacterium breve is among the first microorganisms colonizing intestinal tract in humans and a predominant species gut microbiota of newborns children. This bacterium widely used probiotic industry due to its capacity improve host health. The search for new targets with properties an increasing trend help next-generation sequencing as they facilitate characterization bacterial features. B. 1101A was isolated from faeces healthy children Brazil therefore could play protective role gut....
Abstract Background Probiotics have gained attention for their potential maintaining gut and immune homeostasis. They been found to confer protection against pathogen colonization, possess immunomodulatory effects, enhance barrier functionality, mitigate inflammation. However, a thorough understanding of the unique mechanisms effects triggered by individual strains is necessary optimize therapeutic efficacy. Probiogenomics, involving high-throughput techniques, can help identify...
Corynebacterium silvaticum is a pathogenic, gram-positive bacterial species that causes caseous lymphadenitis in wild boars, domestic pigs and roe deer Western Europe. It can affect animal production cause zoonosis. Genome analysis has suggested one strain from Portugal Austria could probably produce the diphtheria toxin (DT), which inhibits protein synthesis death.To further investigate genetic diversity probable of DT by Portuguese strains, eight isolates this country were sequenced...
Abstract Most lactobacilli produce extracellular polysaccharides that are considered to contribute the probiotic effect of many strains. Lacticaseibacillus rhamnosus CNCM I-3690 is an anti-inflammatory strain able counterbalance gut barrier dysfunction. In this study ten spontaneous variants with different EPS-production were generated and characterized by their ropy phenotype, quantification secreted EPS genetic analysis. Amongst them, two further analysed in vitro vivo: over-producer...
Corynebacterium pseudotuberculosis is a pathogenic bacterium which has been rapidly spreading all over the world, causing economic losses in agricultural sector and sporadically infecting humans. Six C. strains were isolated from goats, sheep, horses with distinct abscess locations. For first time, Mexican genomes of this sequenced studied silico. All using Ion Personal Genome Machine sequencer, assembled Newbler SPAdes software. The automatic genome annotation was done software RAST...
Propionibacterium freudenreichii is a beneficial Gram-positive bacterium, traditionally used as cheese-ripening starter, and currently considered an emerging probiotic. As example, the P. CIRM-BIA 129 strain recently revealed promising immunomodulatory properties. Its consumption accordingly exerts healing effects in different animal models of colitis, suggesting potent role context inflammatory bowel diseases. This anti-inflammatory effect depends on surface layer proteins (SLPs). SLPs may...
Background Corynebacterium pseudotuberculosis is a zoonotic Gram-positive bacterial pathogen known to cause different diseases in many mammals, including lymph node abscesses camels. Strains from biovars equi and ovis of C. can infect Comparative genomics could help identify features related host adaptation, currently strain Cp162 biovar the only one camel with sequenced genome. Methods In this work, we compared quality three genome assemblies that used data DNA sequencing platforms SOLiD v3...
Streptococcus agalactiae, also referred to as Group B Streptococcus, is a frequent resident of the rectovaginal tract in humans, and major cause neonatal infection. The pathogen can infect adults with underlying disease, particularly elderly immunocompromised ones. In addition, S. agalactiae known fish pathogen, which compromises food safety represents zoonotic hazard. This study provides valuable structural, functional evolutionary genomic information human serotype Ia (ST-103) GBS85147...