A5044429968- Genetic Mapping and Diversity in Plants and Animals
- Animal Genetics and Reproduction
- Genetic and phenotypic traits in livestock
- Molecular Biology Techniques and Applications
- Virus-based gene therapy research
- Prion Diseases and Protein Misfolding
- Genomics and Phylogenetic Studies
- CRISPR and Genetic Engineering
- Probiotics and Fermented Foods
- Bacteriophages and microbial interactions
- Cancer-related molecular mechanisms research
- RNA and protein synthesis mechanisms
- Gut microbiota and health
- RNA Research and Splicing
- Trace Elements in Health
- Veterinary Oncology Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- RNA regulation and disease
- melanin and skin pigmentation
- Viral Infectious Diseases and Gene Expression in Insects
- Glycosylation and Glycoproteins Research
- Cancer-related gene regulation
- Chromosomal and Genetic Variations
- Neurological diseases and metabolism
- Wheat and Barley Genetics and Pathology
University of Göttingen
2016-2025
University of Bern
2009
University of Veterinary Medicine Hannover, Foundation
2009
University of Zurich
2009
Canadian Food Inspection Agency
2008
University of Calgary
2008
Universitätsmedizin Göttingen
1996-2005
University of Hohenheim
2005
Deutsche Forschungsgemeinschaft
2005
University of Southern Denmark
2004
Species fraud and product mislabelling in processed food, albeit not being a direct health issue, often results consumer distrust. Therefore methods for quantification of undeclared species are needed. Targeting mitochondrial DNA, e.g. CYTB gene, is unsuitable, due to fivefold inter-tissue variation mtDNA content per cell resulting either an under- (-70%) or overestimation (+160%) DNA contents. Here, we describe reliable two-step droplet digital PCR (ddPCR) assay targeting the nuclear F2...
Heat shock proteins act as molecular chaperones that have preferentially been transcribed in response to severe perturbations of the cellular homeostasis such heat stress. Here traits respiration rate (RR), rectal temperature (RT), pack cell volume (PCV) and individual tolerance coefficient (HTC) were recorded physiological responses on stress (environmental temperatures) Bos taurus (crossbred Holstein Friesian; HF) B. indicus (Thai native cattle: White Lamphun; WL Mountain cattle; MT)...
Background With the availability of massive SNP data for several economically important cattle breeds, haplotype tests have been performed to identify unknown recessive disorders. A number so-called lethal haplotypes, uncovered in Holstein Friesian and, at least seven these, causative mutations identified candidate genes. However, haplotypes still remain elusive. Here we report molecular genetic causes 5 (HH5) and cholesterol deficiency (CDH). targeted enrichment known genomic regions,...
In the present study, effects of dietary heat-killed Lactobacillus plantarum L-137 (HK L-137) on productive performance, intestinal morphology, and cytokine gene expression suckling-to-fattening pigs were investigated. A total 100 suckling [(Large White × Landrace) Duroc; 4.5 ± 0.54 kg initial body weight (BW)] used assigned to each four treatments as follows: (1) a control diet with antibiotics growth promoter (AGP) from phase grower no supplement in finisher phases; (2) without (NAGP); (3)...
Abstract Background Simple and precise methods for sex determination in animals are a pre-requisite number of applications animal production forensics. However, some the existing depend only on detection Y-chromosome specific sequences. Therefore, abscence signal does not necessarily mean that sample is female origin, because experimental errors can also lead to negative results. Thus, Y- X-chromosome sequences advantageous. Results A novel method identification mammals (sheep, Ovis aries...
Mammary tumors are the most frequent cancers in female dogs exhibiting a variety of histopathological differences. There is lack knowledge about genomes these common dog tumors. Five three different histological subtypes were evaluated. Massive parallel sequencing (MPS) was performed comparison to respective somatic genome each animal. Copy number and structural aberrations validated using droplet digital PCR (ddPCR). Using mate-pair chromosomal aneuploidies found two tumors, smaller...
White Galloway cattle exhibit three different white coat colour phenotypes, that is, well marked, strongly marked and mismarked. However, mating of individuals with the preferred or phenotype also results in offspring undesired mismarked and/or even fully black colour. To elucidate genetic background variations cattle, we analysed four relevant genes: mast/stem cell growth factor receptor (KIT), KIT ligand (KITLG), melanocortin 1 (MC1R) tyrosinase (TYR). Here, show Park are caused by a gene...
Abstract In this study, I report an unexpected case of a Holstein calf that developed horns even though the sire was homozygous and dam heterozygous for polledness. After verifying confirming correct parentage, parents offspring were genotyped with Illumina EuroG_MD BeadChip SNPs in polled region on chromosome 1 evaluated. addition, father sequenced next generation sequencing to identify possible, previously unknown variants. The deletion two base pairs within causative 80‐kb duplication...
Escherichia coli (E. coli) carrying the transmissible locus of stress tolerance (tLST) are able to overcome numerous environmental challenges. In our in-silico study, we aimed characterize tLST in terms its variants 793 genomes E. from Brazil originating food, and clinical (animal human) sources, perform a temporal analysis order identify historical moment emergence. We also analyzed presence two Yersinia high pathogenicity island (HPI) genomes, describing other genes accessory for...
The genus Pseudomonas includes metabolically versatile microorganisms occupying diverse niches, from environmental habitats to plant pathogens, and has clinically significant strains. For this reason, spp. might act as a reservoir of antimicrobial resistance genes, which have been detected even in isolated environments. aim study was report the susceptibility profile 25 fluorescens isolates soil samples collected on King George Island (Antarctic Peninsula), select non-clonal with unusual...
Salmonella Gallinarum is a bacterium that causes significant economic losses in poultry farming and usually infects adult birds. This study aims to characterize the unusual histological findings genetic profile of (SG) strain isolated from natural outbreak affected 1,500 broiler chicks their first week life. To confirm diagnosis, necropsy, histopathology, immunohistochemistry were performed on 19 chicks, with bacterial isolation two them, followed by confirmation through PCR, sequencing,...
Introduction Next-generation sequencing (NGS) has played a pivotal role in the advancement of taxonomics, allowing for accurate identification, differentiation, and reclassification several bacteria species. Bacillus velezensis is Gram-positive, facultatively aerobic, spore-forming bacterium known its antimicrobial antifungal properties. Strains this species are highly relevant agriculture, biotechnology, food industry, biomedicine. Methods In study, we characterized genomes nine strains...
A joint analysis of five paternal half-sib Holstein families that were part two different granddaughter designs (ADR- or Inra-design) was carried out for milk production traits and somatic cell score in order to conduct a QTL confirmation study increase the experimental power. Data exchanged coded standardised form. The combined data set (JOINT-design) consisted on average 231 sires per grandsire. Genetic maps calculated 133 markers distributed over nine chromosomes. analyses performed...