A5041163306- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Genetics and Plant Breeding
- Milk Quality and Mastitis in Dairy Cows
- Animal Nutrition and Physiology
- Animal Behavior and Welfare Studies
- Click Chemistry and Applications
- Wheat and Barley Genetics and Pathology
- Chemical Synthesis and Analysis
- Effects of Environmental Stressors on Livestock
- Enzyme Catalysis and Immobilization
- Cancer-related molecular mechanisms research
- Animal Genetics and Reproduction
- Reproductive Physiology in Livestock
- Monoclonal and Polyclonal Antibodies Research
- Biochemical and Structural Characterization
- Ubiquitin and proteasome pathways
- Livestock Management and Performance Improvement
- Veterinary Equine Medical Research
- Protein Kinase Regulation and GTPase Signaling
- Cellular transport and secretion
- Biotin and Related Studies
- Lipid Membrane Structure and Behavior
- Endoplasmic Reticulum Stress and Disease
- biodegradable polymer synthesis and properties
Roche (Switzerland)
2007-2023
Deutsches Herzzentrum München
2023
Max Planck Institute of Molecular Physiology
2001-2007
Harvard University
2006
Institute of Biochemistry
2006
Max Planck Society
2001-2006
TU Dortmund University
2005
University of Guelph
1995-1996
Size of the reference population and reliability phenotypes are crucial factors influencing genomic predictions. It is therefore useful to combine closely related populations. Increased accuracies predictions depend on number individuals added population, their phenotypes, relatedness populations that combined. This paper assesses increase in achieved when combining four Holstein 4000 bulls each, from European breeding organizations, i.e. UNCEIA (France), VikingGenetics (Denmark, Sweden,...
The purpose of this work was to study the impact both size genomic reference populations and inclusion a residual polygenic effect on dairy cattle genetic evaluations enhanced with information. Direct values were estimated for German Holstein BLUP model including effect. A total 17,429 genotyped bulls evaluated using phenotypes 44 traits. Interbull validation test implemented investigate how impacted breeding values. As number increased, variance estimates single nucleotide polymorphism...
Compared with the currently widely used multi-step genomic models for evaluation, single-step can provide more accurate evaluation by jointly analyzing phenotypes and genotypes of all animals properly correct effect preselection on genetic evaluations. The objectives this study were to introduce a model, allowing direct estimation single nucleotide polymorphism (SNP) effects, develop efficient computing algorithms solving equations SNP model. We proposed an alternative current model based...
A joint analysis of five paternal half-sib Holstein families that were part two different granddaughter designs (ADR- or Inra-design) was carried out for milk production traits and somatic cell score in order to conduct a QTL confirmation study increase the experimental power. Data exchanged coded standardised form. The combined data set (JOINT-design) consisted on average 231 sires per grandsire. Genetic maps calculated 133 markers distributed over nine chromosomes. analyses performed...
Posttranslational modification of proteins with farnesyl and geranylgeranyl isoprenoids is a widespread phenomenon in eukaryotic organisms. Isoprenylation conferred by three protein prenyltransferases: transferase (FTase), type-I (GGTase-I), Rab geranylgeranyltransferase (RabGGTase). Inhibitors these enzymes have emerged as promising therapeutic compounds for treatment cancer, viral parasite originated diseases, well osteoporosis. However, no generic nonradioactive prenyltransferase assay...
The site-selective modification of proteins with a functional group is an important biochemical technique, but covalent attachment desired to chosen site complicated by the reactivity other amino acid side chains, often resulting in undesired reactions. One potential solution this problem involves exploiting activity protein-modifying enzymes that recognize defined protein sequence. Protein farnesyltransferase (FTase) covalently attaches isoprenoid moiety cysteine unit context short...
A highly efficient asymmetric synthesis of the Akt kinase inhibitor ipatasertib (1) is reported. The bicyclic pyrimidine 2 starting material was prepared via a nitrilase biocatalytic resolution, halogen-metal exchange/anionic cyclization, and diastereoselective ketone reduction as key steps. route also features halide activated, Ru-catalyzed hydrogenation vinylogous carbamic acid to produce α-aryl-β-amino 3 in high yield enantioselectivity. API assembled convergent manner through late-stage...
Abstract The experimental power of a granddaughter design to detect quantitative trait loci (QTL) in dairy cattle is often limited by the availability progeny-tested sires, ignoring already identified QTL statistical analysis, and application stringent experimentwise significance levels. This study describes an experiment that addressed these points. A large was set up included sires from two countries (Germany France), resulting almost 2000 sires. animals were genotyped for markers on nine...
An important issue in quantitative trait loci (QTL) detection is the use of phenotypic measurement as a dependent variable. Daughter yield deviations (DYDs) unit choice are not available for all traits interest. The de‐regressed proofs (DRPFs) estimated breeding values (EBVs) an alternative to using daughter deviations. objective this study was examine possible differences between DYDs and DRPFs within QTL detection. pedigree used part granddaughter design German effort. Consisting marker...