Martin H. Groschup
A5078928217- Viral Infections and Vectors
- Prion Diseases and Protein Misfolding
- Mosquito-borne diseases and control
- Neurological diseases and metabolism
- Vector-Borne Animal Diseases
- Trace Elements in Health
- Viral Infections and Outbreaks Research
- Animal Disease Management and Epidemiology
- Fire effects on ecosystems
- Viral gastroenteritis research and epidemiology
- Hepatitis Viruses Studies and Epidemiology
- Malaria Research and Control
- Vector-borne infectious diseases
- Virology and Viral Diseases
- Zoonotic diseases and public health
- Animal Virus Infections Studies
- Metallurgy and Material Science
- SARS-CoV-2 and COVID-19 Research
- Animal Genetics and Reproduction
- Hepatitis B Virus Studies
- Veterinary medicine and infectious diseases
- RNA regulation and disease
- Insect symbiosis and bacterial influences
- Liver Disease and Transplantation
- Microbial infections and disease research
Friedrich-Loeffler-Institut
2016-2025
German Center for Infection Research
2018-2024
Institut Pasteur
2024
Institut Pasteur du Laos
2024
Institut de Recherche Agronomique de Guinée
2024
University of Castilla-La Mancha
2024
Consejo Superior de Investigaciones Científicas
2024
University of Córdoba
2024
Novel (Germany)
2004-2022
Philipps University of Marburg
2020
In neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's (PD) and prion diseases, deposits of aggregated disease-specific proteins are found. Oligomeric aggregates presumed to be the key neurotoxic agent. Here we describe novel oligomer modulator anle138b [3-(1,3-benzodioxol-5-yl)-5-(3-bromophenyl)-1H-pyrazole], an aggregation inhibitor developed based on a systematic high-throughput screening campaign combined with medicinal chemistry optimization. vitro, blocked...
Hepatitis E virus (HEV) is the causative agent of acute hepatitis in humans developing countries, but autochthonous cases zoonotic genotype 3 (HEV-3) infection also occur industrialized countries. In contrast to swine, rats, and rabbits, natural HEV infections mice have not yet been demonstrated. The pig represents a well-established large animal model for HEV-3 infection, suitable small mimicking currently missing. Therefore, we experimentally inoculated C57BL/6 (wild-type, IFNAR−/−,...
Raccoon dogs might have been intermediate hosts for severe acute respiratory syndrome-associated coronavirus in 2002-2004. We demonstrated susceptibility of raccoon to syndrome 2 infection and transmission in-contact animals. Infected animals had no signs illness. Virus replication tissue lesions occurred the nasal conchae.
To elucidate the role played by prion protein in scrapie pathogenesis, we performed experiments with PrP27–30 isolated from scrapie‐infected hamster brains cell culture and studied vivo temporal spatial correlation between deposition of disease‐associated isoform (PrP Sc ), microglial activation neuronal death mice infected strains 79A, ME7 RML. The results presented here show that cellular expression PrP c presence microglia are necessary for neurotoxicity vitro. In , accumulation...
We have isolated RNA aptamers which are directed against the recombinant Syrian golden hamster prion protein rPrP23-231 (rPrPc) fused to glutathione S-transferase (GST). The did not recognize fusion partner GST or GST::rPrP90-231 (rPrP27-30), lacks 67 amino acids from PrP N terminus. aptamer-interacting region of PrPc was mapped N-terminal 23 52. Sequence analyses suggest that may fold into G-quartet-containing structural elements. Replacement G residues in quartet scaffold with uridine...
This study aimed to identify the causative agent of mass mortality in wild and captive birds southwest Germany gather insights into phylogenetic relationship spatial distribution pathogen. Since June 2011, 223 dead were collected tested for presence viral pathogens. Usutu virus (USUV) RNA was detected by real-time RT-PCR 86 representing 6 species. The isolated cell culture from heart 18 Blackbirds (Turdus merula). USUV-specific antigen demonstrated immunohistochemistry brain, heart, liver,...
Usutu virus (USUV) is a mosquito-borne flavivirus that emerged 2001 in Austria and caused deaths wild birds. In Germany, 70,378 female mosquitoes were captured 2009 2010 assayed for USUV. Virus was isolated cell culture from one pool of Culex pipiens trapped exclusively August Weinheim, Germany. Subsequent phylogenetic analysis demonstrated close relationship between the USUV strain Germany Austria, which detected dead blackbird 2004.
Transmissible spongiform encephalopathy strains can be differentiated by their behavior in bioassays and molecular analyses of the disease-associated prion protein (PrP) a posttranslationally transformed conformation (PrPSc). Until recently, isolates from cases bovine (BSE) appeared to very homogeneous. However, limited number atypical BSE have recently been identified upon proteinase K (PK) resistance-associated moiety PrPSc (PrPres), suggesting existence at least two additional PrPres...
Atypical neuropathological and molecular phenotypes of bovine spongiform encephalopathy (BSE) have recently been identified in different countries. One these phenotypes, named "amyloidotic" (BASE), differs from classical BSE for the occurrence a distinct type disease-associated prion protein (PrP), termed PrPSc, presence PrP amyloid plaques. Here, we show that agents responsible BASE possess biological properties upon transmission to transgenic mice expressing inbred lines nontransgenic...
In the summer of 2016, Belgium, France, Germany and Netherlands reported widespread Usutu virus (USUV) activity based on live dead bird surveillance. The causative USUV strains represented four lineages, which two putative novel lineages were most likely recently introduced into spread to other western European countries. spatial extent outbreak area corresponded with R 0 values > 1. occurrence outbreak, largest epizootic registered so far in Europe, allowed us gain insight how a...
The summer of 2018 in Germany was the second hottest and driest on record. These generally extremely favorable climatic conditions most likely triggered further expansion efficient propagation zoonotic arthropod-borne West Nile virus many Southern/Southeastern even Central European countries. WNV infections were detected for first time resident wild aviary birds, such as common blackbirds, northern goshawks great grey owls Eastern Southeastern Germany. causative strain belonged to central...
Usutu virus (USUV), one of the most neglected Old World encephalitic flaviviruses, causes epizootics among wild and captive birds sporadic infection in humans. The dynamics USUV spread evolution its natural hosts are unknown. Here, we present phylogeny evolutionary history all available strains, including 77 newly sequenced complete genomes from a variety host species at temporal spatial scaled resolution. results showed that can be classified into six distinct lineages recent common...
One year after the first autochthonous transmission of West Nile virus (WNV) to birds and horses in Germany, an epizootic emergence WNV was again observed 2019. The number infected considerably higher compared 2018 (12 birds, two horses), resulting observation epidemy Germany: 76 cases 36 five confirmed mosquito-borne, human cases. We demonstrated that Germany experienced several introduction events strains a distinct group (Eastern German clade), which introduced as single event, dominated...
The emergence of variant Creutzfeldt Jakob Disease (vCJD) is considered a likely consequence human dietary exposure to Bovine Spongiform Encephalopathy (BSE) agent. More recently, secondary vCJD cases were identified in patients transfused with blood products prepared from apparently healthy donors who later went on develop the disease. As there no validated assay for detection vCJD/BSE infected individuals prevalence disease population remains uncertain. In that context, risk borne...