A5040171967- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Vector-Borne Animal Diseases
- Viral Infections and Outbreaks Research
- Fire effects on ecosystems
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Viral Infectious Diseases and Gene Expression in Insects
- Insect Resistance and Genetics
- Vector-borne infectious diseases
- Animal Virus Infections Studies
- Entomopathogenic Microorganisms in Pest Control
- vaccines and immunoinformatics approaches
- Virus-based gene therapy research
- Plant Virus Research Studies
- Viral gastroenteritis research and epidemiology
- interferon and immune responses
- COVID-19 epidemiological studies
- T-cell and B-cell Immunology
- Long-Term Effects of COVID-19
- Animal Disease Management and Epidemiology
- Influenza Virus Research Studies
- Bacteriophages and microbial interactions
- Parvovirus B19 Infection Studies
- Salmonella and Campylobacter epidemiology
Wuhan Institute of Virology
2016-2025
Chinese Academy of Sciences
2016-2025
China Automotive Technology and Research Center
2022-2024
University of Chinese Academy of Sciences
2024
Shaoxing City Women and Children Hospital
2023
Shaoxing University
2023
National Institutes for Food and Drug Control
2015-2023
Xinjiang University
2021
Xinjiang Uygur Autonomous Region Disease Prevention and Control Center
2021
Duke-NUS Medical School
2021
Abstract Long-term antibody responses and neutralizing activities in response to SARS-CoV-2 infection are not yet clear. Here we quantify immunoglobulin M (IgM) G (IgG) antibodies recognizing the receptor-binding domain (RBD) of spike (S) or nucleocapsid (N) protein, during a period 6 months from COVID-19 disease onset 349 symptomatic patients who were among first be infected world-wide. The positivity rate magnitude IgM-S IgG-N increase rapidly. High levels IgM-S/N IgG-S/N at 2-3 weeks...
Tick-borne viral diseases have attracted much attention in recent years because of their increasing incidence and threat to human health. Severe fever with thrombocytopenia syndrome phlebovirus (SFTSV) Heartland virus (HRTV) were recently identified as tick-borne phleboviruses (TBPVs) Asia the United States, respectively, are associated severe similar clinical manifestations. In this study, we report first identification isolation a novel TBPV named Guertu (GTV) from Dermacentor nuttalli...
For antiviral signaling mediated by retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs), the recruitment of cytosolic RLRs and downstream molecules (such as TBK1 IKKε) to mitochondrial platform is a central event that facilitates establishment host state. Here, we present an example viral targeting for immune evasion through spatial isolation TBK1/IKKε from platform, which was employed severe fever with thrombocytopenia syndrome virus (SFTSV), deadly bunyavirus emerging recently. We...
Abstract We describe the seroprevalence of severe fever with thrombocytopenia syndrome virus (SFTSV) and association antibody occurrence location, sex, age among human population in Pakistan. Our results indicate substantial activity SFTSV SFTSV-related viruses this country.
Abstract COVID-19 pandemic caused by SARS-CoV-2 constitutes a global public health crisis with enormous economic consequences. Monoclonal antibodies against can provide an important treatment option to fight COVID-19, especially for the most vulnerable populations. In this work, potent binding Spike protein were identified from convalescent patients. Among them, P4A1 interacts directly and covers majority of Receptor Binding Motif Receptor-Binding Domain, shown high-resolution complex...
Major advances have been made in understanding the dynamics of humoral immunity briefly after acute coronavirus disease 2019 (COVID-19). However, knowledge concerning long-term kinetics antibody responses convalescent patients is limited. During a one-year period post symptom onset, we longitudinally collected 162 samples from 76 and quantified IgM IgG antibodies recognizing nucleocapsid (N) protein or receptor binding domain (RBD) spike (S). After one year, approximately 90% recovered still...
Abstract Long-term antibody responses and neutralizing activities following SARS-CoV-2 infections have not yet been elucidated. We quantified immunoglobulin M (IgM) G (IgG) antibodies recognizing the receptor-binding domain (RBD) of spike (S) or nucleocapsid (N) protein, during a period six months COVID-19 disease onset in 349 symptomatic patients, which were among first world-wide being infected. The positivity rate magnitude IgM-S IgG-N increased rapidly. High levels IgM-S/N IgG-S/N at 2-3...
We detected Crimean-Congo hemorrhagic fever virus infections in 4 provinces of Pakistan during 2017-2018. Overall, seroprevalence was 2.7% humans and 36.2% domestic livestock. Antibody prevalence highest rural areas, where increased contact with animals is likely.
The ongoing Coronavirus Disease 2019 (COVID-19) pandemic caused by Severe Acute Respiratory Syndrome 2 (SARS-CoV-2) threatens global public health and economy unprecedentedly, requiring accelerating development of prophylactic therapeutic interventions. Molecular understanding neutralizing antibodies (NAbs) would greatly help advance the monoclonal antibody (mAb) therapy, as well design next generation recombinant vaccines. Here, we applied H2L2 transgenic mice encoding human immunoglobulin...
Infectious diseases caused by arboviruses are a public health concern in Pakistan. However, the studies on data prevalence and threats posed limited. This study investigated seroprevalence of healthy population Pakistan, including severe fever with thrombocytopenia syndrome virus (SFTSV), Crimean-Congo haemorrhagic (CCHFV), Tamdy (TAMV), Karshi (KSIV) based newly established luciferase immunoprecipitation system (LIPS) assays, Zika (ZIKV) enzyme-linked immunosorbent assays (ELISA)....
Crimean-Congo hemorrhagic fever is a tick-borne zoonotic disease that may be severe and present in many African countries. We aimed to understand the seroprevalence risk for virus Tanzania by testing archived serum samples from patients enrolled prospective cohort study.
Abstract Encephalomyocarditis virus (EMCV), a potential zoonotic pathogen, poses significant socioeconomic and public health challenges across various host species. Although EMCV rarely triggers severe clinical symptoms in humans, its widespread prevalence unique biological characteristics underscore the need for continuous surveillance development of effective therapeutics prophylactics. In this study, we evaluated neutralizing effects monoclonal antibody derived from spleens mice immunized...
The majority of double-stranded DNA (dsDNA) viruses infecting eukaryotic organisms use host- or virus-expressed histones protamine-like proteins to condense their genomes. In contrast, members the Baculoviridae family a protein named P6.9. dephosphorylated form P6.9 binds in non-sequence-specific manner. By using p6.9-null mutant Autographa californica multiple nucleopolyhedrovirus (AcMNPV), we demonstrate that is not required for viral replication but essential production infectious virus....
Hantaviruses, which belong to the genus Hantavirus in family Bunyaviridae, infect mammals, including humans, causing either hemorrhagic fever with renal syndrome (HFRS) or hantavirus cardiopulmonary (HCPS) humans high mortality. encodes a nucleocapsid protein (NP) encapsidate genome and form ribonucleoprotein complex (RNP) together viral polymerase. Here, we report crystal structure of core domains NP (NPcore) encoded by Sin Nombre virus (SNV) Andes (ANDV), are two representative members...
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a novel phlebovirus that was identified to be the etiological pathogen of emerging infectious disease, severe (SFTS). SFTSV could transmitted through tick bite. Transmission among humans has also been reported mainly direct blood contact. In July 2014, cluster six suspected SFTS cases occurred in Shandong Province, China. this cluster, both symptomatic and asymptomatic persons were included. By analyzing clinical data results...