A5023009425- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis Viruses Studies and Epidemiology
- Immunotherapy and Immune Responses
- Liver Disease and Transplantation
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- COVID-19 Clinical Research Studies
- Animal Virus Infections Studies
- SARS-CoV-2 and COVID-19 Research
- RNA Interference and Gene Delivery
- Traditional Chinese Medicine Studies
- Viral gastroenteritis research and epidemiology
- Long-Term Effects of COVID-19
- Respiratory viral infections research
- Viral Infections and Outbreaks Research
- Cytomegalovirus and herpesvirus research
- COVID-19 epidemiological studies
- Vaccine Coverage and Hesitancy
- interferon and immune responses
- Healthcare and Venom Research
- Asthma and respiratory diseases
- Urinary Bladder and Prostate Research
- Acute Kidney Injury Research
Boston University
2025
Quest University Canada
2025
Shandong University of Traditional Chinese Medicine
2024
Kunming Children's Hospital
2024
Union Hospital
2014-2023
Huazhong University of Science and Technology
2014-2023
Union Hospital
2015-2021
Second Hospital of Anhui Medical University
2021
Anhui Medical University
2021
Second Military Medical University
2021
The dynamic changes of lymphocyte subsets and cytokines profiles patients with novel coronavirus disease (COVID-19) their correlation the severity remain unclear.
Abstract We have previously shown that Toll-like receptor (TLR)-activated murine nonparenchymal liver cells [(NPC); Kupffer (KC), sinusoidal endothelial (LSEC)] can suppress hepatitis B virus (HBV) replication. Therefore, the aim of this study was to investigate whether HBV has ability counteract TLR-mediated control its Freshly purified hepatocytes and NPCs obtained from C57BL6 mice were stimulated by TLR 1-9 ligands in presence or absence surface antigen (HBsAg), e (HBeAg), virions,...
Abstract Long-term antibody responses and neutralizing activities in response to SARS-CoV-2 infection are not yet clear. Here we quantify immunoglobulin M (IgM) G (IgG) antibodies recognizing the receptor-binding domain (RBD) of spike (S) or nucleocapsid (N) protein, during a period 6 months from COVID-19 disease onset 349 symptomatic patients who were among first be infected world-wide. The positivity rate magnitude IgM-S IgG-N increase rapidly. High levels IgM-S/N IgG-S/N at 2-3 weeks...
Hepatitis B virus (HBV) infection is one of the most frequent causes chronic liver disease worldwide. Because recent studies have suggested that Toll-like receptor (TLR)-based therapies may be a promising approach in treatment HBV infection, we studied role local innate immune system as possible mediator this effect. Murine nonparenchymal cells, including Kupffer cells (KCs) and sinusoidal endothelial (LSECs), were isolated from C57/BL6 wild-type or MyD88−/− mice stimulated by agonists TLR1...
Little is known of how the Toll-like receptor (TLR) system can modulate function non-parenchymal liver cells (NPC) as a major component innate and adaptive immune liver. To investigate diversification TLR signalling pathways in NPC, we isolated Kupffer (KC) sinusoidal endothelial (LSEC) from wild-type C57BL/6 mice examined their responses to TLR1 TLR9 agonists. The data show that KC respond all ligands by producing tumour necrosis factor-alpha (TNF-alpha) or interleukin-6 (IL-6), TLR3 TLR4...
The mechanism of exosomes derived from activated hepatic stellate cells (HSCs) involved in liver fibrosis is poorly understood. We previously reported that hypoxia-inducible factor 1 (Hif-1) regulated HSC activation, and, therefore, we investigated current work whether Hif-1 regulates exosome secretion and the metabolic switch HSCs, thus affecting metabolism nonparenchymal cells. In this study, characteristics HSCs were assessed via electron microscopy, Western blot analysis,...
Abstract Background The dynamic changes of lymphocyte subsets and cytokines profiles patients with novel coronavirus disease (COVID-19) their correlation the severity remain unclear. Methods Peripheral blood samples were longitudinally collected from 40 confirmed COVID-19 examined for by flow cytometry cytokine specific immunoassays. Results Of enrolled, 13 severe cases showed significant sustained decreases in counts but increases neutrophil than 27 mild cases. Further analysis demonstrated...
The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome 2 (SARS-CoV-2) affected over 120 million people and killed 2.7 individuals March 2021. While intermediate interactions between SARS-CoV-2 immune system have been studied extensively, long-term impacts on cellular remain to be analyzed. Here, we comprehensively characterized immunological changes in peripheral blood mononuclear cells 49 COVID-19-convalescent (CI) comparison 27 matched...
We have previously shown that poly(I:C) activates murine hepatic cells to produce interferon (IFN) and suppresses hepatitis B virus (HBV) replication in vitro. Therefore, we addressed whether is able induce the clearance of HBV vivo. The chronic mouse model was established by hydrodynamic injection (HI) pAAV-HBV1.2 into tail veins wild-type IFN-α/βR-, IFN-γ-, CXCR3-deficient C57BL/6 mice. Fourteen days post-HI pAAV-HBV1.2, mice were administered intraperitoneal injection, intramuscular or...
Abstract Long-term antibody responses and neutralizing activities following SARS-CoV-2 infections have not yet been elucidated. We quantified immunoglobulin M (IgM) G (IgG) antibodies recognizing the receptor-binding domain (RBD) of spike (S) or nucleocapsid (N) protein, during a period six months COVID-19 disease onset in 349 symptomatic patients, which were among first world-wide being infected. The positivity rate magnitude IgM-S IgG-N increased rapidly. High levels IgM-S/N IgG-S/N at 2-3...
We have previously shown that Toll-like receptor (TLR) agonists contribute to the control of viral infection by augmenting virus-specific CD8(+) T-cell responses. It is also well established signaling TLRs results in production pro-inflammatory cytokines such as interleukin 6 (IL-6). However, how these influence response during TLR agonist stimulation remained largely unknown. Here, we investigated role TLR-induced IL-6 shaping responses Friend retrovirus (FV) mouse model. show induced...
Flood is common in China and causes extensive loss of property human lives. Elderly a vulnerable population prone to the detrimental impacts floods. This survey aims investigate health status HRQoL elderly Bazhong city after major flood 2011. A total 1183 (aged > 60) were surveyed through random sampling from eight villages city. Two-week healthcare-seeking rate chronic diseases prevalence recorded anonymously. Health-related quality life (HRQoL) was measured by Medical Outcomes Study Short...
Policy Points Cell and gene therapies (CGTs) offer treatment for rare oftentimes deadly disease, but their prices are high, payers may seek to limit spending. Total annual costs of covering all existing expected CGTs the entire US population 2023-2035 amount less than $20 per person concentrate in commercial state Medicaid plans. Reinsurance fees add costs. Policies that improve coverage affordability needed assure patient access CGTs. diseases. Because high price uncertain clinical...
Recently, hepatitis E virus has been recognized as a new transfusion-associated risk; however, its efficiency of transmission through blood products requires further investigation. Asymptomatic viremia short duration observed in donors from several European countries to the rate <1:10,000 and HEV recipients documented Japan Europe. Although RNA was detected large plasma fractionation pools used for manufacturing derived products, not demonstrated so far. In this study, we investigated...
Summary The hepatitis C virus ( HCV ) establishes persistent infections despite strong activation of the innate immune system through TLR 3 and other sensors. Therefore, we analysed regulatory mechanisms 3‐induced responses in nonparenchymal liver cells NPC s). Effects Interleukin‐10 IL ‐10), transforming growth factor beta TGF ‐β) immunoregulatory mi R ‐155 on poly I : ‐activated murine 57 BL /6) K upffer KC sinusoidal endothelial LSEC were assessed vitro . s assayed for inflammatory...
This study was conducted to determine the association between sexually transmitted infection (STI) and prevalence of depression among general Canadian population.The analysis based on data from Community Health Survey in 2003 included 21,560 participants aged 15-49 years. A logistic regression model used examine STI history after taking confounding factors (gender, age, marital status, household size, income, education, immigrant alcohol use, smoking status number chronic diseases) effect...