A5101661823- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Hepatitis C virus research
- Parasites and Host Interactions
- Viral Infections and Vectors
- Cancer-related molecular mechanisms research
- SARS-CoV-2 and COVID-19 Research
- RNA modifications and cancer
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Vector-Borne Animal Diseases
- Wnt/β-catenin signaling in development and cancer
- Ultrasound and Hyperthermia Applications
- Mosquito-borne diseases and control
- HIV Research and Treatment
- Viral Infections and Outbreaks Research
- Fire effects on ecosystems
- Viral gastroenteritis research and epidemiology
- Peroxisome Proliferator-Activated Receptors
- HIV/AIDS drug development and treatment
- Cancer-related gene regulation
- Cell death mechanisms and regulation
- Cytokine Signaling Pathways and Interactions
- Systemic Lupus Erythematosus Research
First Affiliated Hospital of Guangzhou Medical University
2025
State Key Laboratory of Respiratory Disease
2025
Guangzhou Medical University
2025
The First People's Hospital of Guangyuan
2023
Huazhong University of Science and Technology
2005-2021
Union Hospital
2005-2021
Kunming Medical University
2008-2019
Air Force Medical University
2015
Wuhan No.1 Hospital
2007-2013
302 Military Hospital of China
2012
The dynamic changes of lymphocyte subsets and cytokines profiles patients with novel coronavirus disease (COVID-19) their correlation the severity remain unclear.
Background. Hemorrhagic fever–like illness caused by a novel Bunyavirus, Huaiyangshan virus (HYSV, also known as Severe Fever with Thrombocytopenia [SFTSV] and Fever, Leukopenia Syndrome [FTLS]), has recently been described in China. Methods. Patients laboratory-confirmed HYSV infection who were admitted to Union Hospital or Zhongnan between April 2010 October included this study. Clinical routine laboratory data collected blood, throat swab, urine, feces obtained when possible. Viral RNA...
Background: The dynamic changes of lymphocyte subsets and cytokines profiles patients with novel coronavirus disease (COVID-19) their correlation the severity remain unclear. Method: Peripheral blood samples were longitudinally collected from 40 confirmed COVID-19 examined for by flow cytometry cytokine specific immunoassays. Findings: Of enrolled, 13 severe cases showed significant sustained decreases in counts but increases neutrophil than 27 mild cases. Further analysis demonstrated T...
ABSTRACT Surveys were carried out to better understand the tick vector ecology and genetic diversity of Huaiyangshan virus (HYSV) in both regions endemicity nonendemicity. Haemaphysalis longicornis ticks dominant endemicity, while Rhipicephalus microplus is more abundant HYSV RNA was found human species, with greater prevalence H. lesser R. . Phylogenetic analyses indicate that a novel species genus Phlebovirus
Chronic hepatitis B and its life-threatening sequelae are highly prevalent in China. There is a need for effective new therapies to suppress virus (HBV) replication ameliorate liver disease. In this study, we compared the efficacy of telbivudine, nucleoside analogue, with lamivudine Chinese patients. phase III, double-blind, multicenter trial conducted China, 332 patients compensated e antigen (HBeAg)–positive or HBeAg-negative chronic were randomly assigned treatment 600 mg telbivudine 100...
Abstract Background The dynamic changes of lymphocyte subsets and cytokines profiles patients with novel coronavirus disease (COVID-19) their correlation the severity remain unclear. Methods Peripheral blood samples were longitudinally collected from 40 confirmed COVID-19 examined for by flow cytometry cytokine specific immunoassays. Results Of enrolled, 13 severe cases showed significant sustained decreases in counts but increases neutrophil than 27 mild cases. Further analysis demonstrated...
Human bronchial epithelial cell-derived extracellular vesicles have demonstrated the ability to attenuate fibroblasts activation. However, specific key effector cell populations mediating this inhibitory effect remain unidentified. Airway basal stem cells (BSCs), which serve as progenitor for cells, play a critical role in fibrotic remodeling processes and possess significant therapeutic potential. This study aimed characterize BSC-derived (BSC-EVs) investigate their regulatory influence on...
Background Human leukocyte antigen DP (HLA-DP) locus has been reported to be associated with hepatitis B virus (HBV) infection in populations of Japan and Thailand. We aimed examine whether the association can replicated Han Chinese populations. Methodology/Principal Findings Two HLA-DP variants rs2395309 rs9277535 (the most strongly SNPs from each locus) were genotyped three independent cohorts consisting 2 805 cases 1 796 controls. By using logistic regression analysis, these two HLA-DPA1...
To evaluate the effect of rosiglitazone in a murine model liver fibrosis induced by Schistosoma japonicum infection.A total 50 mice were randomly and averagely divided into groups A, B, C, D E. The group A served as normal controls, while those other four infected with to induce fibrosis. Besides, E treated praziquantel, praziquantel plus rosiglitazone, respectively. NF-kappaB binding activity expression PPAR gamma-mRNA determined Western blot assay real-time quantitative PCR....
Host genetics play a vital role in determining clinical outcomes of hepatitis B virus (HBV) infection. To identify novel susceptibility loci to HBV progression, we carried out genome-wide association study with DNA pooling. This assessed the relationship between 8 highly-ranked SNPs selected from our pool and disease progression infection two independent case-control studies. The first population included 628 asymptomatic carriers (AsC) 1729 progressed recruited Hubei Province south China....
CONCLUSION:Both PAP-S and PAP encoded by a eukaryotic expression plasmid could effectively inhibit HBV replication antigen in vitro , the inhibitory effects were dose-dependent.
Epilepsy is a common chronic neurological disorder worldwide. MicroRNAs (miRNAs) play an important role in the pathogenesis of epilepsy. However, mechanism regulatory effect miR-10a on epilepsy unclear. In this study, we investigated expression PI3K/Akt/mTOR signaling pathway and inflammatory cytokines epileptic hippocampal neurons rats. The miRNA differential profile rat brain was analyzed using bioinformatic approaches. Neonatal Sprague-Dawley were prepared as neuron models vitro by...
It is currently thought that the transforming growth factor-β (TGF-β)/Smad signaling pathway acts as a central leading to liver fibrosis, and aberrant Wnt/β-catenin also plays vital role in development of fibrosis. There evidence histidine triad nucleotide-binding protein 1 (Hint1) was capable inhibiting these two pathways. However, little data regarding effects Hint1 on fibrosis exists. Thus, we sought investigate whether recombinant human (rhHint1) attenuating induced by carbon...
Tongue squamous cell carcinoma is the most common malignant tumor in oral and maxillofacial regions. Recent research has found that artemether can inhibit growth induce apoptosis of cancer cells, although mechanism not clear. The present study aimed to explore correlation between HSP 90/ Akt pathway artemether‐induced Cal27 cells. A counting kit‐8 flow cytometry were used detect proliferation respectively, mRNA expression was examined by quantitative RT ‐ PCR , protein detected western...