A5008572122- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- Prostate Cancer Treatment and Research
- PARP inhibition in cancer therapy
- Traditional Chinese Medicine Studies
- Advanced Breast Cancer Therapies
- Protein Degradation and Inhibitors
- Reading and Literacy Development
- Peptidase Inhibition and Analysis
- Endoplasmic Reticulum Stress and Disease
- Synthesis and biological activity
- Mitochondrial Function and Pathology
- Quinazolinone synthesis and applications
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Tumors and Oncological Cases
- Biofield Effects and Biophysics
- Neurobiology of Language and Bilingualism
- Phenothiazines and Benzothiazines Synthesis and Activities
- Cytokine Signaling Pathways and Interactions
- Health Systems, Economic Evaluations, Quality of Life
- Autophagy in Disease and Therapy
- Natural Compounds in Disease Treatment
- Sarcoma Diagnosis and Treatment
Yuxian People's Hospital
2024
Qingdao Eighth People's Hospital
2018-2023
Xian Central Hospital
2019-2023
Zhejiang Chinese Medical University
2021
Shenyang Pharmaceutical University
2019-2020
First Hospital of Xi'an
2019
Hangzhou Hospital of Traditional Chinese Medicine
2019
Novartis (Switzerland)
2011-2016
Creative Research Enterprises (United States)
2016
Institut Cochin
2016
Background and Aims The Roadmap concept is a therapeutic framework in chronic hepatitis B for the intensification of nucleoside analogue monotherapy based on early virologic response. efficacy safety this approach applied to telbivudine treatment has not been investigated. Methods A multinational, phase IV, single-arm open-label study (ClinicalTrials.gov ID NCT00651209) was undertaken HBeAg-positive, nucleoside-naive adult patients with B. Patients received (600 mg once-daily) 24 weeks,...
Oxymatrine has been shown to have a remarkable inhibitory activity hepatitis B virus (HBV) infection with e antigen (HBeAg) serum conversion rate of approximately 45%. In order explore the anti-HBV mechanism oxymatrine, effects oxymatrine on levels T helper (h)1 cytokines (interferon (IFN)-gamma and interleukin (IL)-2) Th2 (IL-4 IL-10), expression S gene in HBV transgenic mice were studied.Each mouse was either injected or saline intraperitoneally once day for 30 days. Serum IFN-gamma, IL-2,...
Aim This study aims to design a 100-h training programme for nursing innovation teams and evaluate the effect of this using Kirkpatrick's model. Background The innovative capability nurses is powerful driver development discipline, it currently at low medium level in China. Innovation competency has become research trend nurses' in-service education, but only changes behaviours before after have been evaluated. cascading, continuous assessment tools are rarely used. Methods...
The long-term goal of chronic hepatitis B (CHB) treatment is improvement liver disease and prevention cirrhosis. aim this study was to assess whether prolonged telbivudine improves inflammation fibrosis. primary objective evaluate the proportion patients with absence/minimal (Knodell necroinflammatory score ≤3) on biopsy at Year 5. Fifty-seven aged 16–70 years a clinical history CHB active viral replication (38 e antigen [HBeAg] positive 19 HBeAg negative) were followed for 6 years: 33...
Abstract Age‐related macular degeneration (AMD), one of the most common causes visual impairment, often occurrs in elderly developed countries. Oxidative stress, autophagy, and apoptosis retinal pigment epithelial (RPE) cells play roles pathogenesis AMD. In current study, protective effect celastrol against hydrogen peroxide (H 2 O )‐induced oxidative stress was investigated using a human RPE cell line (ARPE‐19). H inhibited ARPE‐19 cells' survival autophagy induced their apoptosis. Compared...
AIM:To achieve an evidence-based conclusion regarding the safety and efficacy of telbivudine during pregnancy. METHODS:A pooled analysis data from a literature search reported 1739 pregnancy outcomes (1673 live births) 1725 non-overlapping pregnant women treated with telbivudine.The prevalence birth defects (3.6/1000) was similar to that nonantiviral controls (3.0/1000) not increased as compared overall (14.5 60/1000).No target organ toxicity identified.The spontaneous abortion in (4.2/1000)...
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic caused by a tick-borne bunyavirus SFTSV case fatality up to 30%. The reactivation of Epstein-Barr virus (EBV) has been proven occur in individuals various immune suppression conditions.
Abstract Purpose Retinopathy of prematurity (ROP) is a disease that causes vision loss, impairment, and blindness, most frequently manifesting among preterm infants. ROPScore CHOP ROP (Children’s Hospital Philadelphia ROP) are similar scoring models to predict using risk factors such as postnatal weight gain, birth (BW), gestation age (GA). The purpose this study was compare the accuracy difference between for early prediction ROP. Methods A retrospective conducted from January 2009 December...
Numerous studies have focused on the understanding of rapid automatized naming (RAN), which can be applied to predict reading abilities and developmental dyslexia in children. Eye tracking technique, characterizing essential ocular activities, might feasibility reveal visual cognitive features RAN. However, traditional measures eye movements ignore many dynamical details about processing RAN, are usually associated with duration time spent some particular areas interest, fixation counts,...
To investigate the liver pathological characteristics and clearance rate of hepatitis B surface antigen (HBsAg) with antiviral treatment for 1 to 7 years old children heptitis e antigen(HBeAg)-negative chronic B.A total 49 cases HBeAg-negative were treated interferon (IFN) or IFN 6 months added lamivudine, followed up at least months.Retrospective analysis was performed on characteristics, efficacy antivirus its influencing factors HBsAg in from June 2006 December 2013 302 Hospital People's...
Objective: To investigate the HBsAg clearance rate after antiviral therapy in children with HBeAg-positive chronic hepatitis B (CHB) aged 1-7 years. Methods: A retrospective analysis was performed for 293 who were hospitalized 302 Hospital of PLA from June 2006 to December 2013, met inclusion criteria, received therapy, and followed up at least 6 months withdrawal therapy. The t-test or rank sum test applied according distribution continuous data, chi-square used comparison categorical data....
Most neurodegenerative diseases such as Alzheimer's disease are proteinopathies linked to the toxicity of amyloid oligomers. Treatments delay or cure these lacking. Using budding yeast, we report that natural lipid tripentadecanoin induces expression nitric oxide oxidoreductase Yhb1 prevent formation protein aggregates during aging and extends replicative lifespan. In mammals, orthologue, neuroglobin, protect neurons against toxicity. Tripentadecanoin also rescues photoreceptors in a mouse...
A 2-year roadmap study was conducted to evaluate the efficacy and safety of tenofovir intensification at Week 24 in patients with chronic hepatitis B (CHB) receiving telbivudine.A prospective multicenter treatment-naive e antigen (HBeAg)-positive CHB. All received telbivudine (600 mg/day) until 24. Thereafter, detectable virus (HBV) DNA (≥300 copies/mL) were administered (300 plus telbivudine, undetectable HBV continued monotherapy 104. The primary endpoint proportion (<300 Weeks 52 104.A...
Changes of body immunity and inflammatory response in human immunodeficiency virus (HIV)/hepatitis C (HCV) co-infected patients were investigated. Eighty HIV/HCV infected admitted to Qingdao No. 6 People's Hospital from August 2015 December 2017 selected divided into two groups according whether they complicated with HCV infection or not (n=40 per group). The changes the related humoral immune indexes, cellular indexes hepatic function, compared, correlations high-sensitivity C-reactive...
e21568 Background: In China, cancer patients may choose to practice FLG -- the most popular Qigong since 1992 after treatment failure, arousing great interest in medical society. Methods: We collected reports from Chinese between 2000 and 2015 via a web platform, including diagnosis, duration, Actual Survival (AS) till report date, symptom improvement, Quality of Life (QoL). All were reviewed by 2 physicians. Predicted (PS) was assessed using NIH SEER data if treating physician’s Clinical...