A5026956100- Parasites and Host Interactions
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Parasite Biology and Host Interactions
- Macrophage Migration Inhibitory Factor
- Liver physiology and pathology
- SARS-CoV-2 and COVID-19 Research
- Tea Polyphenols and Effects
- Helminth infection and control
- Immunodeficiency and Autoimmune Disorders
- Chronic Lymphocytic Leukemia Research
- Research on Leishmaniasis Studies
- Antioxidant Activity and Oxidative Stress
- RNA Research and Splicing
- Liver Disease Diagnosis and Treatment
- Tannin, Tannase and Anticancer Activities
- Immune responses and vaccinations
- Phytochemicals and Antioxidant Activities
- Child Nutrition and Water Access
- Digestive system and related health
- Social Media in Health Education
- IL-33, ST2, and ILC Pathways
- Free Radicals and Antioxidants
- Liver Disease and Transplantation
- Global Maternal and Child Health
Huazhong University of Science and Technology
2012-2024
Tangshan People's Hospital
2018
Shanghai Jiao Tong University
2016-2017
Rutgers, The State University of New Jersey
2003-2013
Institute of Botany
2012
Rutgers Cancer Institute of New Jersey
2012
Cancer Institute of Florida
2012
Cornell University
2010
University of Massachusetts Amherst
2010
Beijing Tongren Hospital
2010
(−)-Epigallocatechin-3-gallate (EGCG), the major polyphenol in green tea, has been shown to inhibit tumorigenesis and cancer cell growth animal models. Nevertheless, dose–response relationship of inhibitory activity vivo not systematically characterized. The present studies were conducted address these issues, as well involvement reactive oxygen species (ROS), action EGCG vitro . We characterized actions against human lung H1299 cells culture xenograft tumors. tumors was dose dependently...
The mechanism of exosomes derived from activated hepatic stellate cells (HSCs) involved in liver fibrosis is poorly understood. We previously reported that hypoxia-inducible factor 1 (Hif-1) regulated HSC activation, and, therefore, we investigated current work whether Hif-1 regulates exosome secretion and the metabolic switch HSCs, thus affecting metabolism nonparenchymal cells. In this study, characteristics HSCs were assessed via electron microscopy, Western blot analysis,...
ABSTRACTThe coronavirus disease 2019 (COVID-19) has caused enormous health risks and global economic disruption. This is by the severe acute respiratory syndrome 2 (SARS-CoV-2). The SARS-CoV-2 nucleocapsid protein a structural involved in viral replication assembly. There accumulating evidence indicating that multi-functional, playing key role pathogenesis of COVID-19 antiviral immunity against SARS-CoV-2. Here, we summarize its potential application prevention COVID-19, which based on...
The cancer preventive activity of vitamin E has been extensively discussed, but the activities specific forms tocopherols have not received sufficient attention. Herein, we compared δ-tocopherol (δ-T), γ-T, and α-T in a colon carcinogenesis model. Male F344 rats, seven weeks old, were given two weekly subcutaneous injections azoxymethane (AOM) each at dose 15 mg/kg body weight. Starting 1 week before AOM injection, animals maintained on modified AIN76A diet, or same diet containing 0.2% δ-T,...
Peroxisome proliferator-activated receptor γ (PPARγ) has been shown to be a therapeutic target for preeclampsia (PE). Angiopoietin-like protein 4 (ANGPTL4) is multifunctional secretory involved in regulating lipid metabolism and angiogenesis various tissues. However, the expression of PPARγ ANGPTL4 their interaction PE remain elusive. Here we showed that agonist rosiglitazone upregulated secretion dose-dependent manner HTR8/SVneo cells, human umbilical vein endothelial cells (HUVECs)...
BackgroundHepatic stellate cell (HSC) plays a key role in pathogenesis of liver fibrosis. During injury, hypoxia local micro-environment is inevitable. Hif-1α the transcriptional regulation factor that induces cell's adaptive responses to hypoxia. Recently, it was reported MAPK involved activity. AimsTo explore whether regulates HSC activation upon hypoxia, and affects Hif-1α-regulated signaling cascades, thus providing new targets for preventing MethodsHif-1α expression livers Schistosoma...
The increased activity of regulatory B cells (Breg) is known to be involved in immunosuppression during helminth infection, which characterized by inducing IL-10-producing Breg cells. However, the current knowledge cell subsets differentiation and IL-10-independent immunoregulatory mechanisms schistosomiasis insufficient.BALB/c mice were percutaneously infected with cercariae for investigating profile Schistosoma japonicum infection. isolated from spleen or peritoneal cavity analyzed...
Reducing or eliminating expression of a given gene is likely to require multiple methods ensure coverage all the genes in mammalian cell. We and others [Furth, P. A., Choe, W. T., Rex, J. H., Byrne, C., Baker, C. (1994) Mol. Cell. Biol. 14, 5278-5289] have previously shown that U1 small nuclear (sn) RNA, both natural with 5' end mutations, can specifically inhibit reporter cells. This inhibition occurs when snRNA base pairs near polyadenylation signal gene's pre-mRNA. pairing inhibits...
Inflammatory bowel diseases (IBDs) have been classified as modern refractory diseases. However, safe, well-tolerated, and effective treatments for IBDs are still lacking. Therefore, there is an urgent need to develop novel therapeutic targets with fewer undesirable adverse reactions. A growing body of research has shown that infection live helminths or exposure defined helminth-derived components can downregulate pathogenic inflammation due their immunoregulatory ability. Here we were...
SARS-CoV-2 caused the COVID-19 pandemic. may elevate risk of cognitive impairment and even cause dementia in infected individuals; it accelerate decline elderly patients with dementia, possibly Alzheimer's disease (AD) patients. However, mechanisms underlying interplay between AD are still unclear. To investigate associations progression infection, we conducted a series bioinformatics research into SARS-CoV-2-infected cells, patients, We identified common differentially expressed genes...
Background Hepatitis B and schistosomiasis are most prevalent in Africa Asia, co-infections of both frequent these areas. The immunomodulation reported to be induced by schistosome infections might restrict immune control hepatitis virus (HBV) leading more severe viral infection. Vaccination is the effective measure prevent HBV infection, but there evidence for a reduced response vaccine patients with chronic japonica. Methodology/Principal Findings In this paper, we demonstrate mouse model...
Epigallocatechin-3-gallate (EGCG), atorvastatin (ATST), and their combination have been previously shown to inhibit colon carcinogenesis in animal models. We further investigated inhibitory activities azoxymethane (AOM) dextran sulfate sodium (DSS)-treated Balb/cJ mice CD-1 2 slightly different The were maintained on the AIN93M diet, or a similar diet containing 0.03%, 0.1%, 0.3% EGCG; 60-ppm ATST; of 0.1% EGCG ATST. Unexpectedly, no significant activity was observed, some treatment groups...
Tocopherols are the major source of dietary vitamin E. In this study, growth inhibitory effects different forms tocopherols (T), tocopheryl phosphates (TP), and tocopherol quinones (TQ) on human colon cancer HCT116 HT29 cells were investigated. δ-T was more active than γ-T in inhibiting cell growth, decreasing colony formation, inducing apoptosis; however, α-T rather ineffective. Similarly, rate cellular uptake also followed ranking order > ≫ α-T. TP TQ generally had higher activities their...
Abstract IgG4-related disease (IgG4-RD) has complex clinical manifestations ranging from fibrosis and inflammation to deregulated metabolism. The molecular mechanisms underpinning these phenotypes are unclear. In this study, by using IgG4-RD patient peripheral blood mononuclear cells (PBMCs), cell lines Usp 25 knockout mice, we show that ubiquitin-specific protease (USP25) engages in multiple pathways regulate fibrotic inflammatory characteristic IgG4-RD. Reduced USP25 expression leads...
Liver fibrosis is the most serious pathology caused by Schistosoma japonicum infection, which arises when schistosome eggs are deposited in liver. Eosinophils, macrophages and hepatic stellate cells (HSCs) have been identified as major cellular contributors to development of granulomas fibrosis, but little known about effects hepatocytes on granuloma formation. Here, we found that levels Wnt signalling-related molecules, transforming growth factor β (TGF-β) connective tissue (CTGF) were...
Trichinellosis is one of most neglected foodborne zoonoses worldwide. During Trichinella spiralis infection, the intestinal immune response first line defense and plays a vital role in host’s resistance.