A5023611045- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Cardiac Valve Diseases and Treatments
- Genomics and Phylogenetic Studies
- Aortic Disease and Treatment Approaches
- Advanced biosensing and bioanalysis techniques
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Acupuncture Treatment Research Studies
- Quantum Chromodynamics and Particle Interactions
- Aortic aneurysm repair treatments
- Particle physics theoretical and experimental studies
- Glioma Diagnosis and Treatment
- Metal-Organic Frameworks: Synthesis and Applications
- High-Energy Particle Collisions Research
- Advanced Neuroimaging Techniques and Applications
- COVID-19 and healthcare impacts
- Shoulder Injury and Treatment
- Covalent Organic Framework Applications
- Cell Adhesion Molecules Research
- Receptor Mechanisms and Signaling
- Healthcare and Venom Research
- Ferroptosis and cancer prognosis
- Electrospun Nanofibers in Biomedical Applications
Guangdong Pharmaceutical University
2025
Wuhan Union Hospital
2025
Union Hospital
2014-2024
Huazhong University of Science and Technology
2014-2024
Jinyintan Hospital
2020-2024
Shandong University of Traditional Chinese Medicine
2023-2024
Union Hospital
2023-2024
Sichuan Academy of Agricultural Sciences
2021-2024
Linyi People's Hospital
2016-2024
Nanjing Tech University
2023-2024
No therapeutics have yet been proven effective for the treatment of severe illness caused by SARS-CoV-2.We conducted a randomized, controlled, open-label trial involving hospitalized adult patients with confirmed SARS-CoV-2 infection, which causes respiratory Covid-19, and an oxygen saturation (Sao2) 94% or less while they were breathing ambient air ratio partial pressure (Pao2) to fraction inspired (Fio2) than 300 mm Hg. Patients randomly assigned in 1:1 receive either lopinavir-ritonavir...
Abstract Long-term antibody responses and neutralizing activities in response to SARS-CoV-2 infection are not yet clear. Here we quantify immunoglobulin M (IgM) G (IgG) antibodies recognizing the receptor-binding domain (RBD) of spike (S) or nucleocapsid (N) protein, during a period 6 months from COVID-19 disease onset 349 symptomatic patients who were among first be infected world-wide. The positivity rate magnitude IgM-S IgG-N increase rapidly. High levels IgM-S/N IgG-S/N at 2-3 weeks...
Kindlins and talins are integrin-binding proteins that critically involved in integrin activation, an essential process for many fundamental cellular activities including cell-matrix adhesion, migration, proliferation. As FERM-domain-containing proteins, kindlins, respectively, bind different regions of β-integrin cytoplasmic tails. However, compared with the extensively studied talin, little is known about how kindlins specifically interact integrins synergistically enhance their activation...
Abstract Breast cancer (BC) affects the breast tissue and is second most common cause of mortalities among women. Ferroptosis an iron-dependent cell death mode that characterized by intracellular accumulation reactive oxygen species (ROS). We constructed a prognostic multigene signature based on ferroptosis-associated differentially expressed genes (DEGs). Moreover, we comprehensively analyzed role miRNAs, lncRNAs, immune responses. A total 259 ferroptosis-related were extracted. KEGG...
Major advances have been made in understanding the dynamics of humoral immunity briefly after acute coronavirus disease 2019 (COVID-19). However, knowledge concerning long-term kinetics antibody responses convalescent patients is limited. During a one-year period post symptom onset, we longitudinally collected 162 samples from 76 and quantified IgM IgG antibodies recognizing nucleocapsid (N) protein or receptor binding domain (RBD) spike (S). After one year, approximately 90% recovered still...
Abstract Background Patients with severe Coronavirus Disease 2019 (COVID-19) will progress rapidly to acute respiratory failure or death. We aimed develop a quantitative tool for early predicting mortality risk of patients COVID-19. Methods 301 confirmed COVID-19 admitted Main District and Tumor Center the Union Hospital Huazhong University Science Technology (Wuhan, China) between January 1, 2020 February 15, were enrolled in this retrospective two-centers study. Data on patient demographic...
Abstract Long-term antibody responses and neutralizing activities following SARS-CoV-2 infections have not yet been elucidated. We quantified immunoglobulin M (IgM) G (IgG) antibodies recognizing the receptor-binding domain (RBD) of spike (S) or nucleocapsid (N) protein, during a period six months COVID-19 disease onset in 349 symptomatic patients, which were among first world-wide being infected. The positivity rate magnitude IgM-S IgG-N increased rapidly. High levels IgM-S/N IgG-S/N at 2-3...
We aimed to report the epidemiological and clinical characteristics of hospitalized patients with coronavirus disease-19 (COVID-19) in Zengdu District, Hubei Province, China.Clinical data on COVID-19 inpatients Hospital from January 27 March 11, 2020 were collected; this is a community hospital an area surrounding Wuhan supported by volunteer doctors. All included study. The findings, features, laboratory radiologic manifestations, outcomes these analyzed. followed up for until 22, 2020....
We perform an analysis of the $b\to cτν$ data, including $R(D^{(*)})$, $R(J/ψ)$, $P_τ(D^{*})$ and $F_L^{D^*}$, within beyond Standard Model (SM). fit $B\to D^{(*)}$ hadronic form factors in HQET parametrization to lattice light-cone sum rule (LCSR) results, applying general strong unitarity bounds corresponding $J^P=1^-$, $1^+$, $0^-$ $0^+$. Using obtained relations between helicity amplitudes, we give on individual which can be used BGL fits. fitted taking into account most recent Belle...
Transition metal dichalcogenides have been the most attractive two-dimensional layered materials for electrocatalytic hydrogen evolution due to their unique structure and multi-phase electronic states. However, enhancement of WSe2 reaction (HER) performance by bimetal co-doping has rarely reported. Herein, NiMo-WSe2 catalyst synthesized a one-step hydrothermal reaction, with lower overpotentials 177 188 mV at current density 10 mA cm-2 in 0.5 M H2SO4 1 KOH, respectively. The large specific...
Abstract Various substances in the blood plasma serve as prognostic indicators of progression COVID-19. Consequently, multi-omics studies, such proteomic and metabolomics, are ongoing to identify accurate biomarkers. Cytokines chemokines, which crucial components immune inflammatory responses, play pivotal roles transition from mild severe illness. To determine relationship between cytokines COVID-19, we used four study cohorts perform a systematic cytokine levels patients with different...
The aerial parts of Paederia scandens (Lour.) Merr. were extracted with water and the extract was isolated purified through systematic chromatographic separation. Twenty-one coumarins, including six previously undescribed ones, obtained. Their structures elucidated based on comprehensive analyses NMR, HR-ESI-MS, ECD data. anti-neuroinflammatory activities compounds evaluated using an LPS-induced neuroinflammation model in BV-2 microglia cells. Fraxin methyl ether (2) exhibited notable...
ABSTRACT Stanford type A aortic dissection (TAAD) is a life‐threatening disease. This study explored the role of LIM domain binding 3 (LDB3) in TAAD progression. Four datasets from Gene Expression Omnibus were analyzed to identify TAAD‐related hub genes. LDB3 single nucleotide polymorphisms (SNPs) assessed UK Biobank. Western blotting and immunofluorescence detected expression angiotensin II (Ang II) stimulated human vascular smooth muscle cells (HA‐VSMC), samples, murine model....
We combined catalytic hairpin assembly (CHA) with the Cas12a system for detecting melamine adulteration. This involved two-step signal conversion and two-level amplification, boosting sensor's versatility sensitivity. The sensor showed excellent specificity applicability detection in dairy products, was broadened to viral nucleic acid detection.
The aberrant expression levels of microRNAs (miRNAs) are tightly linked with the initiation and development various diseases genetic disorders. Here, we reported a catalytic-hairpin-assembly-assisted DNA tetrahedron nanoprobe for intracellular miRNA detection. target initiated catalytic-hairpin-assembly reaction between nanoprobes to generate large clusters an enhanced fluorescence resonance energy transfer Cy3 Cy5 dyes. proposed were capable visualizing spatial distributions in living...
We revisit QCD calculations of radiative heavy meson decay form factors by including the subleading power corrections from twist-two photon distribution amplitude at next-to-leading-order in αs with method light-cone sum rules (LCSR). The desired hard-collinear factorization formula for vacuum-to-photon correlation function interpolating currents two mesons is constructed operator- product-expansion technique presence evanescent operators. Applying back- ground field approach, higher twist...
Intravascular transplantation of human-induced pluripotent stem cells (hiPSCs) demonstrated a significant therapeutic effect in the treatment restenosis by paracrine function extracellular vesicles (EVs). However, risk tumorigenicity and poor cell survival limits its clinical applications. In this study, we for first time applied highly efficient robust three-dimensional (3D) protocol hiPSC differentiation into endothelial (ECs) with subsequent isolation EVs from derived hiPSC-EC (ECs...