A5100330973- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- Mitochondrial Function and Pathology
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- RNA and protein synthesis mechanisms
- Advanced biosensing and bioanalysis techniques
- CRISPR and Genetic Engineering
- Extracellular vesicles in disease
- RNA Interference and Gene Delivery
- Single-cell and spatial transcriptomics
- Ion channel regulation and function
- Ubiquitin and proteasome pathways
- Genetics and Neurodevelopmental Disorders
- Cancer-related gene regulation
- Biochemical Acid Research Studies
- Inflammasome and immune disorders
- Immune cells in cancer
- Cell Image Analysis Techniques
- Multiple Myeloma Research and Treatments
- Advanced Fluorescence Microscopy Techniques
- Electrospun Nanofibers in Biomedical Applications
- 3D Printing in Biomedical Research
- Connexins and lens biology
Qingdao University
2020-2025
Anhui Medical University
2022-2025
Guilin University of Technology
2024-2025
Shantou University
2025
First Affiliated Hospital of Anhui Medical University
2025
Affiliated Hospital of Qingdao University
2020-2024
University of Electronic Science and Technology of China
2024
National Health and Family Planning Commission
2024
First People's Hospital of Kunshan
2022-2024
Jiangsu University
2022-2024
Abstract The Cell Tracking Challenge is an ongoing benchmarking initiative that has become a reference in cell segmentation and tracking algorithm development. Here, we present significant number of improvements introduced the challenge since our 2017 report. These include creation new segmentation-only benchmark, enrichment dataset repository with datasets increase its diversity complexity, silver standard corpus based on most competitive results, which will be particular interest for...
Abstract Background Emerging research has reported that circular RNAs (circRNAs) play important roles in cardiac cell death after myocardial ischemia and reperfusion (I/R). Ferroptosis, a new form of discovered recent years, been proven to participate the regulation I/R. This study used circRNA sequencing explore key ferroptosis I/R mechanisms potential function. Methods We performed circRNAs differentially expressed quantitative polymerase chain reactions determine expression different...
Circular RNAs (circRNAs) are differentially expressed in various cardiovascular disease including myocardial ischemia-reperfusion (I/R) injury. However, their functional impact on cardiomyocyte cell death, particular, necrotic forms of death remains elusive. In this study, we found that the level mmu_circ_000338, a cardiac- necroptosis-associated circRNA (CNEACR), was reduced hypoxia-reoxygenation (H/R) exposed cardiomyocytes and I/R-injured mice hearts. The enforced expression CNEACR...
Epithelial–mesenchymal transition (EMT) and dysregulated microRNAs (miRNAs) have important roles in driving chemoresistance. We previously reported that iASPP is a key EMT inducer could increase cisplatin resistance cervical cancer (CC) cells. Herein, we investigate the downstream mechanisms through which contributes to CC. By using lentiviral system, investigated effects of knockdown on CC cell growth chemosensitivity cells vivo. examined if miR-20a, was up-regulated following...
Members of the gasdermin (GSDM) family are pore-forming effectors that cause membrane permeabilization and pyroptosis, a lytic proinflammatory type cell death. To reveal functional evolution GSDM-mediated pyroptosis at transition from invertebrates to vertebrates, we conducted characterization amphioxus GSDME (BbGSDME) found it can be cleaved by distinct caspase homologs, yielding N253 N304 termini with functions. The fragment binds membrane, triggers inhibits bacterial growth, while...
Excessive extracellular glutamate leads to neuronal death in central nervous system. Excitatory transporter subtype 2 (GLT-1) carries bulk of reuptake cerebral ischemia. Although GLT-1 expression fluctuates during the period ischemia, little is known about its regulatory mechanism. Here we show an up-regulation via mammalian target rapamycin (mTOR)-Akt-nuclear factor-кB (NF-кB) signaling cascade oxygen glucose deprivation (OGD). We found that brief treatment significantly increased cultured...
Abstract. Measurements of atmospheric peroxides were made during Wangdu Campaign 2014 at Wangdu, a rural site in the North China Plain (NCP) summer 2014. The predominant detected to be hydrogen peroxide (H2O2), methyl hydroperoxide (MHP) and peroxyacetic acid (PAA). observed H2O2 reached up 11.3 ppbv, which was highest value compared with previous observations time. A box model simulation based on Master Chemical Mechanism constrained by simultaneous physical parameters chemical species...
TIMM44 (translocase of inner mitochondrial membrane 44) is essential for the maintenance functions.Bioinformatics studies and results from local high-grade glioma tissues showed that mRNA protein levels are elevated in glioma, correlating with poor overall survival.Mitochondrial upregulation was also detected patient-derived primary cells immortalized cell line.In established cells, depletion, using lentiviral shRNA strategy or CRISPR/Cas9 knockout (KO) method, robustly inhibited viability,...
Intravascular transplantation of human-induced pluripotent stem cells (hiPSCs) demonstrated a significant therapeutic effect in the treatment restenosis by paracrine function extracellular vesicles (EVs). However, risk tumorigenicity and poor cell survival limits its clinical applications. In this study, we for first time applied highly efficient robust three-dimensional (3D) protocol hiPSC differentiation into endothelial (ECs) with subsequent isolation EVs from derived hiPSC-EC (ECs...
Abstract Chondrocyte senescence is a critical pathological hallmark of osteoarthritis (OA). Aberrant mechanical stress considered pivotal determinant in chondrocyte aging; however, the precise underlying mechanism remains elusive. Our findings demonstrate that SPI1 plays significant role counteracting and inhibiting OA progression. binds to PERK promoter, thereby promoting its transcriptional activity. Importantly, PERK, rather than GCN2, facilitates eIF2α phosphorylation, activating...
Neurons critically depend on the long-distance transport of mitochondria. Motor proteins kinesin and dynein control anterograde retrograde mitochondrial transport, respectively in axons. The regulatory molecules that link them to mitochondria need be better characterized. Nuclear distribution (Nud) family LIS1, Ndel1 NudCL are critical components cytoplasmic complex. Roles these Nud neuronal unknown. Here we report distinct functions axonal cultured hippocampal neurons. We found LIS1...
Heat shock protein (HSP)60 is primarily a mitochondrial protein. Previous experiments have found that changes in the location of intracellular HSP60 been associated with apoptosis. Extracellular mediates apoptosis via its ligand, Toll‑like receptor (TLR)‑4. TLR‑4 an important factor expressed on microglia, central role generating neuroimmune responses pathogenesis neurodegenerative disorders. Naloxone highly effective nonselective opioid antagonist, and has reported to be pharmacologically...