A5101545031- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Viral Infections and Immunology Research
- Viral gastroenteritis research and epidemiology
- COVID-19 and healthcare impacts
- interferon and immune responses
- Mechanical Circulatory Support Devices
- Inflammasome and immune disorders
- Intensive Care Unit Cognitive Disorders
- Circular RNAs in diseases
- Piperaceae Chemical and Biological Studies
- Congenital Diaphragmatic Hernia Studies
- S100 Proteins and Annexins
- Metallurgy and Material Forming
- Bacillus and Francisella bacterial research
- Sepsis Diagnosis and Treatment
- Advanced Technologies in Various Fields
- Textile materials and evaluations
- Quantum, superfluid, helium dynamics
- Atomic and Subatomic Physics Research
- Virology and Viral Diseases
- Thermal Regulation in Medicine
- Cytomegalovirus and herpesvirus research
- Immune Response and Inflammation
- Drug-Induced Hepatotoxicity and Protection
Huazhong University of Science and Technology
2020-2025
Jinyintan Hospital
2015-2024
Wuhan Institute of Virology
2022-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2024
Chinese Academy of Sciences
2022-2023
Hubei Provincial Center for Disease Control and Prevention
2023
Renmin Hospital of Wuhan University
2020
Wuhan Pulmonary Hospital
2020
Wuhan University
2020
Tongji Hospital
2020
Abstract Various substances in the blood plasma serve as prognostic indicators of progression COVID-19. Consequently, multi-omics studies, such proteomic and metabolomics, are ongoing to identify accurate biomarkers. Cytokines chemokines, which crucial components immune inflammatory responses, play pivotal roles transition from mild severe illness. To determine relationship between cytokines COVID-19, we used four study cohorts perform a systematic cytokine levels patients with different...
Introduction Acute respiratory distress syndrome and acute lung injury (ARDS/ALI) still lack a recognized diagnostic test pharmacologic treatments that target the underlying pathology. Methods To explore sensitive non-invasive biomarkers associated with pathological changes in of direct ARDS/ALI, we performed an integrative proteomic analysis blood samples from lipopolysaccharide (LPS)-induced ARDS mice COVID-19-related patients. The common differentially expressed proteins (DEPs) were...
Enterovirus 71 (EV71) is the major pathogen responsible for hand, foot, and mouth disease (HFMD) outbreaks; to date, there no specific anti-EV71 agent. HSP90 a crucial host factor viral life cycle an ideal therapeutic target limiting proliferation. However, role of in EV71-related signaling pathways agents targeting remains unclear. This study aimed verify involved EV71 replication investigate antiviral effects small molecule VER-50589, potent inhibitor, against both vitro vivo. Viral plaque...
Enterovirus 71 (EV71) poses a serious threat to human health, with scattered outbreaks worldwide. There are several vaccines against few EV71 strains but no efficient drug for the treatment of infection. Therefore, it is urgent and significance develop anti-EV71 drugs. Here, we found that PLX8394, RAF inhibitor, possesses high antiviral activity in vitro, being superior traditional clinical ribavirin. Moreover, PLX8394 exhibits broad-spectrum enteroviruses. Notably, suckling mouse model,...
Enterovirus 71 (EV71), a small, single-stranded, positive-sense RNA virus belonging to the enterovirus genus in family Picornaviridae, causes hand, foot, and mouth disease. Although EV71 seriously threatens public health, no effective antiviral drugs are available for treating this In study, we found that ML390, dihydroorotate dehydrogenase inhibitor, has potential anti-EV71 activity. ML390 dose-dependently inhibited replication with IC50 selectivity index values of 0.06601 μM 156.5,...
<p indent="0mm">Textiles play an extremely important role in various aspects of our life since prehistoric times. Toward passionate and imperceptible sport health, people have begun to explore evolving functions beyond the basic values textiles. Smart textiles with such as communication, sensing, color change, warming, cooling, actuation, computing become new frontier wearable technology. Global warming enormously scorching weather adversely affected human production living well sustainable...
Medical education plays an important role in promoting the development of global medical science. Nevertheless, intrinsic gap existing between institutional teaching and practical clinical tasks causes low efficiency students’ weak initiative. Recent developments sensing fabric embedded computing, along with advances Artificial intelligence (AI) digital twin technology are paving way for transformation research towards digitization. In this work, we present intelligent space based on novel...
Abstract Background The coronavirus disease 2019 (COVID-19) pandemic has led to surges in the demand for extracorporeal membrane oxygenation (ECMO) therapy. However, little in-depth evidence is known about application of ECMO therapy COVID-19 patients. Methods This retrospective multicenter cohort study included 88 patients who had been diagnosed with and received at seven designated hospitals Wuhan, China. clinical characteristics, laboratory examinations, treatments, outcomes were...
ABSTRACT Objective: The Coronavirus Disease 2019 (COVID-19) is a recently-emerging infectious disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), posing significant threat to public health around world. In patients with COVID-19, kidney injury (AKI) common complication associated poor prognoses. We analyzed co-expressed genes explore relationships between SARS-CoV2 infection and AKI, revealed potential biomarkers therapeutic targets of COVID-19-associated...
Background: Currently, little in-depth evidence is known about the therapeutic considerations and outcomes of extracorporeal membrane oxygenation (ECMO) therapy in coronavirus disease 2019 (COVID-19) patients. Methods: This retrospective multicenter cohort study included patients with COVID-19 received ECMO at seven designated hospitals Wuhan, China. The were followed until April 30, 2020. clinical characteristics, laboratory examinations, treatments, extracted from electronic medical...
Objective The outbreak of COVID-19 in 2020 is reminiscent the H7N9 2013, which poses a huge threat to human health. We aim compare clinical features and survival factors fatal cases H7N9. Methods Data on confirmed identified mainland China were analyzed demographic characteristics severity. Survival curves estimated by Kaplan–Meier method compared using log-rank tests restricted mean time model. A Cox regression model was used identify Results Similar observed proportion receiving...