Background The current study was performed to investigate whether circulating cell‐free Epstein‐Barr virus DNA (cfEBV DNA) would be useful for posttreatment surveillance in patients with nasopharyngeal carcinoma (NPC). Methods authors identified a total of 1984 nondisseminated NPC from an institutional big‐data research platform. Blood samples were collected within 3 months the completion radiotherapy and every 12 thereafter cfEBV analysis. Patients followed until disease recurrence detected...

Stroke-associated pneumonia (SAP) is a common complication leading to death and disability after stroke. Currently, more studies tend focus on stroke-associated in patients with ischemic stroke, while there are few predictors of intracerebral hemorrhage-associated (ICHAP). It necessary discover new build accurate prediction models for ICHAP. We continuously collected 498 acute hemorrhage then divided them into ICHAP non-ICHAP groups. Then we conducted univariate analyses multivariate...

Tobacco use has been confirmed to be a risk factor for postoperative complications, but the impact of smoking on adverse outcomes following thyroidectomy remains largely unknown. Using data spanning 2016–2020 from National Inpatient Sample, patients aged ≥ 18 years who underwent thyroid malignancy or other disorders were identified and classified into two groups: current smokers non-smokers. We compared outcome variables between groups via univariate analysis adjusted multivariate logistic...

Abstract Previous studies have shown that vitamin D3 may be a potential factor in insulin resistance, but the relationship between and resistance still remains controversial. At present, more research is needed to explore resistance. The samples from 2009 2018 NHANES database were analyzed Investigate mechanism. We performed cross-sectional study of five periods database. Finally, 9298 participants selected through strict inclusion exclusion criteria, Multivariate logistic regression...

Although previous studies have found that maternal smoking decreases the risk of pregnancy-induced hypertension (PIH), difference this effect between primiparous and multiparous women has not been well studied results exposure-response relationships PIH are inconsistent. No study specifically examined relationship eclampsia.We analysed data from a population-based retrospective cohort 3 153 944 singleton pregnancies in US. The were derived national linked birth/infant mortality database for...

Abstract Background: Although a variety of risk factors pneumonia after clipping or coiling the aneurysm (post-operative [POP]) in patients with aneurysmal subarachnoid hemorrhage (aSAH) have been studied, predictive model POP aSAH has still not well established. Thus, aim this study was to assess feasibility using admission neutrophil lymphocyte ratio (NLR) predict occurrence patients. Methods: We evaluated 711 who were enrolled prospective observational and collected blood cell counts...

Abstract Nuclear paraspeckle assembly transcript 1 (NEAT1) has been found to be dysregulated and associated with clinical progression in various human cancers. The prognostic value of NEAT1 nasopharyngeal carcinoma (NPC) was still controversial. aim our study provide more sufficient evidence that expression is correlated overall survival patients NPC. detected NPC tissue samples, the relationship between parameters, including prognosis, analyzed. meta‐analysis performed further assess...

Objective To explore the clinical characteristics, renal histopathological spectrum and prognostic factors of biopsy-proven kidney diseases in elderly. Methods A retrospective observational study was conducted elderly patients who had received biopsies. Demographic, pathological data at time biopsy were collected from medical records. Follow-up records studied. Results The (≥60 years) accounted for 74 434 (17.1%) native biopsies that performed a 9-year period. In cohort included ( n = 72),...

Objective: The endovascular filament-perforation model turned out to become the most popular one for reproduction of prominent pathophysiological features observed after human subarachnoid haemorrhage (SAH). However, few studies have considered methods that may minimize surgically induced injury. This study described an improved and simplified surgical procedure in which a single clip is placed at external carotid artery (ECA).Method: Male C57BL/6 mice were given either classic filament SAH...

Objective To study the effect of augmented renal clearance (ARC) on vancomycin therapeutic drug monitoring in patients undergoing neurosurgery. Methods A retrospective observational analysis was conducted a neurosurgery department from January 2019 to June 2019. Patients were assigned normal function or ARC group. The baseline characteristics, data, and prognosis compared analyzed. Results In total, 104 enrolled, including 78 26 groups, respectively. There significant differences age,...

We aimed to investigate potential causal associations between serum 25-hydroxyvitamin D (25(OH)D) levels and incidence of lung cancer overall histologic types. performed a Mendelian randomisation analysis using prospective cohort study in Norway, including 54 580 individuals 676 incident cases. A 25(OH)D allele score was generated based on the vitamin D-increasing alleles rs2282679, rs12785878 rs10741657. Hazard ratios with 95% confidence intervals for types were estimated relation score....

Abstract Limited studies have triangulated the relationship between serum 25-hydroxyvitamin D [25(OH)D] levels and systolic blood pressure (SBP), diastolic (DBP) or hypertension risk utilizing both observational Mendelian randomization (MR) approaches. We employed data from Norwegian Trøndelag Health Study (HUNT) to conduct cross-sectional (n = 5854) prospective 3592) analyses, as well one-sample MR 86,324). also used largest publicly available for two-sample MR. Our analyses showed a 25...

This study aims to establish an integrated model based on clinical, laboratory, radiological, and pathological factors predict the postoperative recurrence of atypical meningioma (AM).A retrospective 183 patients with AM was conducted. Patients were randomly divided into a training cohort (n = 128) external validation 55). Univariable multivariable Cox regression analyses, least absolute shrinkage selection operator (LASSO) analysis, time-dependent receiver operating characteristic (ROC)...

Objective: Early identification for the need of tracheostomy (TT) in aneurysmal subarachnoid hemorrhage (aSAH) patients remains one main challenges clinical practice. Our study aimed to establish and validate a nomogram model predicting postoperative TT aSAH patients. Methods: Patients with receiving active treatment (interventional embolization or clipping) our institution between June 2012 December 2018 were retrospectively included. The effects patients' baseline information, aneurysm...

Background: Chronic obstructive pulmonary disease (COPD) is a serious with impaired quality of life (QoL). Few studies have focused on the QoL for mild COPD patients in Chinese urban communities. This study aimed to evaluate and explore its associated factors among Shanghai. Methods: A cross-sectional survey 275 was conducted 6 communities Pudong New Area Shanghai, China, 2016. Data socioeconomic health conditions were acquired through face-to-face interview physical examination. EuroQoL...

To evaluate the effect of therapeutic drug monitoring (TDM) vancomycin in neurosurgery patients.In this retrospective, single-center cohort study, data were collected from patients administered after during 2020. Intervention by a pharmacist using an area under curve (AUC)-based strategy for TDM was started on 1 July The trough concentration monitored previously. Data regarding basic demographics, application, and analyzed.Ninety 155 samples included non-intervention intervention groups,...

Abstract Objective Placenta accreta spectrum disorder (PAS) is a serious obstetric complication associated with significant maternal morbidity and mortality. Prophylactic balloon occlusion (PBO), as an intravascular interventional therapies, has emerged potential management strategy for controlling massive hemorrhage in patients PAS. However, current evidence about the clinical application of PBO PAS are still controversial. This study aimed to evaluate effectiveness safety Methods A...

<title>Abstract</title> Objectives To investigate the relationship between ganciclovir trough concentration and its clinical efficacy safety in patients with pulmonary cytomegalovirus (CMV) infection. evaluate target value of therapeutic drug monitoring (TDM) for predicting or toxicity. Methods An observational study was conducted on CMV lung infection Jan 2021 Dec 2023. Target concentrations were collected during TDM outcomes adverse events (AEs) assessed. Multiple regression analyses...

Objective To compare the occurrence and prognosis of antibiotic-associated diarrhea (AAD) between patients treated with cefoperazone/sulbactam piperacillin/tazobactam in neurosurgery department. Methods This study retrospectively analyzed who received or to prevent treat hospital-acquired infections Department Neurosurgery The First Medical Center Chinese PLA General Hospital October 2019 2020. For AAD, clinical data, antibiotic usage, incidence diarrhea, treatment, were collected analyzed....