A5102752633- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Thyroid Disorders and Treatments
- Ferroptosis and cancer prognosis
- Endoplasmic Reticulum Stress and Disease
- Glycosylation and Glycoproteins Research
- RNA modifications and cancer
- Breast Lesions and Carcinomas
- ATP Synthase and ATPases Research
- Breast Cancer Treatment Studies
- Wnt/β-catenin signaling in development and cancer
- Cardiac Ischemia and Reperfusion
- Sarcoma Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Circular RNAs in diseases
- Microtubule and mitosis dynamics
- HER2/EGFR in Cancer Research
- Ion channel regulation and function
- Protease and Inhibitor Mechanisms
- Diet, Metabolism, and Disease
- Reproductive Biology and Fertility
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
Bristol-Myers Squibb (United States)
2021
Huashan Hospital
2019
Fudan University
2019
Shandong Provincial Hospital
2019
Shandong University
2010-2019
Jinan University
2019
Sinopharm Gezhouba Central Hospital
2018
Nantong University
2014-2015
Guangdong Medical College
2012-2015
Affiliated Hospital of Nantong University
2014-2015
Let-7a has been shown to play important roles in nasopharyngeal carcinoma (NPC) cell proliferation and apoptosis, but little is known about the function mechanism of let-7a metastasis. We aimed investigate metastasis clarified regulation high mobility group A2 (HMGA2) by let-7a. The expression levels HMGA2 were examined NPC clinical specimens using quantitative reverse transcription-PCR (RT-qPCR). was confirmed as a target through luciferase reporter assays, RT-qPCR, Western blotting....
Subclinical hypothyroidism (SCH) and diabetes mellitus are closely related often cluster in individuals. However, this connection is still uncertain, as well the underlying mechanism. In study, we firstly re-analyzed data of a mature database (NHANES, 1999 ~ 2002) found that both fasting plasma glucose levels proportion hyperglycemic subjects SCH patients were higher than those euthyroid controls. And was associated with 2.29-time increased risk for diabetes. Then, established an mouse model...
Abstract Nuclear paraspeckle assembly transcript 1 (NEAT1) has been found to be dysregulated and associated with clinical progression in various human cancers. The prognostic value of NEAT1 nasopharyngeal carcinoma (NPC) was still controversial. aim our study provide more sufficient evidence that expression is correlated overall survival patients NPC. detected NPC tissue samples, the relationship between parameters, including prognosis, analyzed. meta‐analysis performed further assess...
Abstract IRI of a transplanted heart may result in serious early and late disadvantageous effects such as increased allograft immunogenicity, primary graft dysfunction, initiation fibroproliferative cascades that compromise the survival recipient. Sgk‐1 has recently been linked to cell growth survival. It reported through renal transplantation model, Dexa increases expression therefore protects from . In our current study, we aim assess its protective on cardiomyocyte after transplantation....
Clear cell renal carcinoma (ccRCC) is the most common type of cancer parenchyma. MicroRNAs (miRNAs) are non‑coding RNAs ~22 nucleotides in length, which function as post‑transcriptional regulators. Recently, downregulation miRNA (miR)‑492 was observed to be associated with ccRCC; however, molecular mechanism by miR‑492 inhibited ccRCC remained elucidated. In present study, it demonstrated that markedly downregulated tissues when compared adjacent normal tissues, determined reverse...
Mitochondrial fragmentation drastically regulates the viability of pancreatic cancer through a poorly understood mechanism. The present study used erlotinib to activate mitochondrial and then investigated downstream events that occurred in response fragmentation. Cell apoptosis were determined via MTT assay, TUNEL staining ELISA. was measured an immunofluorescence assay qPCR. siRNA transfection pathway blockers perform loss-of-function assays. results our demonstrated treatment mediated cell...
Numb is an adaptor protein that controls the fate of cells in different species through asymmetrical inheritance by sibling during division. It has been investigated extensively mitosis, mostly neural progenitor cells, but its function meiosis remains unknown. The present study was designed to investigate expression, subcellular localisation and functional roles mouse oocyte meiotic maturation. Using real-time polymerase chain reaction western blotting, we found expression increased from...
Subclinical hypothyroidism (SCH) is becoming a global health problem because of its increasing prevalence and potential adverse effects, including cardiovascular diseases nonalcoholic fatty liver disease. However, the association remains controversial. MicroRNAs (miRNAs) have been shown to be implicated in lipid metabolism disorders. But how miRNAs regulate hepatic SCH unknown. We investigated miRNA alterations proteome profiles mouse model, which were generated with methimazole(MMI) for 16...