A5101886865- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Liver Disease and Transplantation
- Ovarian function and disorders
- Liver Disease Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Esophageal Cancer Research and Treatment
- Sepsis Diagnosis and Treatment
- Pulmonary Hypertension Research and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Function and Risk Factors
- Urinary and Genital Oncology Studies
- Infective Endocarditis Diagnosis and Management
- Housing Market and Economics
- Vitamin D Research Studies
- Sex and Gender in Healthcare
- Porphyrin Metabolism and Disorders
- Occupational and environmental lung diseases
- Pleural and Pulmonary Diseases
- Bladder and Urothelial Cancer Treatments
- Liver Diseases and Immunity
- Orthopedic Infections and Treatments
- Ultrasound and Hyperthermia Applications
Sun Yat-sen University
2022-2024
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
2024
Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai)
2024
Brigham and Women's Hospital
2022-2024
The University of Tokyo
2023-2024
Sun Yat-sen Memorial Hospital
2022-2023
Shaanxi University of Chinese Medicine
2021-2022
Xi'an Jiaotong University
2022
Shanghai First People's Hospital
2021
Shanghai Jiao Tong University
2021
Lipotoxic hepatocyte-derived exosomal miR-1297 promotes hepatic stellate cell activation through the PTEN signaling pathway in metabolic-associated fatty liver disease
The role of exosome-mediated mitophagy in the crosstalk between hepatocytes (HCs) and hepatic stellate cells (HSCs) metabolic-associated fatty liver disease (MAFLD) remains unknown. Serum exosomal miR-27a levels were markedly increased positively correlated with fibrosis MAFLD patients mice. Exosomal was released from lipotoxic HCs specifically transmitted to recipient-activated HSCs. PINK1, key target miR-27a, primarily mediates mitophagy. Overexpression or knockdown PINK1 HC-exosomal...
Abstract Previous studies have shown that vitamin D3 may be a potential factor in insulin resistance, but the relationship between and resistance still remains controversial. At present, more research is needed to explore resistance. The samples from 2009 2018 NHANES database were analyzed Investigate mechanism. We performed cross-sectional study of five periods database. Finally, 9298 participants selected through strict inclusion exclusion criteria, Multivariate logistic regression...
Abstract Background Increasing evidence has demonstrated that long noncoding RNAs (lncRNAs) have regulatory functions in hepatocellular carcinoma (HCC). The link between lincSCRG1 and HCC remains unclear. Methods To explore the regulation axis, bioinformatics, RIP luciferase reporter assay were performed. expressions of lincSCRG1-miR26a-SKP2 detected tissues cell lines through qPCR western blot. cells investigated vitro assays (MTT, colony formation, transwell flow cytometry) inner effect...
Abstract Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women reproductive age, but its pathology has not been fully characterized and optimal treatment strategy remains unclear. Cellular senescence a permanent state cell-cycle arrest that can be induced by multiple stresses. Senescent cells contribute to pathogenesis various diseases, owing an alteration secretory profile, termed ‘senescence-associated phenotype’ (SASP), including with respect...
Two Gram-stain-negative, aerobic, milk-white coloured, non-motile, short rod-shaped bacteria, designated as strains SYSU D60010 T and D60012 , were isolated from sand samples collected the Taklimakan Desert of Xinjiang Province in China. Both positive for oxidase, catalase nitrate reduction, but negative amylase, H 2 S production, hydrolysis gelatin cellulase. Strains grew well at 28 °C, pH 7 had same NaCl tolerance range 0–1 % (w/v). The major fatty acids (>5 %) summed feature 8 (C 18 :...
Eikenella corrodens is a part of the inherent flora on surface human mucosa. It usually does not cause disease unless patient has been bitten, injured or surgically infected. Lumbar spine infection caused by presents with conventional symptoms such as low back pain and fever. Herein, we report case lumbar intervertebral space presented abdominal pain.A 38-year-old man no medical history note pain. Initially, local doctors suspected that had disease. However, diseases were ruled out only was...
A survival benefit was observed in metastatic bladder cancer patients who underwent primary tumor resection, but it still confusing which are suitable for the surgery. For this purpose, we developed a model to screen stage M1 would from resection.Patients with were screened Surveillance, Epidemiology, and End Results database (2004-2016) then divided into surgery (partial or complete cystectomy) group non-surgery group. To balance characteristics between them, 1:1 propensity score matching...
Abstract Background Renal ischemia–reperfusion injury (IRI) frequently occurs clinically. We investigated the value of contrast-enhanced ultrasonography (CEUS) in evaluation renal IRI levels mice. Methods Thirty-six healthy adult male C57BL/6 mice (20–22 g) were randomly divided into sham, 10 min, 20 30 40 and 50 min groups based on time warm ischemia by blocking left pedicle, approved Institutional Animal Ethics Committee. Time-intensity curve (TIC)-derived parameters such as peak...
Abstract Background: Sepsis remains the leading cause of death in ICU. There is still controversy about association between TG, HDL and TG/HDL sepsis. Our aim was to explore relationship HDL, hospitalized mortality sepsis by using MIMIC-IV database.Methods: Selected from patients admitted database (2008-2019). A total 1032 eligible participants were included. Multivariate Cox regression model used analyze correlation hospitalization after excluding potential confounding factors, smooth curve...