A5101473461- Transplantation: Methods and Outcomes
- Renal Transplantation Outcomes and Treatments
- Microtubule and mitosis dynamics
- Extracellular vesicles in disease
- Viral Infections and Immunology Research
- Traditional Chinese Medicine Analysis
- Pneumocystis jirovecii pneumonia detection and treatment
- Organ Transplantation Techniques and Outcomes
- Lung Cancer Treatments and Mutations
- HIV Research and Treatment
- Antibiotics Pharmacokinetics and Efficacy
- Glaucoma and retinal disorders
- Chronic Lymphocytic Leukemia Research
- MicroRNA in disease regulation
- Immune cells in cancer
- Systemic Lupus Erythematosus Research
- Cytomegalovirus and herpesvirus research
- Asthma and respiratory diseases
- Corneal surgery and disorders
- Pharmacogenetics and Drug Metabolism
- Virology and Viral Diseases
- Herpesvirus Infections and Treatments
- Atrial Fibrillation Management and Outcomes
- RNA Research and Splicing
- Cancer-related gene regulation
China-Japan Friendship Hospital
2014-2025
Fred Hutch Cancer Center
2013-2025
University of Washington
2021-2025
Seattle University
2025
Jinan University
2022-2025
Pfizer (United States)
2019-2024
Gannan Medical University
2021-2024
First Affiliated Hospital of Gannan Medical University
2021-2024
Chinese Academy of Agricultural Sciences
2023
Institute of Agricultural Resources and Regional Planning
2023
Abstract Pulmonary fibrosis is the pathologic basis for a variety of incurable human chronic lung diseases. IL-17A, glycoprotein secreted from IL-17–producing cells, has recently been shown to be proinflammatory cytokine involved in inflammation and autoimmune disease. In this study, we report that IL-17A increased synthesis secretion collagen promoted epithelial–mesenchymal transition alveolar epithelial cells TGF-β1–dependent manner. Using vivo fibrotic models, found expression elevated...
We previously identified a region of recurrent amplification on chromosome 22q11.21 in subset primary lung adenocarcinomas. Here we show that CRKL, encoding for an adaptor protein, is amplified and overexpressed non-small cell cancer (NSCLC) cells harbor amplifications. Overexpression CRKL immortalized human airway epithelial promoted anchorage-independent growth tumorigenicity. Oncogenic activates the SOS1-RAS-RAF-ERK SRC-C3G-RAP1 pathways. Suppression NSCLC amplifications induced death....
Abstract CRISPR-Cas9 provides the means to perform genome editing and facilitates loss-of-function screens. However, we others demonstrated that expression of Cas9 endonuclease induces a gene-independent response correlates with number target sequences in genome. An alternative approach suppressing gene is block transcription using catalytically inactive (dCas9). Here directly compare by (cutting, CRISPRc) suppression KRAB-dCas9 (CRISPRi) screens identify cell essential genes. CRISPRc...
Hepatocellular carcinoma (HCC) is a devastating consequence of chronic inflammatory liver diseases. The goal this study was to investigate whether Toll-like receptor 4 (TLR4) activity contributes HCC initiation and progression in mice. A mouse model diethylnitrosamine (DEN)-induced generated with wild-type TLR4 mutant mice, the development senescent responses were assessed using morphologic, immunological, biochemical criteria. We found that genetic or pharmacologic blocking increased...
Chromosome instability (CIN) is found in 85% of colorectal cancers. Defects mitotic processes are implicated high CIN and may be critical events tumorigenesis. Shugoshin-1 (SGO1) aids the maintenance chromosome cohesion prevents premature separation CIN. In addition, integrity centrosome compromised due to deficiency Cohesin Sgo1 through disengagement centrioles. We report here generation characterization SGO1-mutant mice show that haploinsufficiency SGO1 leads enhanced colonic Complete...
Abrocitinib is a Janus kinase 1-selective inhibitor for the treatment of moderate-to-severe atopic dermatitis. eliminated primarily by metabolism involving cytochrome P450 (CYP) enzymes. pharmacologic activity attributable to unbound concentrations parent molecule and 2 active metabolites, which are substrates organic anion transporter 3 (OAT3). The sum potency-adjusted exposures abrocitinib its metabolites termed moiety. We evaluated effects CYP inhibition, induction, OAT3 inhibition on...
A similar immune response is implicated in the pathogenesis of pulmonary fibrosis and allergic disorders. We investigated potential therapeutic efficacy mechanism rupatadine, a dual antagonist histamine platelet-activation factor (PAF), bleomycin- (BLM-) silica-induced fibrosis. The indicated dosages rupatadine were administered rodents with bleomycin or tissue injury, fibrosis, inflammatory cells cytokines, lung function examined to evaluate rupatadine. anti-fibrosis effect was compared an...
Polo-like kinase 3 (Plk3), an immediate early response gene product, plays important role in the regulation of mitosis, DNA damage checkpoint activation, and Golgi dynamics. Similar to other members Plk family, Plk3 has a conserved domain at N terminus Polo box consisting two boxes C terminus. In this study, we demonstrate that is sufficient for subcellular localization centrosomes, spindle poles, midbody when ectopically expressed HeLa U2OS cells. Both are required localization....
To investigate, in healthy Asian subjects, the diurnal changes of corneal biomechanical properties hysteresis (CH) and its relation to fluctuations intraocular pressure (IOP) central thickness (CCT) after sleeping.Forty eyes 20 volunteers (4 males 16 females) with a mean age 19.7 +/- 1.1 years were measured modified retinal optical coherence tomography an ocular response analyzer (ORA). CH, CCT, Goldmann-equivalent (IOPg), resistance factor (CRF), compensated (IOPcc) obtained. Repeated...
Simian foamy viruses (SFVs) are ubiquitous in non-human primates (NHPs). As all retroviruses, reverse transcription of SFV leads to recombination and mutation. Because more humans have been shown be infected with than any other simian borne virus, is a potentially powerful model for studying the virology epidemiology at human/NHP interface. In Asia, likely transmitted through macaque bites scratches that occur context everyday life. We analyzed multiple proviral sequences from gag gene both...
Foamy viruses are complex retroviruses that have been shown to be transmitted from nonhuman primates humans. In Bangladesh, infection with simian foamy virus (SFV) is ubiquitous among rhesus macaques, which come into contact humans in diverse locations and contexts throughout the country. We analyzed microsatellite DNA 126 macaques at six sites Bangladesh order characterize geographic patterns of macaque population structure. also included this study 38 owned by nomadic people who train them...