A5100461434- Diabetes, Cardiovascular Risks, and Lipoproteins
- Obesity, Physical Activity, Diet
- Pharmaceutical and Antibiotic Environmental Impacts
- Thyroid Cancer Diagnosis and Treatment
- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Use and Resistance
- Nutritional Studies and Diet
- Thyroid Disorders and Treatments
- Medical Malpractice and Liability Issues
- Health disparities and outcomes
- Pneumonia and Respiratory Infections
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Quality and Safety in Healthcare
- Birth, Development, and Health
- Hormonal Regulation and Hypertension
- Ethics in medical practice
- Antibiotic Resistance in Bacteria
- Chronic Disease Management Strategies
- Health Promotion and Cardiovascular Prevention
- Cardiovascular Disease and Adiposity
- Pediatric health and respiratory diseases
- COVID-19 and Mental Health
- Parkinson's Disease Mechanisms and Treatments
- Health and Wellbeing Research
- Cytomegalovirus and herpesvirus research
Fudan University
2015-2024
Huazhong University of Science and Technology
2022-2024
Karolinska Institutet
2012-2024
Huashan Hospital
2018-2024
Capital Medical University
2009-2024
Peking University
2018-2024
Union Hospital
2024
Beijing Jishuitan Hospital
2018-2024
Air Force Medical University
2024
Tongji University
2022-2024
A variety of antibiotics have been found in aquatic environments, but drinking water and their contribution to antibiotic exposure human are not well-explored. For this, representative samples 530 urine from schoolchildren were selected Shanghai, 21 common (five macrolides, two β-lactams, three tetracyclines, four fluoquinolones, sulfonamides, phenicols) measured urines by isotope dilution two-dimensional ultraperformance liquid chromatography coupled with high-resolution quadrupole...
Abstract Obesity and chronic diet‐related diseases such as type 2 diabetes, hypertension, cardiovascular disease, cancers, celiac are increasing worldwide. The prevalence of these has led nutritionists food scientists to pay more attention the relationship between diet different disease risks. Among foods, rice received because it is a major component billions peoples’ diets throughout world. Rice commonly consumed after polishing or whitening polished grain known high glycemic its starch...
To explore the antibiotic body burden of Chinese school children, total urinary concentrations (free and conjugated) 18 representative antibiotics (5 macrolides, 2 β-lactams, 3 tetracyclines, 4 quinolones, sulfonamides) were measured by ultraperformance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry among 1064 students recruited from economically geographically distinct areas in east China 2013. All detected urine samples with detection frequencies ranging 0.4...
Exposure to antibiotics during pregnancy can pose a systematic effect on human health. A few biomonitoring studies have demonstrated an extensive exposure of children antibiotics, but there is still lack data for pregnant women. To assess the women and potential health risk, we investigated 536 aged 16–42 years from two geographically different study sites in Eastern China 2015. We measured 21 five categories (seven fluoroquinolones, three phenicols, four tetracyclines, macrolides,...
Introduction The COVID-19 pandemic caused a healthcare crisis in China and continues to wreak havoc across the world. This paper evaluated COVID-19’s impact on national regional service utilisation expenditure China. Methods Using big data approach, we collected from 300 million bank card transactions measure individual mainland Since outbreak coincided with 2020 Chinese Spring Festival holiday, difference-in-difference (DID) method was employed compare changes before, during after 2019. We...
An extensive exposure to antibiotics has been demonstrated in children and pregnant women by biomonitoring, but data from general adults remain limited. In the current study, we studied 822 aged 21–75 years Shanghai 2017 analyzed 18 common (five veterinary (VAs), four human (HAs), nine human/veterinary (H/VAs)) spot urine liquid chromatography coupled high-resolution mass spectrometry. All were detected with an overall detection frequency of 45.9% for each ranged 0.1% 15.2%. HAs, VAs, H/VAs,...
This study examined the association of obesity and dyslipidemia according to body measurements among Chinese adults in Shanghai, a place process rapid urbanization. Using baseline data Shanghai Suburban Adult Cohort Biobank (SSACB), subjects completed questionnaires physical examinations, fasting blood was collected for biochemical assays. We estimated odds ratios (OR) 95% confidence interval (CI) by multivariable logistic regression. The prevalence 12.9% 28.8% both general central obesity,...
Pulmonary fibrosis that occurs following lung injury is a progressive and fatal disease since continual damage to tissue triggers the dysregulated inflammation response accompanying abnormal healing process. Pyroptosis of alveolar macrophages has been found play an essential role in deterioration fibrosis. However, lack inhibitors against this inflammatory cell death dense stroma pose major barriers treatment. Herein, we developed albumin-based nanoformulation realize active delivery...
Background Although several studies have evaluated the relationship between bisphenol A (BPA) and thyroid functions, their results are not entirely consistent. Little is known about BPA in relation to volume structure. Methods We examined association of with nodules using data from 718 Chinese children living East Coast China 2012. First morning urine samples were collected for determination urinary BPA, creatinine, iodine concentrations (UIC). Thyroid (TV) assessed by ultrasonography....
Chronic obstructive pulmonary disease (COPD) is a serious frequently accompanied by anxiety and depression. Few studies have focused on depression for mild COPD patients in China. This study aimed to assess the prevalence associated factors among with urban communities. A cross-sectional survey of 275 was conducted 6 communities randomly sampled from Pudong New Area Shanghai, China, 2016. Data socioeconomic health conditions were acquired through face-to-face interview as well physical...
An extensive exposure to antibiotics has been confirmed in children, but the predictors and potential health risk remain unclear. To investigate of urine children Shanghai. We selected 284 school aged 8–11 years from a central area Shanghai, China, 2017. Ultra-performance liquid chromatography coupled with high-resolution mass spectrometry was used measure 20 antibiotics, including four human (HAs), six veterinary (VAs), 10 human/veterinary (H/VAs), three metabolites first morning urine....
Telomerase reverse transcriptase (TERT) promoter mutations have been linked to adverse clinical parameters in thyroid cancer, but TERT-expressing tumours are not always mutated. Little is known regarding other TERT-related genetic aberrations. To delineate the role of TERT gene aberrancies follicular tumours, 95 carcinomas (FTCs), 43 adenomas (FTAs) and 33 uncertain malignant potential (FT-UMPs) were collected. The assayed for expression, mutations, hypermethylation copy number (CN)...
Abstract Background Failure to promote early detection and better management of hypertension will contribute the increasing burden cardiovascular diseases. This study aims assess gender differences in prevalence, awareness, treatment control hypertension, together with its associated factors, China Sweden. Methods We used data from two cross-sectional studies: Västerbotten Intervention Program northern Sweden ( n = 25,511) Shanghai survey eastern (n 25,356). employed multivariable logistic...
To determine the optimal cut-off values and evaluate associations of body mass index (BMI), waist circumference (WC) waist-height ratio (WHtR) with cardiovascular disease (CVD) risk factors.A large-scale cross-sectional survey was conducted among 35,256 adults aged 20-74 years in Shanghai between June 2016 December 2017. Receiver operating characteristic (ROC) analyses were to assess anthropometric indices CVD factors including hypertension, diabetes, dyslipidemia hyperuricemia. Multivariate...
Purpose The Shanghai Suburban Adult Cohort and Biobank (SSACB) was established to identify environmental, lifestyle genetic risk factors for non-communicable chronic diseases (NCDs) in adults (20–74 years old) living a suburban area of with rapid urbanisation. Participants Two eight district were purposely selected according participant willingness, health service facilities, population, geographic region electronic medical record system. From these districts, four communities based on...
Abstract Purpose To investigate associations of five typical lifestyle-related behavioral risk factors (insufficient physical activity, prolonged screen viewing, deprived sleeping, consumption fast food and sugar-sweetened beverage) with health-related quality life (HRQoL) among school students in China. Methods Students aged 9–17 years (grades 4–12) were randomly selected from primary high schools Nanjing, China, to participate this cross-sectional study 2018. The outcome variable, HRQoL,...
Controversy remains regarding the prediction effects of different adiposity measure indicators for risk cardiovascular disease (CVD). Our study aimed to assess associations three traditional anthropometric indicators, namely, waist circumference (WC), waist-to-height ratio (WHtR), and body mass index (BMI) as well non-traditional Chinese visceral (CVAI), lipid accumulation product (LAP), shape (ABSI), with CVD among Southwest population.
TBX1 is a member of the T-box family transcription factors characterized by conserved DNA binding domain termed T-box. has been reported to be downregulated in mouse skin tumors and considered negative regulator tumor cell growth mice. However, its role exact mechanism human cancers, including thyroid cancer, remain totally unknown.Quantitative reverse polymerase chain reaction Western blot assays were performed evaluate expression investigated genes. Methylation-specific pyrosequencing used...