A5103277461- Head and Neck Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Genomic variations and chromosomal abnormalities
- Cancer-related Molecular Pathways
- Lung Cancer Treatments and Mutations
- Tumors and Oncological Cases
- Oral Health Pathology and Treatment
- Cancer-related molecular mechanisms research
- Head and Neck Surgical Oncology
- Cervical Cancer and HPV Research
- Cancer Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Oral health in cancer treatment
- Ear and Head Tumors
- Colorectal and Anal Carcinomas
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Mesenchymal stem cell research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Oral and Maxillofacial Pathology
- Chromatin Remodeling and Cancer
- Genomics and Chromatin Dynamics
- Lymphoma Diagnosis and Treatment
- Chemotherapy-induced organ toxicity mitigation
- Thyroid Cancer Diagnosis and Treatment
Red Glead Discovery (Sweden)
2024-2025
Medicon Village
2024-2025
Lund University
2011-2023
Skåne University Hospital
2014-2023
Scania (Sweden)
2020-2022
Karolinska Institutet
2021
Botsford Hospital
2006
Beaumont Hospital, Royal Oak
2006
Beaumont Hospital, Dearborn
2006
Van Andel Institute
2006
BACKGROUND This case-referent study was conducted to elucidate the role of selected exogenous agents in etiology head and neck cancer. The factors studied were tobacco smoking, alcohol intake, use moist oral snuff, dietary factors, occupational exposures, hygiene. In this first report, authors discuss impact consumption. METHODS base approximately 2 million person-years at risk consisted Swedish males age 40-79 years living geographic regions during 1988-1990. A total 605 cases identified...
Conclusion. Our results show that average and poor oral hygiene inadequate dental status are independent risk factors for oropharyngeal squamous cell carcinoma (OOSCC), irrespective of tobacco alcohol consumption. Objective. To evaluate a possible relationship between cancer, hygiene, status, mucosal lesions some lifestyle in population-based case-control study. Material methods. Between September 2000 January 2004, 132/165 (80%) all incident cases OOSCC 320/396 (81%) the intended eligible...
Abstract Background Positron emission tomography (PET) provides metabolic information of tissues in vivo. The purpose this study was to assess the value PET with 2‐[ 18 F] fluoro‐2‐deoxy‐ D ‐glucose (FDG) prediction therapy outcome (tumor response, survival, and locoregional control) locally advanced HNSCC. Methods Between 1993 1999 47 patients underwent before (PET 1 ) after 2 3 weeks radical treatment evaluation rate (MR) standardized uptake (SUV) FDG. All received radiotherapy, 10 also...
Abstract In several countries, increased incidence of squamous cell carcinoma (SCC) the tongue in young adults has been suspected during last decades. Some reports indicate a lower survival rate for patients compared to older patients. other reports, there not any considerable difference when comparing patients, whereas some authors have shown better adults. This disease is rare adults, and early were based on comparable small numbers selected Our aim was first perform population‐based study...
Vocal cord palsy occurs in 3-5 per cent of patients after thyroidectomy. To reduce this complication, intraoperative nerve monitoring (IONM) has been introduced, although its use remains controversial. This study investigated the risk postoperative vocal with and without intermittent IONM.Patients registered Scandinavian Quality Register for Thyroid, Parathyroid Adrenal Surgery, 2009-2013, were included. Early recurrent laryngeal was diagnosed within 6 weeks surgery. Permanent defined as...
In individual patients with squamous cell carcinoma of the head and neck (SCCHN), established prognostic factors do not satisfactorily predict clinical outcome. Although karyotype is an independent factor in certain hematologic malignancies solid tumors, no data have been reported concerning possible relationship between chromosomal abnormalities outcome SCCHN:In 116 cases primary SCCHN, short term cultures were analyzed cytogenetically during 1987 through 1991, karyotypes divided into four...
BACKGROUND p27, a cyclin-dependent kinase inhibitor, regulates progression from G1 to S phase. There have been few clinical reports of low p27 expression associated with poor survival among patients cancer; however, there no such an association in cases head and neck cancer. The authors investigated whether oral tongue squamous cell carcinoma was their prognosis. METHODS Ninety-four were analyzed. performed immunohistochemistry on all Western blot analysis 19 available patients. Cox...
Abstract Histopathologic malignancy score and DNA ploidy were investigated as prognostic factors for 72 cases of squamous cell carcinoma the head neck (HNSCC). The grading was based upon four different morphologic characteristics tumor population tumorhost relationship. determined through flow cytometry on fresh‐frozen samples. median 20, with 71% tumors scoring < 20 being diploid 68% ⩾ nondiploid ( p = 0.003). Univariate analysis revealed that had a significantly higher proportion...
Handheld mobile phones were introduced in Denmark and Sweden during the late 1980s. This makes Danish Swedish populations suitable for a study aimed at testing hypothesis that long-term phone use increases risk of parotid gland tumors. In this population-based case-control study, authors identified all cases aged 20-69 years diagnosed with tumor 2000-2002 certain parts Sweden. Controls randomly selected from population base. Detailed information about was collected 60 malignant tumors (85%...
Abstract We report the finding of clonal structural chromosome abnormalities in short‐term cultures from 15 squamous cell carcinomas head and neck region. When distribution chromosomal breakpoints these tumors 16 previously described are assessed, a marked clustering is seen at bands 1p22 11q13, which rearranged eight nine tumors, respectively. No other band was involved aberrations more than five tumors. Cytogenetic evidence gene amplification four three times form homogeneously staining...
Conclusion: This study shows a persistent trend of an increase in the incidence carcinoma tongue into twenty-first century for both sexes and all age groups except young males. Objectives: During last decades increased squamous cell (SCC) adults has been reported. We previously showed SCC Scandinavia 1960–1994, most pronounced patients aged 20–39 years. The aim this was to investigate whether cancer continued population-based Nordic countries. Methods: Data reported SCCs base 20–79 years...
Conclusions. The results of this study confirm that both smoking tobacco and alcohol consumption are risk factors for oral oropharyngeal squamous cell carcinoma (OOSCC). use moist snuff had no effect on the OOSCC, probably due to low levels tobacco-specific N-nitrosamines in Swedish snuff. Objective. aims population-based case-control southern Sweden were establish estimates cigarette evaluate whether is a factor OOSCC. Material methods. Between September 2000 January 2004, 132/165...
Conclusions: The results confirm that tumour stage influences the risk of recurrence/second primary (SPT). High-risk human papillomavirus (HPV)-infected patients have a significantly higher recurrence/SPT compared with high-risk HPV-negative patients. High alcohol consumption was associated recurrence/SPT. In this study, competing death in intercurrent disease (DICD) given special consideration. Objectives: aim present study to evaluate whether any factors which were found increase oral and...
Incidence of human papillomavirus (HPV)-positive head and neck squamous cell carcinoma (HNSCC) is rising in several countries. Intriguingly, large variations HPV16 viral load different proportions the physical status among HNSCC have been reported. We analysed fresh biopsies 275 patients from South Swedish Health Care Region for HPV types with modified general primer PCR Luminex. Seventy-eight HPV16-positive cases were further investigated DNA using quantitative E2 E7 genes. Presence intact...
Fluorescence in situ hybridization (FISH), including COBRA-FISH, was used to characterize 11 salivary gland tumors that had been investigated by banding analysis. Five cases were pleomorphic adenoma (PA), three adenoid cystic carcinoma, and one case each mucoepidermoid carcinoma ex-pleomorphic (CaPA), adenocarcinoma. All selected on the basis they shown rearrangement of 6q or 9p unresolved aberrations after karyotyping. The COBRA-FISH FISH analyses led a revised karyotype all informative...
Abstract Two adenoid cystic carcinomas, one of the nasal cavity, other a bronchial tumor, were cytogenetically analyzed. The former had t(6;9)(q21‐22;p13‐21) as sole karyotypic abnormality. latter two related abnormal clones, resulting in mosaic karyotype 46, XY, t(9;17)(p13;p13)/46, Y, t(X;6)(p22;q23), t(9;17)(p13;p13). profiles cases, only respiratory tract carcinomas that have been characterized, differ little from those previously reported major salivary glands, underscoring fundamental...
Amplification of 11q13 DNA sequences and overexpression CCND1 are common findings in head neck squamous cell carcinoma (HNSCC), identified about 30% the cases. However, little is known initiation amplification organization amplicon. In order to study structure amplicon more detail learn mechanisms involved its initiation, prometaphase, metaphase, anaphase fluorescence situ hybridization (FISH) with 40 BAC clones spanning a 16-Mb region chromosome bands 11q12.2 11q13.5 was performed nine...
The development of alternative treatment regimens in clinical oncology has increased the need for early prediction cancer therapy outcome. aim this study was, phase, to identify patients with advanced head and neck cancer, responding or not initiated therapy. tumour metabolic rate glucose (MRgl) examined by 2-18FDG-PET was determined 17 before after first weeks either radiotherapy (16–35 Gy) one course combination chemotherapy. Metabolic values—uptake values normalized plasma activity...