We established a mouse model of cardiac dysfunction due to myocardial infarction (MI). For this we ligated the left anterior descending coronary artery in male C57BL/6J mice and assessed healing ventricular (LV) remodelling at 1, 2 4 days weeks after MI. Echocardiography was performed 1 2, 6 months found that neutrophil infiltration infarct border noticeable 1-2 days. Marked macrophage occurred day 4, while lymphocyte apparent 7-14 Massive proliferation fibroblasts collagen accumulation...

Internet platforms and self-media have become vital online communities for promoting positive reputations hotels. Previous studies primarily focused on enhancing electronic word-of-mouth (eWOM) through improvements in hotel infrastructure staff services. As hotels deepen their digital transformation, the application of various artificial intelligence technologies service encounters significantly impacts experience. This study explores effects voice assistant (VA) attributes reputation...

Objective— Our preliminary data suggested that angiotensin II (Ang II)–induced reactive oxygen species are involved in intercellular adhesion molecule-1 (ICAM-1) expression and leukocyte infiltration the rat thoracic aorta. Other reports demonstrating species–induced cell growth a potential role of NAD(P)H oxidase vascular hypertrophy. In present study, we postulate is functionally Ang II–induced ICAM-1 expression, macrophage infiltration, growth, inhibition attenuates these processes...

This study aims to explore the relationship between resilience, social support, positive affect and posttraumatic growth among Chinese women with infertility, examine mediating role of affect. A convenience sample 1733 diagnosed infertility was recruited from outpatient clinics at three reproductive hospitals in Shandong Province China May 2015 April 2016. They completed a background questionnaire, Posttraumatic Growth Inventory, Perceived Social Support Questionnaire, Connor-Davidson...

Abstract Background Esophageal strictures significantly impair patient quality of life and present a therapeutic challenge, particularly due to the high recurrence post-ESD/EMR. Current treatments manage symptoms rather than addressing disease's etiology. This review concentrates on mechanisms esophageal stricture formation recurrence, seeking highlight areas for potential intervention. Methods A literature search was conducted through PUBMED using terms: stricture, mucosal resection,...

Inflammation may play an important role in the pathogenesis of cardiac fibrosis heart failure (HF) after myocardial infarction (MI). N -acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) is a naturally occurring antifibrotic peptide whose plasma concentration increased 4- to 5-fold by angiotensin-converting enzyme inhibitors. We tested hypothesis that rats with HF MI, Ac-SDKP acts as anti-inflammatory cytokine, preventing and also reversing noninfarcted area (reactive fibrosis), thus affording...

The beneficial effects of ACE inhibitors (ACEi) or angiotensin II type 1 receptor antagonists (AT -ant) are reportedly mediated by NO in heart failure (HF). We hypothesized that the absence endothelial synthase (eNOS), (1) left ventricular (LV) dysfunction and myocardial remodeling would be more severe after infarction (MI), (2) cardioprotective effect ACEi AT -ant diminished absent mice with HF MI. eNOS knockout (eNOS−/−) wild-type C57BL/6J (C57) (+/+) were subjected to MI ligating coronary...

N -acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) inhibits not only hematopoietic cell proliferation but also fibroblast and collagen synthesis in vitro. Ac-SDKP prevents deposition the left ventricle (LV) rats with renovascular hypertension (renin dependent). However, it is clear whether has similar effects a model of renin-independent (aldosterone-salt). Using hypertensive rat cardiac renal fibrosis created by chronic elevation circulating aldosterone (ALDO) levels, we examined effect on...

Angiotensin II (Ang II) acts mainly on two receptor subtypes: AT 1 and 2 . Most of the known biological actions Ang are mediated by receptors; however, role receptors remains unclear. We tested hypothesis that cardioprotective effects antagonists (AT -ant) after myocardial infarction (MI) partially activation thus in gene knockout mice −/Y), effect -ant will be diminished or absent. MI was induced ligating left anterior descending coronary artery. Four weeks later, −/Y their wild-type...

Serum cytokine profile and T helper (Th)1/Th2 cell balance are related to the success of embryo implantation, although not yet firmly linked recurrent implantation failure (RIF), a repeated achieve clinical pregnancy following multiple high-quality transfer. In this prospective study, comprehensive bioinfomatic analysis logistic regression were used compare serum profiles 41 RIF patients with those 29 subjects first-cycle successful in mid-luteal phase assess alterations at five weeks...

Background Resilience has been identified as a personal construct that may contribute to the process of healthy ageing in older people. To date, no measurement instrument tested evaluate resilience C hinese Aim examine psychometric testing and clinical application version Scale ( RS ) Methods A descriptive cross‐sectional study design was used. Forward backward translation procedures were used obtain semantic equivalence original E nglish . Content validity examined by experts, followed...

Abstract Physical activity has been shown to impact mental health in vitro fertilization-embryo transfer (IVF-ET) patients, but the relationship between domain-specific physical and this population remains unclear. In a cross-sectional observational study, 208 patients undergoing IVF-ET with long-term ovulation induction cycles were recruited from reproductive center. The International Activity Questionnaire symptom checklist 90 (SCL-90) used assess levels status, respectively. Analyses of...

Abstract Aim To evaluate the relationship between physiological and psychological stress on pregnancy outcome in women undergoing vitro fertilization‐embryo transfer (IVF‐ET) treatment. Methods Women first IVF cycle were enrolled to complete Self‐Rating Anxiety Scale (SAS) Depression (SDS). Their blood samples collected 3rd day of menstrual measure 5‐hydroxytryptamine, renin, norepinephrine, angiotensin II cortisol. Salivary amylase was obtained embryo day. Results Compared with normal who...

The objective of this study was to find out which N-terminal segment/s amyloid precursor protein (APP) has any neurotrophic properties, since soluble APP-α (sAPP-α) effects. We investigated properties eight peptide segments APP. APP63-73 able enhance neuronal growth; augment axonal and cell body growth in human neuroblastoma line, SH-SY5Y. Neurotrophic effects chronic treatment were assessed vivo using streptozotocin-induced diabetes ovariectomized rats. Thus, demonstrated that both vitro.

Purpose: Patients with gastrointestinal bleeding (GIB) and acute myocardial infarction (AMI) have higher mortality than that either GIB or AMI alone. The aims of this study were to determine the incidence risk factors in patients GIB. Methods: From January 2015 2018, we retrospectively studied 1287 Renmin Hospital Wuhan University. Various demographic, laboratory outcome data reviewed by charts. Results: Thirty-seven had placed group rest 1250 non-AMI group. more likely be older 70 years,...

Abstract Background Patients with omphalocele, a midline abdominal wall defect at the umbilical cord base, have low survival rate. However, long-term outcomes of fetuses prenatally diagnosed omphalocele scarcely been studied. Therefore, we investigated ultrasonographic features, genetic characteristics, and maternal fetal provided reference for perinatal management such cases. Methods A total 120 pregnant females were using prenatal ultrasonography Fujian Provincial Maternity Child Health...