A5087425871- Psoriasis: Treatment and Pathogenesis
- Wound Healing and Treatments
- Dermatology and Skin Diseases
- Diabetic Foot Ulcer Assessment and Management
- Pneumonia and Respiratory Infections
- Genetic Syndromes and Imprinting
- Acupuncture Treatment Research Studies
- Nail Diseases and Treatments
- Cancer-related gene regulation
- Spondyloarthritis Studies and Treatments
- Periodontal Regeneration and Treatments
- Bacterial Identification and Susceptibility Testing
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Phytoestrogen effects and research
- Cytomegalovirus and herpesvirus research
- Autoimmune and Inflammatory Disorders Research
- Clostridium difficile and Clostridium perfringens research
- Cancer and Skin Lesions
- Retinoids in leukemia and cellular processes
- Sirtuins and Resveratrol in Medicine
- Welding Techniques and Residual Stresses
- Cutaneous lymphoproliferative disorders research
- Pharmacological Effects of Medicinal Plants
- Tendon Structure and Treatment
- Kruppel-like factors research
Yueyang Hospital
2018-2025
Shanghai University of Traditional Chinese Medicine
2018-2025
China-Japan Friendship Hospital
2018-2024
Chengdu University
2022
Cangzhou Central Hospital
2008-2018
Hospital of Hebei Province
2017
Introduction Limited by the specific location of atopic facial dermatitis, treatment options for dermatitis are limited. Our previous research confirms that BiShengZhiYan cream (BSZY cream) can reconstruct damaged skin barrier and strengthen repair ability skin. However, little evidence its efficacy safety is available. Methods analysis A protocol a randomised, double-blind, controlled trial BSZY designed patients with mild-to-moderate dermatitis. We will recruit 130 from Yueyang Hospital...
Sheng-ji Hua-yu(SJHY) formula is one of the most useful Traditional Chinese medicine (TCM) in treatment delayed diabetic wound. However, elucidating related molecular biological mechanism how SJHY Formula affects excessive inflammation process re-epithelialization wound healing a task urgently needed to be fulfilled. The objectives this study evaluate effect antagonisic expression pro-/anti-inflammatory factors on transforming growth factor-β(TGF-β) superfamily (activin and follistatin)...
Chronic ulcer, including diabetic varicose and pressure negatively affects patients' quality of life. As microbiology plays an important role in the mechanism pathology for chronic wound healing, this study concentrates on microecology environment how Traditional Chinese Medicine (TCM) regulates bacteria. Method. The took samples from 35 patients analyzed bacteria variation before after TCM treatment by 16s rRNA sequencing. All were evaluated aspects α-diversity, β-diversity, Simpson's...
Treatment of psoriasis is always difficult, which requires intensive scientific research. Tripterygium wilfordii Hook F (TwHF) with acitretin(TwHF + acitretin) normally used in treating psoriasis. This study aimed to investigate the correlation plasma miR-126 expression risk and severity psoriasis, its predictive value response TwHF acitretin treatment MiRNA-126(MiR-126) was analyzed patients at month 0 (M0), M1, M3 M6 health controls (HCs) enrollment by qPCR. Psoriasis-affected body surface...
The potential toxicity of Chinese herbal medicine has attracted more attention in recent years. Jueyin granules (JYG), a polyherbal formula, have been proven to be an effective agent for treating psoriasis both animal models and clinical research. However, little is known about the possible acute chronic JYG. objective this study was investigate safety JYG ICR mice Wistar rats. To examine JYG, were randomly divided into experimental group control group, each comprising 20 (10 male 10...
Carbapenem pharmacokinetic (PK) profiles are significantly different in critically ill patients because of the drastic variability patients' physiological parameters. Published population PK studies have mainly focused on specific diseases, and majority these had small sample sizes. The aim this study was to develop a model imipenem that estimated influence various clinical biological covariates use extracorporeal membrane oxygenation (ECMO) continuous renal replacement therapy (CRRT). A...
Palmoplantar warts (PWs) are a usual skin disease associated with human papillomavirus (HPV) that can affect patients' quality of life. The traditional Chinese medicine (TCM) Weiren Xiaoyou formula (WRXYF) is relatively gentle and effective therapy has achieved good therapeutic effects in clinical practice, but its mechanism not yet been studied.
ABSTRACT Bergapten (BP) is a plant‐derived furocoumarin that has wide range of pharmacological effects. BP serves as candidate amplifier in phototherapy against skin inflammation, such psoriasis and atopic dermatitis. However, the anti‐inflammatory role remains elusive. We utilized IL‐17A‐stimulated keratinocyte line imiquimod‐challenged BALB/c mice to imitate psoriasis‐like inflammation. Inflammatory phenotypes were determined by expressions inflammatory genes cytokines, histopathological...
BACKGROUND:Recent studies have illustrated that the transcription co-repressor, C-terminal binding protein 1 (CtBP1), links metabolic alterations to controls in proliferation, EMT, genome stability, metabolism, and lifespan, but whether CtBP1 affects cellular redox homeostasis is unexplored. This study was designed investigate mechanism of CtBP1-mediated repression contributes reprogramming. MATERIAL AND METHODS:Knockdown both mouse MEF cells human melanoma changed cell homeostasis. Further,...
Gram-positive bacteria are an important pathogenic factor for bacterial pneumonia. The aim of the present study was to identify differentially expressed genes (DEGs) and explore their associated pathways or expression patterns. Expression profiling gene arrays from two independent datasets, GSE6269 GSE35716, were downloaded Gene Omnibus. DEGs between peripheral blood samples healthy controls patients with pneumonia identified. Functional Annotation Tool in Database Annotation, Visualization...
Psoriasis is a common chronic inflammatory skin disease that prone to recurrence, and the proinflammatory factor, cysteine-rich protein 61 (Cyr61), important in its pathophysiology. Long-term clinical practice has shown Sancao Formula (SC), Chinese herbal compound, effective treatment of psoriasis, but precise mechanism remains unknown. In this study, we investigate by which SC extract alleviates imiquimod (IMQ)-induced psoriasis.The expression Cyr61 psoriatic lesions normal healthy was...
<title>Abstract</title> Objectives To investigate the relationship between ganciclovir trough concentration and its clinical efficacy safety in patients with pulmonary cytomegalovirus (CMV) infection. evaluate target value of therapeutic drug monitoring (TDM) for predicting or toxicity. Methods An observational study was conducted on CMV lung infection Jan 2021 Dec 2023. Target concentrations were collected during TDM outcomes adverse events (AEs) assessed. Multiple regression analyses...
Serum Cardiac troponin Ⅰ (cTn Ⅰ) and lactic acid were measured in 128 neonatal patients with hypoxic-ischemic encephalopathy 38 healthy neonates (control group). cTn levels higher than those (P < 0. 05 ); the differences of these values also statistically significant between serious mild (P<0.05). are two sensitive markers for degree myocardial injury hypoxia encephalopathy. Key words: Hypoxia-ischemia,brain; Troponin Ⅰ; Lactic
Objective To investigate the application and effect of bundle nursing intervention combining with ventilator pipeline disinfection in prevention ventilator-associated pneumonia (VAP) . Methods A total 100 cases who had not received ICU ward, Cangzhou Central Hospital between February 2012 to January 2014 were treated as control group, while another same ward from 2016 observation group. Incidence VAP, length mechanical ventilation time stay two groups compared. Results In...
Abstract Background The Sheng-ji Hua-yu (SJHY) formula is a quite effective Traditional Chinese Medicines (TCM) in the treatment of delayed diabetic wounds. Previous research has shown that SJHY significant anti-inflammatory and wound-healing effects, but precise mechanism remains unknown. purpose this study was to evaluate effects rhein, compound extracted from formula, keratinocytes investigate underlying mechanisms. Methods Microscale thermophoresis (MST) technology used confirm rhein...