A5085905632- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Wound Healing and Treatments
- Cytokine Signaling Pathways and Interactions
- Connective Tissue Growth Factor Research
- Gout, Hyperuricemia, Uric Acid
- Diabetic Foot Ulcer Assessment and Management
- Immunotherapy and Immune Responses
- Medical Research and Treatments
- Bioactive Compounds and Antitumor Agents
- Pressure Ulcer Prevention and Management
- DNA Repair Mechanisms
- Spondyloarthritis Studies and Treatments
- vaccines and immunoinformatics approaches
- Histone Deacetylase Inhibitors Research
- Osteoarthritis Treatment and Mechanisms
- Genomics, phytochemicals, and oxidative stress
- Traditional Chinese Medicine Studies
- Asthma and respiratory diseases
- Ideological and Political Education
- Autoimmune and Inflammatory Disorders
- Flavonoids in Medical Research
- Signaling Pathways in Disease
- Cancer, Hypoxia, and Metabolism
- Cancer, Stress, Anesthesia, and Immune Response
Shanghai University of Traditional Chinese Medicine
2010-2024
Yueyang Hospital
2010-2023
Shanghai University
2020
Institute of Dermatology
2020
University of Pennsylvania
2018-2019
Cancer/testis antigens have emerged as attractive targets for cancer immunotherapy. Clinical studies targeted MAGE-A3, a prototype antigen that is member of the MAGE-A family antigens, in melanoma and lung carcinoma. However, these not yet had significant impact due to poor CD8+ T-cell immunogenicity, platform toxicity, or perhaps limited target availability. In this study, we develop an improved immunogen with cross-reactivity multiple members.In analyzed expression The Cancer Genome Atlas...
Psoriasis is an autoimmune disease mediated by T cells. However, treatment remains a clinical challenge because of its frequent recurrence. Celastrol (Cel), the main active ingredient in Tripterygium wilfordii Hook F, efficacious treating diseases such as psoriasis.To investigate effect and mechanism topical Cel imiquimod (IMQ)-induced psoriasis-like inflammation mice.Female C57BL/6 Langerin-diphtheria toxin receptor (DTR) mice were divided into Vehicle group gel groups. IMQ was used induce...
Objective . Gouty arthritis (GA) is a noninfectious inflammatory disease characterized by self‐limited and severe pain. Huzhang Tongfeng granule one of the most effective traditional Chinese medicines in treatment acute GA. However, its effects on factors process gout inflammation remain unknown. In present study, we aimed to evaluate effect expressions Cyr61 related both experimental models vivo vitro. Methods was provided pharmaceutical preparation room Yueyang Hospital Integrated...
Prolyl hydroxylase domain protein 2 (PHD2) is a well-known master oxygen sensor. However, the role of PHD2 in tumor initiation remains controversial. We find that during transition human nevi to melanoma, expression significantly decreased and lower melanoma associated with worse clinical outcome. Knockdown leads elevated Akt phosphorylation melanocytes. Mice conditional melanocyte-specific Phd2lox/lox (Tyr::CreER;Phd2lox/lox) fail develop pigmented lesions. deletion Phd2 combination...
Perifolliculitis capitis abscedens et suffodiens (PCAS), also known as dissecting cellulitis of the scalp (DCS), is a part "follicular occlusion tetrad" that includes acne conglobate (AC), hidradenitis suppurativa (HS), and pilonidal sinus, which share same pathogenic mechanism, such follicular occlusions, ruptures, infections.A 15-year-old boy had multiple rashes on accompanied by pain.The patient was diagnosed with PCAS or DCS based clinical manifestations laboratory examinations.The...
Cyr61 is considered a novel proinflammatory factor. Gouty arthritis (GA) self-limited inflammatory reaction caused by monosodium urate (MSU) crystals. In this study, we assessed the role of in process GA.We investigated expression MSU-induced rat gout models and MSU-stimulated fibroblast-like synovial (FLS) cells. After inhibiting Cyr61, levels IL-1β, TNF-α, IL-6 were detected ELISA, qPCR, western blot, immunohistochemical methods. We probed downstream NF-κB signaling pathway using inhibitor...
Psoriasis is an incurable, chronic skin disorder with considerable impact on the quality of life. No drugs are available for treating disease. Clarifying progression, exploring risk factors affecting and finding effective treatments few side-effects low recurrence rates critical. This protocol describes a future study that will analyze psoriasis vulgaris progression trends, establish multicenter clinical registration platform, evaluate evidence Chinese Medicine (CM) intervention psoriasis,...
Objective To explore the distribution law of traditional Chinese medicine (TCM) syndrome types in patients with psoriasis vulgaris complicated by metabolic disorders based on same pathogenic factors as blood-heat and blood-stasis pathogenesis to further analyze correlation between adiponectin law.Methods From 1 January 2018 31 December 2019, diagnosed inpatient or outpatient department Dermatology Ward Shanghai Yueyang Hospital normal participants who underwent physical examination center...
Clinical comprehensive decision-making of diabetic ulcers includes curative effect evaluation and prediction. Nevertheless, there are few studies on the prediction ulcers.Set pair analysis (SPA) was used to assess evaluation, therapeutic evaluated by connection degree (CD). The higher-order Markov chain-SPA model established predict future development. predicted results with traditional first-order Markov-SPA were compared actual patients verify effectiveness prediction.The index levels I II...
Quyu Shengji Formula (QSF), a Chinese medicine formula widely used in the clinic, has proven therapeutic effects on diabetic ulcers. Nevertheless, potential mechanism of how QSF cures ulcer remains elusive.To assess against wound healing defects diabetes.Db/db mice were adopted to determine QSF. Further histology analysis was performed by hematoxylin and eosin (H&E) staining. Moreover, expression patterns prostaglandin transporter (PGT), E2 (PGE2), angiogenesis factor vascular endothelial...
Abstract Ultraviolet B (UVB) exposure is a core factor that leads to skin disease or carcinogenesis through the insufficient repair of DNA lesions. UVB‐induced lesions are mainly removed by nucleotide excision (NER) mechanism. The expression histone deacetylase 4 (HDAC4) altered in upon UVB exposure, indicating its possible implication repair. Here, we investigated role HDAC4 NER removal main classes consisting cyclobutane pyrimidine dimers and (6‐4) pyrimidone photoproducts (6‐4PPs). We...
Psoriasis is a common chronic inflammatory skin disease that prone to recurrence, and the proinflammatory factor, cysteine-rich protein 61 (Cyr61), important in its pathophysiology. Long-term clinical practice has shown Sancao Formula (SC), Chinese herbal compound, effective treatment of psoriasis, but precise mechanism remains unknown. In this study, we investigate by which SC extract alleviates imiquimod (IMQ)-induced psoriasis.The expression Cyr61 psoriatic lesions normal healthy was...
Psoriasis is a common chronic inflammatory skin disorder. Qingxiong ointment (QX) natural medicinal combination frequently employed in clinical treatment of psoriasis. However, the active ingredients QX and its precise mechanisms improving psoriasis remain unclear. This study elucidated effects on an Imiquimod (IMQ)-induced mouse model while also exploring regulation ingredient QX, shikonin, HIF-1 signaling pathway HaCaT cells.