A5018238306- Kruppel-like factors research
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Genetic Syndromes and Imprinting
- Cancer-related Molecular Pathways
- Psoriasis: Treatment and Pathogenesis
- Wound Healing and Treatments
- Dermatology and Skin Diseases
- Cell death mechanisms and regulation
- Cancer therapeutics and mechanisms
- Signaling Pathways in Disease
- DNA Repair Mechanisms
- Mitochondrial Function and Pathology
- Ovarian cancer diagnosis and treatment
- Synthesis and bioactivity of alkaloids
- Intracerebral and Subarachnoid Hemorrhage Research
- Sirtuins and Resveratrol in Medicine
- Immunotherapy and Immune Responses
- Cancer Mechanisms and Therapy
- Natural product bioactivities and synthesis
- Heat shock proteins research
- Total Knee Arthroplasty Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Alzheimer's disease research and treatments
- Acute Myeloid Leukemia Research
Chengdu University
2018-2025
First Affiliated Hospital Zhejiang University
2021-2024
Hengyang Normal University
2022-2023
Yueyang Hospital
2022
Shanghai University of Traditional Chinese Medicine
2022
Canada's Michael Smith Genome Sciences Centre
2020-2022
Changhai Hospital
2019-2022
Chongqing Academy of Animal Science
2016-2022
Second Military Medical University
2019-2022
Nanjing University of Finance and Economics
2020-2021
Significance Oxidative stress is an important contributor to aging-associated diseases including cancer and neurodegeneration, antioxidant responses are critical limit manifestations of these diseases. We report that the tumor suppressor Homologous E6-AP Carboxyl Terminus domain Ankyrin repeat containing E3 ubiquitin–protein ligase 1 (HACE1) promotes activity transcription factor, nuclear factor erythroid 2-related 2 (NRF2), a master regulator antioxidative response. In Huntington disease...
Caspase cleavage of huntingtin (htt) and nuclear htt accumulation represent early neuropathological changes in brains patients with Huntington's disease (HD). However, the relationship between caspase activation patterns pathogenesis HD remains poorly understood. The lack a phenotype YAC mice expressing caspase-6-resistant (C6R) mutant (mhtt) highlights proteolysis at 586 aa caspase-6 (casp6) site as key mechanism pathology HD. goal this study was to investigate how residue plays role...
DNA double-strand breaks (DSBs) are traditionally associated with cancer through their abilities to cause chromosomal instabilities or gene mutations. Here we report a new class of self-inflicted DSBs that can drive tumor growth irrespective effects on genomic stability. We discover mechanism which cells in own genome spontaneously independent reactive oxygen species replication stress. In this mechanism, low-level cytochrome c leakage from the mitochondria leads sublethal activation...
Abstract RhoA, a member of the Rho GTPase family, has been extensively studied in regulation cytoskeletal dynamics, gene transcription, cell cycle progression, and transformation. Overexpression RhoA is found many malignancies elevated activity associated with proliferation phenotypes cancer cells. We reported previously that was hyperactivated gastric tissues suppression could partially reverse phenotype cells, but underlying mechanism yet to be elucidated. It activation crucial for G1-S...
Apoptosis, or programmed cell death, is a cellular pathway involved in normal turnover, developmental tissue remodeling, embryonic development, homeostasis maintenance and chemical-induced death. Caspases are family of intracellular proteases that play key role apoptosis. Aberrant activation caspases has been implicated human diseases. In particular, numerous findings implicate Caspase-6 (Casp6) neurodegenerative diseases, including Alzheimer disease (AD) Huntington (HD), highlighting the...
Carboxyl-terminal binding protein 1 (CtBP1) is a transcriptional co-repressor that represses expression of various tumor suppressor genes.In the present study, we identified miR-137 as potential regulator CtBP1 in melanoma cells.Expression cell lines was found to inversely correlate with levels.Target Scan predicted putative site for within 3′ untranslated region (3′UTR) at nt 710-716, which highly conserved across species.To explore mechanism targeting CtBP1, performed an Argonaute 2...
Differential privacy (DP) has been widely explored in academia recently but less so industry possibly due to its strong guarantee. This paper makes the first attempt implement three basic DP architectures deployed telecommunication (telco) big data platform for mining applications. We find that all have than 5% loss of prediction accuracy when weak guarantee is adopted (e.g., budget parameter ε ≥ 3). However, assumed ≤ 0:1), lead 15% ~ 30% loss, which implies real-word industrial systems...
Ovarian cancer (OC) is the leading cause of death among women with gynecologic malignancies. Recent studies have highlighted role Pim1, which belongs to a group constitutively activated serine/threonine kinases, in development. However, effect Pim1 OC largely unclear.OC cell lines overexpression or knockdown were constructed len-tivirus transduction. Cell Counting Kit-8, colony formation, glycolysis stress test and vivo mice models carried out assess on biological functions....
Triptolide is an active component from a Chinese herb, Tripterygium wilfordii which has been applied for treating immune‐related diseases over centuries. Recently, it was reported that variety of cancer cell lines could be sensitized to DNA‐damage based chemotherapy drugs in combination with treatment. In the present study, we show short time exposure (3 h) Triptolide, did not trigger apoptosis, specifically increase breast cells sensitivity Doxorubicin rather than other including...
Abstract Carboxyl‐terminal binding protein 1 (CtBP1) is a transcriptional co‐repressor with oncogenic potential. Immunohistochemistry staining using human breast cancer tissue arrays revealed that 92% of invasive ductal cases have CtBP1‐positive compared to 4% in normal tissue. To explore the functional impact CtBP1 cancer, we examined CtBP1's regulation known tumor suppressors, susceptibility gene (Brca1), and E‐cadherin. We found was recruited promoter regions Brca1 E‐cadherin genes cells....
Activation of caspase-6 in the striatum both presymptomatic and affected persons with Huntington's disease (HD) is an early event pathogenesis. However, little known about role outside central nervous system (CNS) whether caspase activation might play a peripheral phenotypes, such as muscle wasting observed HD. We assessed skeletal tissue from HD patients well-characterized mouse models Cleavage specific substrate lamin A significantly increased obtained well tissues two different models....
Sheng-ji Hua-yu(SJHY) formula is one of the most useful Traditional Chinese medicine (TCM) in treatment delayed diabetic wound. However, elucidating related molecular biological mechanism how SJHY Formula affects excessive inflammation process re-epithelialization wound healing a task urgently needed to be fulfilled. The objectives this study evaluate effect antagonisic expression pro-/anti-inflammatory factors on transforming growth factor-β(TGF-β) superfamily (activin and follistatin)...
Perioperative neurocognitive disorders are common in elderly patients who have undergone surgical procedures. Neuroinflammation induced by microglial activation is a hallmark of these neurological disorders. Acetate can suppress inflammation the context inflammatory diseases. We employed an exploratory laparotomy model with isoflurane anesthesia to study effects acetate on perioperative aged mice. Neurocognitive function was assessed open-field tests and Morris water maze 3 or 7 days...