A5008113112- Immune Cell Function and Interaction
- Long-Term Effects of COVID-19
- Multiple Myeloma Research and Treatments
- COVID-19 Clinical Research Studies
- Immune cells in cancer
- Acute Myeloid Leukemia Research
- Mass Spectrometry Techniques and Applications
- Alzheimer's disease research and treatments
- Endoplasmic Reticulum Stress and Disease
- Biotin and Related Studies
- Hematological disorders and diagnostics
- Viral-associated cancers and disorders
- COVID-19 Impact on Reproduction
- Plant Pathogenic Bacteria Studies
- Complement system in diseases
- Sepsis Diagnosis and Treatment
- Extracellular vesicles in disease
- S100 Proteins and Annexins
- Lymphoma Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Terrorism, Counterterrorism, and Political Violence
- RNA Interference and Gene Delivery
- Phagocytosis and Immune Regulation
- Parasites and Host Interactions
- Pharmacological Receptor Mechanisms and Effects
National Institute of Allergy and Infectious Diseases
2024
National Institutes of Health
2024
Institute of Accelerating Systems and Applications
2023-2024
Cornell University
2023
Canada's Michael Smith Genome Sciences Centre
2018-2022
Medical Research Council
2021
University of Dundee
2021
Division of Undergraduate Education
2021
National Park Service
2020
Istituto Nazionale di Fisica Nucleare, Sezione di Milano
2018
Allergic diseases are common, affecting more than 20% of the population. Genetic variants in TGFβ pathway strongly associated with atopy. To interrogate mechanisms underlying this association, we examined patients and mice Loeys-Dietz syndrome (LDS) who harbor missense mutations kinase domain TGFΒR1/2 . We demonstrate that LDS lead to reduced signaling elevated total allergen-specific IgE, despite presence wild-type T regulatory cells a chimera model. Germinal center activity was enhanced...
Disease modifying treatments for Alzheimer's disease (AD) constitute a major goal in medicine. Current trends suggest that biomarkers reflective of AD neuropathology and modifiable by treatment would provide supportive evidence modification. Nevertheless, lack quantitative tools to assess effects remains hurdle. Cerebrospinal fluid (CSF) biochemical markers such as total tau, p-tau Ab42 are well established AD; however, global changes CSF progression remain largely uncharacterized. Here we...
Inflammation is associated with bone marrow failure syndromes, but how specific molecules impact the microenvironment not well elucidated. We report a novel role for miR-145 target, Toll/interleukin-1 receptor domain containing adaptor protein (TIRAP), in driving failure. show that TIRAP overexpressed various types of myelodysplastic syndromes (MDS) and suppresses all three major hematopoietic lineages. expression promotes up-regulation Ifnγ, leading to myelosuppression through...
Chemical modification of siRNA is achieved in a high-throughput manner (96-well plate format) by copper catalyzed azide-alkyne cycloadditions. This transformation can be performed one synthetic operation at up to four positions with complete specificity, good yield, and acceptable purity. As demonstrated here, this approach extends the current options for oligonucleotide modifications simultaneously facilitates systematic, rapid biological evaluation modified siRNA.
Understanding the molecular functions of less-studied proteins is an important task life science research. Despite reports BZW2 (Basic leucine zipper and W2 domain-containing protein 2) promoting cancer progression first emerging in 2017, little known about its function. Using a quantitative proteomic approach to identify interacting proteins, we found that interacts with both endoplasmic reticulum (ER) mitochondrial proteins. We thus hypothesized localizes promotes formation...
High Resolution Differential Mass Spectrometry (dMS) is an open discovery platform that has the ability to identify and detect quantitative peptide changes in complex mixtures such as CSF without need for antibody reagents. Three important elements of high resolution dMS approach biomarker research include speed, relevance biology, a clear translation path clinical evaluation. Here, we describe use micro-capillary LC coupled with mass spectrometry (MS) markers can distinguish pathologically...
Abstract Activation of inflammatory pathways is associated with bone marrow failure syndromes, but how specific molecules impact on the microenvironment not well elucidated. We report a novel role for miR-145 target, Toll/Interleukin-1 receptor domain containing adaptor protein (TIRAP), in driving failure. show that TIRAP overexpressed various types myelodysplastic syndromes (MDS), and suppresses all three major hematopoietic lineages.. Constitutive expression stem/progenitor cells (HSPC)...