William Z. Potter
A5069167318- Treatment of Major Depression
- Functional Brain Connectivity Studies
- Neurotransmitter Receptor Influence on Behavior
- Tryptophan and brain disorders
- Bipolar Disorder and Treatment
- Neuroscience and Neuropharmacology Research
- Mental Health Research Topics
- Electroconvulsive Therapy Studies
- Schizophrenia research and treatment
- Receptor Mechanisms and Signaling
- Stress Responses and Cortisol
- Bioinformatics and Genomic Networks
- Drug-Induced Hepatotoxicity and Protection
- Attention Deficit Hyperactivity Disorder
- Pharmacogenetics and Drug Metabolism
- Neuroendocrine regulation and behavior
- Dementia and Cognitive Impairment Research
- Genetic Associations and Epidemiology
- Genetics and Neurodevelopmental Disorders
- Health Systems, Economic Evaluations, Quality of Life
- Autism Spectrum Disorder Research
- Computational Drug Discovery Methods
- Pharmacological Receptor Mechanisms and Effects
- Neural and Behavioral Psychology Studies
- Health, Environment, Cognitive Aging
National Institute of Mental Health
1996-2023
Alkermes (Ireland)
2022
National Institutes of Health
1988-2021
Seminole State College Oklahoma
2018
AstraZeneca (United States)
2016
National Institute of Mental Health
1988-2015
Merck & Co., Inc., Rahway, NJ, USA (United States)
2007-2015
Foundation for the National Institutes of Health
2011-2014
United States Military Academy
2010
Merck (Japan)
2008
Recent studies of acetaminophen‐induced liver damage in animals indicate that acetaminophen is converted the to a chemically reactive arylating agent normally detoxified by conjugation with glutathione. When dose large enough deplete hepatic glutathione, however, there extensive arylation macromolecules and cell death. This paper presents evidence administration glutathione‐like nucleophiles, such as cysteamine, protects mice from macromolecules, necrosis, death caused metabolite. Additional...
Objective: There are significant unmet needs in the treatment of schizophrenia, especially for cognitive impairment, negative syndrome, and function. Preclinical data suggest that agonists with selective affinity acetylcholine muscarinic receptors provide a potentially new mechanism to treat schizophrenia. The authors studied xanomeline, relatively type 1 4 (M M ) receptor agonist, determine if this agent is effective Method: In pilot study, examined efficacy xanomeline on clinical outcomes...
• Cerebrospinal fluid levels of 5-hydroxyindoleacetic acid, a metabolite serotonin, were measured in relation to aggression, impulsivity, and social functioning 29 children adolescents with disruptive behavior disorders. The cerebrospinal acid level was low compared that age-, sex-, race-matched patients obsessive-compulsive disorder. Within the group, significant negative correlations age-corrected seen for child's report aggression toward people expressed emotionality child his or her...
We previously postulated that acetaminophen-induced hepatic necrosis in mice results from the formation of a reactive metabolite arylates vital cellular macro-molecules. While studying species differences susceptibility to necrosis, hamsters were found be particularly vulnerable. now report relationships between glutathione depletion, arylation macromolecules vivo and vitro after administration acetaminophen hamsters.
Approximately 10% to 20% of isoniazid recipients manifest biochemical evidence liver injury. A smaller number patients develop clinically overt hepatitis. Isoniazid is metabolized in man at extremely variable rates, and the rate under genetic control. Two separate clinical studies have noted a possible relation between susceptibility injury rapid metabolism (acetylation) drug. For this reason, 21 who had recovered from probable hepatitis 5 previously manifested mild were genetically...
The gap between chronological age (CA) and biological brain age, as estimated from magnetic resonance images (MRIs), reflects how individual patterns of neuroanatomic aging deviate their typical trajectories. MRI-derived (BA) estimates are often obtained using deep learning models that may perform relatively poorly on new data or lack interpretability. This study introduces a convolutional neural network (CNN) to estimate BA after training the MRIs 4,681 cognitively normal (CN) participants...
Article AbstractBackground: Atomoxetine is a nonstimulant drug being studied for the treatment of attention-deficit/hyperactivity disorder (ADHD). highly specific inhibitor presynaptic norepinephrine transporter with minimal affinity other noradrenergic receptors or neurotransmitter transporters receptors. Results 2 proof-of-concept studies are reported that tested hypothesis selective uptake would be effective ADHD in school-aged children. Method: Two identical 12-week, stratified,...
Regions of the temporal and parietal lobes are particularly damaged in Alzheimer's disease (AD), this leads to a predictable pattern brain atrophy. In vivo quantification subregional atrophy, such as changes cortical thickness or structure volume, could lead improved diagnosis better assessment neuroprotective effects therapy. Toward end, we have developed fast robust method for accurately quantifying cerebral structural several subcortical regions using serial MRI scans. 169 healthy...
Despite strong theoretical rationale and preclinical evidence, several glutamate-targeted treatments for schizophrenia have failed in recent pivotal trials, prompting questions as to target validity, compound inadequacy, or lack of engagement. A key limitation glutamate-based treatment development is the functional target-engagement biomarkers translation between early-stage clinical studies. We evaluated utility 3 potential biomarkers-ketamine-evoked changes magnetic imaging (fMRI) blood...
Abstract Background The polygenic nature of Alzheimer’s disease (AD) suggests that multiple variants jointly contribute to susceptibility. As an individual’s genetic are constant throughout life, evaluating the combined effects disease-associated risks enables reliable AD risk prediction. Because complexity genomic data, current statistical analyses cannot comprehensively capture AD, resulting in unsatisfactory However, deep learning methods, which nonlinearity within high-dimensional may...
Cerebrospinal fluid hormones, monoaminergic metabolites, and dynorphin A (1-8 sequence) were examined in 43 children with severe, primary obsessive-compulsive disorder. levels of 5-hydroxyindoleacetic acid positively correlated one eight disorder severity ratings three seven measures improvement following 5 weeks treatment clomipramine hydrochloride. Arginine vasopressin concentration was significantly negatively several symptom severity, while oxytocin depressive symptoms. The ratio...
We studied the steady-state pharmacokinetics of bupropion hydrochloride, a unicyclic aminoketone antidepressant, in depressed patients. The metabolites hydroxybupropion (HB), threohydrobupropion, and erythrohydrobupropion predominated over parent compound plasma cerebrospinal fluid at steady state. Plasma concentrations each metabolite correlated with concentrations. Higher were associated poor clinical outcome. This relationship was most striking HB; HB levels greater than 1250 ng/mL all...
Loss-of-function mutations in the genes associated with primary microcephaly (MCPH) reduce human brain size by about two-thirds, without producing gross abnormalities organization or physiology and leaving other organs largely unaffected [Woods CG, et al. (2005) Am J Hum Genet 76:717-728]. There is also evidence suggesting that MCPH have evolved rapidly primates humans been subjected to selection recent evolution [Vallender EJ, (2008) Trends Neurosci 31:637-644]. Here, we show common...
Abstract With increasing numbers of people with Alzheimer's and other dementias across the globe, many countries have developed national plans to deal resulting challenges. In United States, National Project Act, signed into law in 2011, required creation such a plan annual updates thereafter. Pursuant this, US Department Health Human Services (HHS) released Plan Address Disease 2012, including an ambitious research goal preventing effectively treating disease by 2025. To guide investments,...