A5002154844- Dementia and Cognitive Impairment Research
- Health, Environment, Cognitive Aging
- Dental Health and Care Utilization
- Health disparities and outcomes
- Alzheimer's disease research and treatments
- Nutritional Studies and Diet
- Oral microbiology and periodontitis research
- Frailty in Older Adults
- Attention Deficit Hyperactivity Disorder
- Diet and metabolism studies
- Health Systems, Economic Evaluations, Quality of Life
- Birth, Development, and Health
- Traumatic Brain Injury Research
- Aging and Gerontology Research
- Blood Pressure and Hypertension Studies
- Genetic Associations and Epidemiology
- Stroke Rehabilitation and Recovery
- Traumatic Brain Injury and Neurovascular Disturbances
- Aging, Elder Care, and Social Issues
- Cognitive Abilities and Testing
- Geriatric Care and Nursing Homes
- Patient-Provider Communication in Healthcare
- Intergenerational Family Dynamics and Caregiving
- Ethics in Clinical Research
- Pesticide Exposure and Toxicity
Duke University
2016-2025
Duke University Hospital
2014-2025
Duke Medical Center
2015-2025
San Francisco VA Medical Center
2020-2023
University of California, San Francisco
2020-2023
Institute of Behavioral Sciences
2010-2023
UNC Lineberger Comprehensive Cancer Center
2020
University of North Carolina at Chapel Hill
2016-2020
Neurology, Inc
2020
Columbia University
2020
To estimate the prevalence of Alzheimer's disease (AD) and other dementias in USA using a nationally representative sample.The Aging, Demographics, Memory Study sample was composed 856 individuals aged 71 years older from Health Retirement (HRS) who were evaluated for dementia comprehensive in-home assessment. An expert consensus panel used this information to assign diagnosis normal cognition, cognitive impairment but not demented, or (and subtype). Using sampling weights derived HRS, we...
Background: Cognitive impairment without dementia is associated with increased risk for disability, health care costs, and progression to dementia. There are no population-based prevalence estimates of this condition in the United States. Objective: To estimate cognitive States determine longitudinal mortality outcomes. Design: Longitudinal study from July 2001 March 2005. Setting: In-home assessment impairment. Participants: Participants ADAMS (Aging, Demographics, Memory Study) who were...
<b><i>Background:</i></b> The association between antecedent head injury and AD is inconsistent. <b><i>Objective:</i></b> To examine the early adult injury, as documented by military hospital records, dementia in late life; to evaluate interaction <i>APOE</i> ε4 risk factors for dementia. <b><i>Methods:</i></b> study had a population-based prospective historical cohort design. It included men who were World War II Navy Marine veterans, hospitalized during their service with diagnosis of...
We conducted a co-twin control study among 50 elderly twin pairs with onsets of Alzheimer9s disease (AD) separated by 3 or more years. Twenty-three male (46%) were screened from the (U.S.) National Academy Sciences-National Research Council Registry (NAS-NRC Registry) World War II veteran twins; others (mostly women) had responded to advertisements referred AD clinics. Twenty-six (52%) monozygous. The onset was inversely associated prior use corticosteroids ACTH (odds ratio [OR], 0.25; 95%...
Previous estimates of the prevalence geriatric depression have varied. There are few large population-based studies; most these focused on individuals younger than 80 years. No US studies been published since advent newer antidepressant agents.In 1995 through 1996, as part a population study, we examined current and lifetime depressive disorders in 4,559 nondemented aged 65 to 100 This sample represented 90% elderly Cache County, Utah. Using modified version Diagnostic Interview Schedule,...
<b><i>Objective:</i></b> To examine the prevalence of Alzheimer's disease (AD) and other dementias in relation to age, education, sex, genotype at <i>APOE</i>. Recent studies suggest age heterogeneity risk AD associated with <i>APOE</i> a possible interaction between <i>APOE</i>-ε4 female sex as factors. We studied these topics 5,677 elderly residents Cache County, Utah, population known for long life expectancy high participation rates. <b><i>Methods:</i></b> screened dementia brief...
<i>Objective:</i> We describe the design and methods of Aging, Demographics, Memory Study (ADAMS), a new national study that will provide data on antecedents, prevalence, outcomes, costs dementia ‘cognitive impairment, not demented’ (CIND) using unique based nationally representative Health Retirement (HRS). also illustrate potential uses ADAMS information to interested researchers obtaining HRS data. <i>Methods:</i> The is first population-based in United States...
Several methods of estimating prevalence dementia are presented in this article. For both Brookmeyer and the Chicago Health Aging project (CHAP), estimates derived statistically, forward calculating from incidence survival figures. The choice rates on which to build may be critical. used several published studies, whereas CHAP investigators applied observed their own cohort. Aging, Demographics, Memory Study (ADAMS) East Boston Senior Project (EBSHP) were sample surveys designed ascertain...
Our study estimates the sensitivity and specificity of Medicare claims to identify clinically-diagnosed dementia, documents how errors in dementia assessment affect cost estimates. We compared from 1993-2005 clinical assessments carried out 2001-2003 for Aging Demographics Memory Study (ADAMS) cohort (n = 758) Health Retirement Study. The was 0.85 0.89 (0.64 0.95 AD). Persons with program (in 2003) $7,135 more than controls (P < 0.001) when using $5,684 ADAMS 0.001). Using results a 110%...
Background: Previous studies have attempted to provide estimates of depression prevalence in older adults. The Aging, Demographics and Memory Study (ADAMS) is a population-representative study that included assessment, providing an opportunity estimate the late life U.S.A.Methods: ADAMS sample was drawn from larger Health Retirement Study. A total 851 856 participants aged 71 had available data. Depression measured using Composite International Diagnostic Interview – Short Form (CIDI-SF)...
Observational studies suggest reduced risk of Alzheimer disease (AD) in users hormone therapy (HT), but trials show higher risk. We examined whether the association HT with AD varies timing or type use.Between 1995 and 2006, population-based Cache County Study followed 1,768 women who had provided a detailed history on age at menopause use HT. During this interval, 176 developed incident AD. Cox proportional hazard models evaluated AD, overall relation to timing, duration use, (opposed vs...
Estimates of incident dementia, and cognitive impairment, not dementia (CIND) (or the related mild impairment) are important for public health clinical care policy. In this paper, we report US national incidence rates CIND.Participants in Aging, Demographic, Memory Study (ADAMS) were evaluated impairment using a comprehensive in-home assessment. A total 456 individuals aged 72 years older, who demented at baseline, followed longitudinally from August 2001 to December 2009. An expert...
Increasing evidence suggests Alzheimer's disease (AD) pathophysiology is influenced by primary and secondary bile acids, the end product of cholesterol metabolism. We analyze 2,114 post-mortem brain transcriptomes identify genes in alternative acid synthesis pathway to be expressed brain. A targeted metabolomic analysis acids measured from samples 111 individuals supports these results. Our metabolic network that taurine transport, synthesis, metabolism differ AD cognitively normal...
Depressive symptoms are common and can be debilitating in the months after head injury. Head injury also have long-term cognitive effects, but little is known about risk of depression associated with We investigated lifetime rates depressive illness 50 years closed injury.Participants were male World War II veterans who served during 1944-1945 hospitalized at that time for a injury, pneumonia, or laceration, puncture, incision wounds. used military medical records to establish presence...
OBJECTIVES: To estimate the prevalence of neuropsychiatric symptoms and examine their association with functional limitations. DESIGN: Cross‐sectional analysis. SETTING: The Aging, Demographics, Memory Study (ADAMS). PARTICIPANTS: A sample adults aged 71 older (N=856) drawn from Health Retirement (HRS), a nationally representative cohort U.S. 51 older. MEASUREMENTS: presence (delusions, hallucinations, agitation, depression, apathy, elation, anxiety, disinhibition, irritation, aberrant motor...
Background The diagnosis of cognitive impairment and dementia must reflect an increasingly diverse aging United States population. This study compared direct testing informant reports cognition with clinical diagnoses between African Americans whites. Methods Participants in the Aging, Demographics, Memory Study completed in‐person evaluations, were assigned (by a consensus panel experts) normal; impairment, not demented (CIND); dementia. Consortium to Establish Registry for Alzheimer's...
Zandi, Peter P.; Carlson, Michelle C.; Plassman, Brenda L.; Welch-Bohmer, Kathleen A.; Mayer, Lawrence S.; Steffens, David Breitner, John C. S. for the Cache County Memory Study Investigators
We evaluated the relation of education and intelligence in early adult life to cognitive function a group elderly male twins. The Army General Classification Test (AGCT) was administered US armed forces inductees 1940s. Fifty years later, as part study dementia twins, we tested status 930 these men using modified Telephone Interview for Cognitive Status (TICS-m). TICS-m scores obtained later were correlated with AGCT (r = 0.457) 0.408). Thus, univariate analyses, score accounted 20.6% 16.7%...
OBJECTIVES:To examine the association between neuropsychiatric symptoms and risk of institutionalization death.DESIGN: Analysis longitudinal data.SETTING: The Aging, Demographics, Memory Study (ADAMS).PARTICIPANTS: Five hundred thirty-seven adults aged 71 older with cognitive impairment drawn from Health Retirement (HRS).MEASUREMENTS: Neuropsychiatric (delusions, hallucinations, agitation, depression, apathy, elation, anxiety, disinhibition, irritation, aberrant motor behaviors) caregiver...
Background This was a prospective study of dementia to elucidate mechanisms disease risk factors amenable modification and specifically determine whether midlife cognitive physical leisure activities are associated with delayed onset or reduced within older male twin pairs. Methods The co‐twin control design used prospectively collected exposure information predict 20 40 years later. subjects were community‐dwelling nursing home residents living throughout the continental United States. We...