A5074474145- Schizophrenia research and treatment
- Functional Brain Connectivity Studies
- Mental Health and Psychiatry
- Tryptophan and brain disorders
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Bipolar Disorder and Treatment
- Treatment of Major Depression
- Advanced Neuroimaging Techniques and Applications
- Mental Health Research Topics
- Mental Health Treatment and Access
- Autism Spectrum Disorder Research
- Obsessive-Compulsive Spectrum Disorders
- Psychosomatic Disorders and Their Treatments
- Advanced MRI Techniques and Applications
- Gun Ownership and Violence Research
- Child and Adolescent Psychosocial and Emotional Development
- Electroconvulsive Therapy Studies
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Suicide and Self-Harm Studies
- Genetics and Neurodevelopmental Disorders
- Attention Deficit Hyperactivity Disorder
- Cannabis and Cannabinoid Research
- Neural dynamics and brain function
Columbia University
2015-2024
New York State Psychiatric Institute
2015-2024
New York Psychoanalytic Society and Institute
2015-2024
Columbia University Irving Medical Center
2015-2024
Research Foundation For Mental Hygiene
2018
NewYork–Presbyterian Hospital
2016-2017
University of Toronto
2017
New York College of Health Professions
2017
Ludwig-Maximilians-Universität München
2017
Nathan Kline Institute for Psychiatric Research
2017
<h3>Importance</h3> Multiple lines of evidence suggest a deficit in dopamine release the prefrontal cortex (PFC) schizophrenia. Despite prevalence concept cortical hypodopaminergia schizophrenia, vivo imaging PFC has not been possible until now, when validity using positron emission tomographic D2/3 radiotracer carbon 11–labeled FLB457 combination with amphetamine paradigm was clearly established. <h3>Objectives</h3> To (1) test amphetamine-induced dorsolateral (DLPFC) drug-free or...
Postmortem studies have found evidence of γ-aminobutyric acid (GABA) deficits in fast-spiking, parvalbumin-positive interneurons the prefrontal cortex schizophrenia. Magnetic resonance spectroscopy unmedicated patients reported glutamine or glutamate-glutamine (Glx) elevations this region. Abnormalities these transmitters are thought to play a role cognitive impairments illness.To measure GABA and Glx levels vivo 2 brain regions medicated with schizophrenia healthy controls.Case-control...
Significance Neuromelanin-sensitive MRI (NM-MRI) purports to detect the content of neuromelanin (NM), a product dopamine metabolism that accumulates in substantia nigra (SN). Prior work has shown NM-MRI provides marker SN integrity Parkinson’s disease. Here, we show it may additionally provide function human nigrostriatal pathway. Supporting this, found signal correlated with NM concentration, levels striatum, blood flow, and severity psychosis schizophrenia, all absence neurodegeneration....
Abstract Rationale Second-generation antipsychotics occupy dopamine D 2 receptors and act as antagonists or partial agonists at these receptors. While drugs alleviate positive symptoms in patients with schizophrenia, they are less effective for treating cognitive deficits negative symptoms. Dopamine 3 highly expressed areas of the brain thought to play a role regulation motivation reward-related behavior. Consequently, receptor has become target combination antagonism treat schizophrenia....
Despite strong theoretical rationale and preclinical evidence, several glutamate-targeted treatments for schizophrenia have failed in recent pivotal trials, prompting questions as to target validity, compound inadequacy, or lack of engagement. A key limitation glutamate-based treatment development is the functional target-engagement biomarkers translation between early-stage clinical studies. We evaluated utility 3 potential biomarkers-ketamine-evoked changes magnetic imaging (fMRI) blood...
Social functioning (SF) difficulties are ubiquitous among individuals at clinical high risk for psychosis (CHR), but it is not yet clear why. One possibility suggested by the observation that effective SF requires adaptive emotion awareness and regulation. Previous reports have documented deficits in regulation with schizophrenia, shown such predicted SF. However, unknown whether these present prior to onset of or they linked CHR individuals.We conducted a cross-sectional comparison 54 CHR,...