A5002768109- Functional Brain Connectivity Studies
- Neural and Behavioral Psychology Studies
- Schizophrenia research and treatment
- Advanced Neuroimaging Techniques and Applications
- Neural dynamics and brain function
- Advanced MRI Techniques and Applications
- Neurological disorders and treatments
- Neurotransmitter Receptor Influence on Behavior
- EEG and Brain-Computer Interfaces
- Mental Health and Psychiatry
- Neuroscience and Music Perception
- Medical Imaging Techniques and Applications
- Mental Health Research Topics
- Sport Psychology and Performance
- Treatment of Major Depression
- Free Will and Agency
- Bipolar Disorder and Treatment
- Cognitive Abilities and Testing
- Psychosomatic Disorders and Their Treatments
- Memory and Neural Mechanisms
- Attention Deficit Hyperactivity Disorder
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Heart Rate Variability and Autonomic Control
- Nicotinic Acetylcholine Receptors Study
- Nuclear Receptors and Signaling
Stony Brook University
2018-2025
Stony Brook School
2019-2025
Columbia University
2009-2024
New York State Psychiatric Institute
2012-2024
New York Psychoanalytic Society and Institute
2011-2024
Renaissance University
2021-2024
Columbia University Irving Medical Center
2016-2022
Stony Brook Medicine
2020-2021
Stony Brook University Hospital
2020
Columbia College
2014
<h3>Importance</h3> Multiple lines of evidence suggest a deficit in dopamine release the prefrontal cortex (PFC) schizophrenia. Despite prevalence concept cortical hypodopaminergia schizophrenia, vivo imaging PFC has not been possible until now, when validity using positron emission tomographic D2/3 radiotracer carbon 11–labeled FLB457 combination with amphetamine paradigm was clearly established. <h3>Objectives</h3> To (1) test amphetamine-induced dorsolateral (DLPFC) drug-free or...
Despite the well-established role of striatal dopamine in psychosis, current views generally agree that cortical dysfunction is likely necessary for emergence psychotic symptoms. The topographic organization striatal-cortical connections central to gating and integration higher-order information, so a disruption such topography via dysregulated could lead schizophrenia. However, this hypothesis remains be tested using multivariate methods ascertaining global pattern connectivity without...
Background: Evidence from preclinical and human studies indicates the presence of reduced dopamine-1 receptor (D1R) signaling in cortex, where D1Rs predominate, patients with schizophrenia (SCZ), which may contribute to their cognitive deficits. Furthermore, nonhuman primates (NHP) have suggested that intermittent administration low doses D1R agonists produce long-lasting reversals The purpose this trial was test whether a similar design, involving subacute full, selective agonist at D1Rs,...
We investigated judgements of agency in participants with schizophrenia and healthy controls. Participants engaged a computer game which they attempted to touch downward falling Xs avoid touching Os. On some trials, were objectively perfect control. other not complete control because the movement cursor on screen was distorted respect position mouse by random noise (turbulence), or it lagged 250 500 ms. made metacognitive as well performance. Control participants' affected turbulence lag...
Abstract Despite significant advances in understanding how brain networks support working memory (WM) and cognitive control, relatively little is known about these respond when capabilities are overtaxed. We used a fine‐grained manipulation of load within single trial to exceed WM capacity during functional magnetic resonance imaging investigate task performance exceeded. Analyzing correct trials only, we observed nonmonotonic (inverted‐U) response throughout the classic network (including...
Recent findings demonstrate that patients with schizophrenia are worse at learning to predict rewards than losses, suggesting motivational context modulates in this disease. However, these derive from studies treated antipsychotic medications, D2 receptor antagonists may interfere the neural systems underlie motivation and learning. Thus, it remains unknown how affects schizophrenia, separate effects of medication. To examine impact on we tested 16 unmedicated 23 matched controls a...
Abstract Patients with schizophrenia have a high prevalence of cigarette smoking and respond poorly to conventional treatments, highlighting the need for new therapies. We conducted mechanistic, proof-of-concept study using bilateral deep repetitive transcranial magnetic stimulation (dTMS) insular prefrontal cortices at frequency, specialized H4 coil. Feasibility dTMS was tested disruption tobacco self-administration, insula target engagement, circuit modulation, all which were priori...
ABSTRACT In studying the neural correlates of working memory (WM) ability via functional magnetic resonance imaging (fMRI) in health and disease, it is relatively uncommon for investigators to report associations between brain activation measures task performance. Additionally, how choice WM impacts observed activation–performance relationships poorly understood. We sought illustrate impact on brain–behavior correlations using two large, publicly available datasets. conducted...
In prior work, a transgenic mouse model of the striatal dopamine dysfunction observed in persons with schizophrenia (PSZ) exhibited dopamine-related neuroplasticity basal ganglia. This phenotype has never been demonstrated human PSZ. To identify specific alteration ganglia connectivity via task-based and resting-state functional magnetic resonance imaging (fMRI), neuromelanin-sensitive MRI (NM-MRI), positron emission tomography (PET), unmedicated case-control study PSZ healthy controls (HC)...
Despite decades of research, cognitive impairment remains a critical untreated symptom for many patients with schizophrenia. One way to accelerate the development pro-cognitive therapies schizophrenia is evaluate compounds using biomarker approaches tailored relevant neural mechanisms. While D1/D5 receptor (D1R/D5R) agonism has been extensively studied in neuroscience, its therapeutic potential untapped. The Translational Neuroscience & Computational Evaluation D1R Partial Agonist...
Connectivity between brain networks may adapt flexibly to cognitive demand, a process that could underlie adaptive behaviors and deficits, such as those observed in neuropsychiatric conditions like schizophrenia. Dopamine signaling is critical for working memory but its influence on internetwork connectivity relatively unknown. We addressed these questions healthy humans using functional magnetic resonance imaging (during an n -back working-memory task) positron emission tomography the...
Abstract Decades of research have highlighted the importance optimal stimulation cortical dopaminergic receptors, particularly D1R receptor (D1R), for prefrontal-mediated cognition. This mechanism is relevant to cognitive deficits in schizophrenia, given abnormalities dopamine (DA) neurotransmission and expression D1R. Despite critical need D1R-based therapeutics, many factors complicated their development prevented this important therapeutic target from being adequately interrogated....
Simultaneous multi-slice (multiband) accelerated functional magnetic resonance imaging (fMRI) provides dramatically improved temporal and spatial resolution for resting-state connectivity (RSFC) studies of the human brain in health disease. However, multiband acceleration also poses unique challenges denoising subject motion induced data artifacts, presence which is a major confound RSFC research that substantively diminishes reliability reproducibility. We comprehensively evaluated existing...