A5007496748- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Schizophrenia research and treatment
- Functional Brain Connectivity Studies
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Treatment of Major Depression
- Medical Imaging Techniques and Applications
- Neurological disorders and treatments
- Advanced MRI Techniques and Applications
- Pain Mechanisms and Treatments
- Tryptophan and brain disorders
- Bipolar Disorder and Treatment
- Animal Behavior and Welfare Studies
- Electroconvulsive Therapy Studies
- Advanced Neuroimaging Techniques and Applications
- Pharmacological Effects and Toxicity Studies
- Stress Responses and Cortisol
- Hormonal and reproductive studies
- Fatty Acid Research and Health
- Neural and Behavioral Psychology Studies
- Lanthanide and Transition Metal Complexes
- Genetic and phenotypic traits in livestock
- Reproductive Physiology in Livestock
- Opioid Use Disorder Treatment
University of Pittsburgh
2015-2024
Università di Camerino
2019
VA Connecticut Healthcare System
2014-2017
Yale University
2014-2017
Southwestern Medical Center
2016-2017
The University of Texas Southwestern Medical Center
2016-2017
University of Pittsburgh Medical Center
2015
Research Institute of Radiology
2014
Columbia University
2004-2012
UPMC Presbyterian
2011
<h3>Importance</h3> Multiple lines of evidence suggest a deficit in dopamine release the prefrontal cortex (PFC) schizophrenia. Despite prevalence concept cortical hypodopaminergia schizophrenia, vivo imaging PFC has not been possible until now, when validity using positron emission tomographic D2/3 radiotracer carbon 11–labeled FLB457 combination with amphetamine paradigm was clearly established. <h3>Objectives</h3> To (1) test amphetamine-induced dorsolateral (DLPFC) drug-free or...
Dopamine is an important mediator of the reinforcing effects cocaine, and alterations in dopamine function might be involved cocaine dependence. The goals present study were to characterize pre- postsynaptic recently detoxified cocaine-dependent subjects. Specifically, response acute amphetamine challenge was assessed striatal subregions healthy comparison participants using positron emission tomography (PET). Furthermore, relationship between this choice self-administer a laboratory model...
[11C]PHNO is a recently introduced agonist to image DA D2-like receptors with Positron Emission Tomography (PET). In cats and humans, revealed an atypical distribution compared radiolabeled antagonists (such as [11C]raclopride) or other agonists [11C]NPA), it displayed unusual high binding in the globus pallidus (GP). The goal of this study was assess pharmacological nature GP nonhuman primates. As previously reported equilibrium specific nonspecific partition coefficients (V3'') baboons...
Objective: Previous positron emission tomography (PET) imaging studies have demonstrated that cocaine dependence is associated with a decrease in dopamine type 2 and 3 (D /D ) receptor binding cocaine-dependent individuals relative to healthy comparison subjects. However, given the nature of PET imaging, it possible measured radiotracer results from an increase baseline levels. The purpose this study was measure D receptors following acute depletion volunteers Method: Cocaine-dependent...
Objective: Postmortem studies in schizophrenia reveal alterations gene products that regulate the release and extracellular persistence of GABA. However, results vivo measuring total tissue GABA with magnetic resonance spectroscopy (MRS) have been inconsistent. Neither postmortem nor MRS directly address physiological properties neurotransmission. The present study addresses this question through an innovative positron emission tomography (PET) paradigm. Method: binding [11C]flumazenil, a...
OBJECTIVE: Ketamine is a noncompetitive antagonist at the glutamatergic N-methyl-d-aspartate (NMDA) receptor that used in human and animal medicine as an injectable anesthetic. The illegal use of ketamine recreational drug rapidly growing. Very little currently known about consequences repeated exposure brain. Animal studies indicate prefrontal dopaminergic system particularly vulnerable to toxic effects administration NMDA antagonists. In this study, dopamine D1 availability was assessed by...
Abstract (–)‐N‐Propyl‐norapomorphine (NPA) is a full dopamine (DA) D 2 receptor agonist and [ 11 C]NPA suitable radiotracer to image receptors configured in state of high affinity for agonists with positron emission tomography (PET). In this study the vulnerability vivo binding acute fluctuation synaptic DA was assessed PET baboons compared that reference antagonist C]raclopride. Three male were studied C]raclopride under baseline conditions following administration potent releaser...
Article AbstractBackground: In controlled studies of patientswith schizophrenia, the atypical antipsychotic olanzapine hasbeen shown to be more effective in treatment positive andnegative symptoms compared with haloperidol at doses 10mg/day. However, little is known about efficacy olanzapinein patients psychotic mood disorders. The purpose thisstudy was assess treatmentof these disorders comparison nonaffectivepsychotic and identify clinical factors associatedwith response. Method: a...
The use of PET and SPECT endogenous competition binding techniques has contributed to the understanding role dopamine in several neuropsychiatric disorders. An important limitation these imaging studies is fact that measurements acute changes synaptic have been restricted striatum. ligands previously used, such as [(11)C]raclopride [(123)I]IBZM, do not provide sufficient signal noise ratio quantify D(2) receptors extrastriatal areas, cortex, where concentration much lower than Given...
Although altered function in neural reward circuitry is widely proposed models of addiction, more recent conceptual views have emphasized the role disrupted response prefrontal regions. Changes regions such as orbitofrontal cortex, medial and dorsolateral cortex are postulated to contribute compulsivity, impulsivity, executive that central addiction. In addition, few studies examined these during young adulthood, when exposure less chronic than typical samples alcohol-dependent adults. To...
(-)-N-Propyl-norapomorphine (NPA) is a full dopamine D(2/3) receptor agonist, and [(11)C]NPA suitable radiotracer to image receptors configured in state of high affinity for agonists with positron emission tomography (PET). In this study, the vulnerability vivo binding [11C]NPA acute fluctuation synaptic was assessed PET healthy humans compared that reference antagonist [11C]raclopride. Ten subjects (eight females two males) were studied on separate days, minimum 1 week apart, both...
Objective Basic studies have demonstrated that optimal levels of prefrontal cortical dopamine are critical to various executive functions such as working memory, attention, inhibitory control, and risk/reward decisions, all which impaired in addictive disorders alcoholism. Based on this imaging alcoholism less the striatum, authors hypothesized decreased transmission cortex persons with alcohol dependence. Method To test hypothesis, amphetamine [11C]FLB 457 positron emission tomography were...
Basic science investigations have consistently shown that repeated exposure to psychostimulant drugs, such as cocaine, activate the immune response and lead inflammatory changes in brain. No previous <i>in vivo</i> studies confirmed this observation chronic cocaine-abusing humans. To test hypothesis, we used positron emission tomography imaging measure binding of [<sup>11</sup>C]PBR28 18 kDa translocator protein (TSPO), a marker for microglial activation group 15 recently abstinent cocaine...
Abstract Objective: Genetic, pharmacologic, and physiological data suggest that individuals with anorexia nervosa (AN) have altered striatal dopamine (DA) function. Method: We used an amphetamine challenge positron emission tomography [ 11 C]raclopride paradigm to explore DA transmission in 10 recovered (REC) AN compared 9 control women (CW). Results: REC CW were similar for baseline, postamphetamine binding potential (BP ND ) change (Δ) BP all regions. In CW, ventral striatum Δ was...
Objective: Positron emission tomography (PET) imaging studies in cocaine abusers have shown that low dopamine release the striatum following an amphetamine challenge is associated with higher relapse rates. One possible mechanism might lead to lower amphetamine-induced availability of storage vesicles presynaptic terminals for release. Consistent this hypothesis, postmortem levels vesicular monoamine transporter, type 2 (VMAT2), membrane protein regulates size pool, relative healthy...
Abstract In a recent PET study, we demonstrated the ability to measure amphetamine‐induced DA release in human cortex with relatively high affinity dopamine D 2/3 radioligand [ 11 C]FLB 457 (Narendran et al., [2009] Synapse 63:447–461). The aim of this study was evaluate reproducibility and reliability same imaging paradigm used transmission. Six healthy subjects (three males/three females) were studied twice 457, once at baseline again 3 h following end scan. receptor binding parameters...
Evidence indicates that synchronization of cortical activity at gamma-band frequencies, mediated through GABA-A receptors, is important for perceptual/cognitive processes. To study GABA signaling in vivo, we recently used a novel positron emission tomography (PET) paradigm measuring the change binding benzodiazepine (BDZ) site radiotracer [11C]flumazenil associated with increases extracellular induced via membrane transporter (GAT1) blockade tiagabine. GAT1 resulted significant potential...