A5102854362- Functional Brain Connectivity Studies
- Obsessive-Compulsive Spectrum Disorders
- Neural and Behavioral Psychology Studies
- Neural dynamics and brain function
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Eating Disorders and Behaviors
- EEG and Brain-Computer Interfaces
- Mental Health Research Topics
- Advanced Neuroimaging Techniques and Applications
- Attention Deficit Hyperactivity Disorder
- Infant Health and Development
- Autism Spectrum Disorder Research
- Memory and Neural Mechanisms
- Psychosomatic Disorders and Their Treatments
- Blind Source Separation Techniques
- Image and Signal Denoising Methods
- Treatment of Major Depression
- Advanced MRI Techniques and Applications
- Child and Adolescent Psychosocial and Emotional Development
- Gastrointestinal motility and disorders
- Neurotransmitter Receptor Influence on Behavior
- Neurobiology of Language and Bilingualism
- Neuroscience and Music Perception
- Behavioral Health and Interventions
- Body Image and Dysmorphia Studies
New York State Psychiatric Institute
2012-2024
Columbia University
2014-2024
New York Psychoanalytic Society and Institute
2013-2022
Columbia University Irving Medical Center
2017-2022
University of California, San Diego
2018
New York College of Health Professions
2011-2015
Tsinghua University
2010-2012
University Physicians
2011
University of Geneva
2011
Lynn University
1999-2002
The purpose of this study was to examine neural activity and connectivity within cortico-striato-thalamo-cortical circuits reveal circuit-based mechanisms that govern tic generation in Tourette's syndrome.Functional magnetic resonance imaging data were acquired from 13 individuals with syndrome 21 healthy comparison subjects during spontaneous or simulated tics. Independent component analysis hierarchical partner matching used isolate functionally distinct regions circuits. Granger causality...
The circumplex model of affect construes all emotions as linear combinations 2 independent neurophysiological dimensions, valence and arousal. We used functional magnetic resonance imaging to identify the neural networks subserving arousal, we assessed, in 10 participants, associations BOLD (blood oxygen level-dependent) response, an indirect index activity, with ratings arousal during emotional experiences induced by presentation evocative sentences. Unpleasant experience was associated...
The default mode network (DMN) is a collection of brain regions that reliably deactivate during goal-directed behaviors and more active baseline, or so-called resting, condition. Coherence neural activity, functional connectivity, within the brain's DMN increased in major depressive disorder relative to healthy control (HC) subjects; however, whether similar abnormalities are present persons with dysthymic (DD) unknown. Moreover, effect antidepressant medications on connectivity patients DD...
Objective: The authors examined the effect of psychostimulants on brain activity in children and adolescents with ADHD performing Stroop Color Word Test. Method: acquired 52 functional MRI scans 16 youths who were known responders to stimulant medication 20 healthy comparison youths. Participants scanned off a counterbalanced design, subjects once without medication. Results: Stimulant significantly improved suppression default-mode ventral anterior cingulate cortex group. When medication,...
Abstract Objective: We aimed to study the neural processing of emotion‐denoting words based on a circumplex model affect, which posits that all emotions can be described as linear combination two neurophysiological dimensions, valence and arousal. Based model, we predicted relationship between activity incremental changes in these affective dimensions. Methods: Using functional magnetic resonance imaging, assessed 10 subjects correlations BOLD (blood oxygen level dependent) signal with...
<h3>Context</h3> Disturbances in neural systems that mediate voluntary self-regulatory processes may contribute to bulimia nervosa (BN) by releasing feeding behaviors from regulatory control. <h3>Objective</h3> To study the functional activity circuits subserve control women with BN. <h3>Design</h3> We compared magnetic resonance imaging blood oxygenation level–dependent responses patients BN healthy controls during performance of Simon Spatial Incompatibility task. <h3>Setting</h3>...
The authors examined functional activity in the frontostriatal systems that mediate self-regulatory capacities and conflict resolution adolescents with bulimia nervosa.Functional magnetic resonance imaging was used to compare blood-oxygen-level-dependent response 18 female nervosa healthy age-matched subjects during performance on a Simon spatial incompatibility task. Bayesian analyses were two groups patterns of brain activation correct responses stimuli explore effects antecedent stimulus...
Objective: Disturbances in the maturation of neural systems that mediate self-regulatory processes may contribute to development Tourette's syndrome by releasing motor and vocal tics from regulatory control. The purpose this study was examine age correlates functional activity circuits subserve control children adults with syndrome. Method: participants were 136 adults, which included 66 patients 70 healthy comparison subjects. During performance Stroop interference task, authors compared...
We report the design and fabrication of Al/poly(3,4-ethylene-dioxythiophene):poly(styrenesulfonate) (PEDOT:PSS)/Cu resistive memory devices that utilize Cu redox reaction conformational features PEDOT:PSS to achieve switching. The top electrode acts as source ions are injected through layer during forming process. filament is confirmed directly using cross-sectional images transmission electron microscopy energy-dispersive X-ray spectroscopy. resultant can operate over a small voltage range,...
The authors sought to study activity in neural circuits that subserve the inhibition of a semi-involuntary motor behavior, eye blinking, children and adults with Tourette syndrome healthy comparison subjects.Functional magnetic resonance imaging was used scan 120 participants (51 69 subjects) as they either blinked normally or successfully inhibited blinking. compared blood-oxygen-level dependent signal during these two conditions across groups.Relative subjects, patients activated more...
This study tested whether mothers with interpersonal violence-related posttraumatic stress disorder (IPV-PTSD) vs healthy controls (HC) would show greater limbic and less frontocortical activity when viewing young children during separation compared to quiet play. Mothers of 20 (12-42 months) participated: 11 IPV-PTSD 9 HC no PTSD. During fMRI, watched epochs play from their own unfamiliar children. The focused on comparison PTSD in play, separation. Both groups showed distinct patterns...
Neural disruptions during emotion regulation are common of generalized anxiety disorder (GAD). Identifying distinct functional and effective connectivity patterns in GAD may provide biomarkers for their diagnoses. This study aims to investigate the differences features brain network between patients healthy controls, assess whether those can serve as distinguish from controls. Independent component analysis with hierarchical partner matching (HPM-ICA) was conducted on resting-state magnetic...
Differing imaging modalities provide unique channels of information to probe differing aspects the brain's structural or functional organization. In combination, complementary and mutually informative data about tissue organization that is more than their sum. We acquired spatially coregistered in four MRI modalities--anatomical MRI, diffusion tensor (DTI), magnetic resonance spectroscopy (MRS)--from 20 healthy adults understand how interindividual variability measures from one modality...
Major depressive disorder (MDD) is approximately twice as common in females than males. Furthermore, female patients with MDD tend to manifest comorbid anxiety. Few studies have explored the potential anatomical and functional brain changes associated females. Therefore, purpose of present study was investigate underlying females, especially within context anxiety.In this study, we recruited antidepressant-free (N = 35) healthy controls (HC; N 23). The severity depression anxiety were...
Behavioral interference elicited by competing response tendencies adapts to contextual changes. Recent nonhuman primate research suggests a key mnemonic role of distinct prefrontal cells in supporting such context-driven behavioral adjustments maintaining conflict information across trials, but corresponding functions have yet be probed humans. Using event-related functional magnetic resonance imaging, we investigated the human neural substrates adaptations conflict. We found that system...
The neural systems that confer risk or vulnerability for developing familial depression, and those protect against resilience to becoming ill, can be disentangled from the effects of prior illness by comparing brain imaging measures in previously ill never persons who have either a high low depression.To distinguish endophenotypes major depression lifetime illness.We used functional magnetic resonance measure compare function during performance an attentional, self-regulatory task across...