A5017269298- Tryptophan and brain disorders
- Treatment of Major Depression
- Functional Brain Connectivity Studies
- Mental Health Research Topics
- Wheat and Barley Genetics and Pathology
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Stress Responses and Cortisol
- Plant Disease Resistance and Genetics
- Bipolar Disorder and Treatment
- Child and Adolescent Psychosocial and Emotional Development
- RNA modifications and cancer
- Dementia and Cognitive Impairment Research
- Maternal Mental Health During Pregnancy and Postpartum
- Cancer Cells and Metastasis
- Autism Spectrum Disorder Research
- ECG Monitoring and Analysis
- Circular RNAs in diseases
- Genetic Associations and Epidemiology
- Nerve injury and regeneration
- Stroke Rehabilitation and Recovery
- Identity, Memory, and Therapy
- Neural and Behavioral Psychology Studies
- Digital Mental Health Interventions
- Psychosomatic Disorders and Their Treatments
Zhongda Hospital Southeast University
2013-2024
Huanghuai University
2024
Sichuan Academy of Agricultural Sciences
2019-2023
Institute of Plant Protection
2014-2023
Southeast University
2010-2022
Nanjing Medical University
2011-2020
Jiangsu Province Hospital
2011-2020
Army Medical University
2004-2018
Xinqiao Hospital
2018
Sheffield Hallam University
2016
Recently, long noncoding RNAs (lncRNAs) have been shown to important regulatory roles in human cancer biology. By utilizing publicly available lncRNAs expression profiling data and integrating analyses, we screened out LINC00668, whose is significantly increased correlated with outcomes gastric (GC). Further experiments revealed that LINC00668 knockdown repressed proliferation, both vitro vivo. Mechanistic investigations showed was a direct transcriptional target of E2F transcription factor...
Objective: Depression is a common mood disorder affecting stroke patients. It associated with poorer outcome and increased mortality in The aim of this work was to test whether serum levels proinflammatory cytokines are correlated the development depression after stroke. Methods: One hundred ischemic patients admitted hospital within first 24 hours onset were consecutively recruited followed up for 6 months. 17-item Hamilton Rating Scale (HDRS) Montgomery–Åsberg (MADRS) used screen...
Objective This study was to test whether serum BDNF or tissue plasminogen activator (tPA) is correlated with the development of depression at acute stage stroke. Methods Hundred ischemic stroke patients admitted hospital within first 24 h onset were consecutively recruited and followed up for 14 days. The 17-item HDRS MADRS used assess severity major depressive symptoms on day 3, 7, after admission. diagnoses made in accordance DSM-IV criteria post-stroke (PSD). Serum tPA all determined by...
Variation in genes implicated serotonin neurotransmission may interact with environmental factors to influence antidepressant response. We aimed determine how a range of polymorphisms serotonergic this response treatment and they childhood trauma recent life stress Chinese sample. In total, 14 single nucleotide (SNPs) coding regions 10 ( HTR1A, HTR1B, HTR1D, HTR2A, HTR3A, HTR3C, HTR3D, HTR3E, HTR5A TPH2) were genotyped 308 Han patients major depressive disorder. Response 6 weeks’ was...
Major depressive disorder (MDD) is approximately twice as common in females than males. Furthermore, female patients with MDD tend to manifest comorbid anxiety. Few studies have explored the potential anatomical and functional brain changes associated females. Therefore, purpose of present study was investigate underlying females, especially within context anxiety.In this study, we recruited antidepressant-free (N = 35) healthy controls (HC; N 23). The severity depression anxiety were...
Aim: To investigate the role of genetic polymorphisms in glutamatergic and GABAergic genes their interactions with environmental stressors antidepressant response. Methods: A set 114 SNPs 34 genes, mainly promoter coding regions, were genotyped 281 Chinese Han major depressive disorder patients. The 17-item Hamilton Depression Rating Scale was used to evaluate symptom severity therapeutic efficacy. Childhood Trauma Questionnaire Life Events for assessing early-onset recent stressful life...
Breeding for resistance to stripe rust (caused by Puccinia striiformis f. tritici) is essential reducing losses in yield and quality wheat. To identify genes use breeding, a biparental population of 186 recombinant inbred lines (RILs) from cross the Chinese landrace Mingxian 169 CIMMYT-derived line P9936 was evaluated field nurseries either artificially or naturally inoculated two crop seasons. Each RILs parents genotyped with wheat 55K single-nucleotide polymorphism (SNP) 'Breeders' array...
BACKGROUND:The hedgehog (Hh) pathway has been implicated in the pathogenesis of cancer including pancreatic ductal adenocarcinoma (PDAC). Recent studies have suggested that Hh plays an important role maintaining stem cell (CSCs) pool. Gemcitabine-resistant cells highly express some CSCs markers. However, expression level members gemcitabine-resistant remains unknown. The aim this study was to verify HH members, such as Shh, Ptc, SMO and Gli-1 PDAC lines, explore a new strategy overcome...
Abstract Mental disorders are severe, disabling conditions with unknown etiology and commonly misdiagnosed when clinical symptomology criteria solely used. Our previous work indicated that combination of serum levels multiple proteins in tissue plasminogen activator (tPA)-brain-derived neurotrophic factor (BDNF) pathway improved accuracy diagnosis major depressive disorder (MDD). Here, we measured tPA, inhibitor-1 (PAI-1), BDNF, precursor-BDNF (proBDNF), tropomyosin-related kinase B (TrkB)...
Variation in genes implicated monoamine neurotransmission may interact with environmental factors to influence antidepressant response. We aimed determine how a range of single nucleotide polymorphisms monoaminergic this response treatment and they childhood trauma recent life stress Chinese sample. An initial study coding region identified significant associations TPH2 HTR1B that showed interactions stress, respectively (Xu et al., 2012). A total 47 further 17 candidate were genotyped 281...
Abstract Introduction Somatic symptom disorder ( SSD ) is an illness that occurs over a long time and results in significant disruption daily life. Clinically, patients typically express complaints involve variety of organ systems. However, the neural mechanism remains poorly understood. Methods Using resting‐state functional magnetic resonance imaging, we investigated characteristics regional basal brain function during resting state with . Eleven treatment‐naïve 12 age‐matched healthy...
Abstract Background Most antidepressants have been developed on the basis of monoamine deficiency hypothesis depression, in which neuronal serotonin (5-HT) plays a key role. 5-HT biosynthesis is regulated by rate-limiting enzyme tryptophan hydroxylase-2 (TPH2 ). TPH2 methylation correlated with antidepressant effects. Resting-state functional MRI (rs-fMRI) applied for detecting abnormal brain activity patients different We will investigate effect interaction between rs-fMRI and DNA early...
Shumian capsule (SMC) is a patent Chinese herbal medicine that can soothe the liver and relieves depression, quiet spirit. Here, we aimed to investigate efficacy of SMC for treating insomnia using both scales polysomnography (PSG).A randomized, double-blind, placebo-controlled trial was performed. Twenty-six patients randomly received (n = 11) or placebo 15) four weeks. Pittsburgh Sleep Quality Inventory (PSQI), Insomnia Severity Index (ISI), 9-items Patient Health Questionnaire (PHQ-9),...
Abstract In order to determine the role of single nucleotide variants (SNVs) in modulating antidepressant response, we conducted a study, consisting 929 major depressive disorder (MDD) patients, who were treated with drugs (drug-only) or combination repetitive transcranial magnetic stimulation (plus-rTMS), followed by targeted exome sequencing analysis. We found that “plus-rTMS” patients presented more effective response treatment when compared ‘drug-only’ group. Our data firstly...
Abstract Objective To identify DNA methylation and clinical features, to construct machine learning classifiers assign the patients with major depressive disorder (MDD) into responders non-responders after a 2-week treatment non-responders. Method Han Chinese (291 in total) MDD comprised study population. Datasets contained demographic information, environment stress factors, levels of 38 methylated sites tryptophan hydroxylase 2 (TPH2) genes peripheral blood samples. Recursive Feature...
To investigate the relationship between amnestic mild cognitive impairment (aMCI) and candidate gene polymorphisms in a Chinese population, 116 aMCI patients 93 normal controls were recruited. Multi-dimensional neuropsychological tests used to extensively assess functions of subjects. MassARRAY iPLEX systems measure single nucleotide polymorohisms (SNPs) analyse allelic, genotypic or haplotypic distributions. The scores significantly lower for than controls. distributions SNPs relating...