A5017958306- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Advanced Neuroimaging Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Acute Ischemic Stroke Management
- Epilepsy research and treatment
- Functional Brain Connectivity Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cerebrospinal fluid and hydrocephalus
- Inflammatory Biomarkers in Disease Prognosis
- Neurological Disorders and Treatments
- Pharmacological Effects and Toxicity Studies
- Advanced MRI Techniques and Applications
- Spinal Dysraphism and Malformations
- Cerebrovascular and Carotid Artery Diseases
- Treatment of Major Depression
- Folate and B Vitamins Research
- Kruppel-like factors research
- Healthcare Systems and Practices
- Acute Myeloid Leukemia Research
- Alzheimer's disease research and treatments
- Neuroendocrine regulation and behavior
- Venous Thromboembolism Diagnosis and Management
- Birth, Development, and Health
Zhongda Hospital Southeast University
2013-2024
Southeast University
2014-2020
Background:Although progress has been made in the detection and characterization of neural plasticity depression, it not fully understood individual synaptic changes circuits under chronic stress antidepressant treatment.
Aim: To investigate the role of genetic polymorphisms in glutamatergic and GABAergic genes their interactions with environmental stressors antidepressant response. Methods: A set 114 SNPs 34 genes, mainly promoter coding regions, were genotyped 281 Chinese Han major depressive disorder patients. The 17-item Hamilton Depression Rating Scale was used to evaluate symptom severity therapeutic efficacy. Childhood Trauma Questionnaire Life Events for assessing early-onset recent stressful life...
Background Collateral status assessed with single- or multiphase CT angiography can be used to predict outcome in patients acute ischemic stroke (AIS); however, little is known about whether these measures could comparable perfusion parameters. Purpose To compare the predictive ability of collateral score systems and parameters determining clinical outcomes AIS. Materials Methods In this retrospective study, data obtained from October 2017 August 2018 consecutive AIS caused by isolated...
Summary Aims To investigate the role of genetic polymorphisms in candidate genes associated with HPA axis and their interactions environmental stressors antidepressant response. Methods The remission depressive symptoms after 8 weeks treatment was tested against 21 single nucleotide ( SNP s) five a Chinese Han sample suffering from unipolar depression (n = 273). Any history childhood trauma recent negative life events were measured using Childhood Trauma Questionnaire‐Short Form CTQ ‐ SF )...
Elderly epilepsy is the third most common chronic disease that affects metabolism either alone or through antiepileptic drugs (AEDs). Here, we focus on whether neurocognitive profiles in elderly and its treatment are linked to metabolic conditions.Elderly patients with without cognitive impairment (n = 78) 75) were enrolled. C-reactive protein (CRP) markers (triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL-c), low-density (LDL-c), albumin, fasting glucose (Glu)...
BACKGROUND:Due to the lack of validation for predictive scoring stroke-associated pneumonia in both thrombolysis- and nonthrombolysis-treated ischemic stroke (IS) patients, this study aimed evaluate 4 methods 2 subgroups. MATERIAL AND METHODS:The CerebroVascular Database Project database included data from patients with cerebral IS that were admitted hospitals February 2016 January 2018. A total 138 thrombolysis-treated enrolled. Area under receiver operating characteristic curves (AUROC)...
Conventional MRI is limited in diagnosis of subtle epileptic lesions. Therefore, this study aimed to localize lesions by using MRF technology. Twenty epilepsy patients were included which underwent T1, T2 and examinations. The spatially normalized the symmetric ICBM-152 template, followed transformation T1 maps. Absolute asymmetric index (|AI|) analysis was then performed on maps detect Results showed that |AI| can epileptogenic foci 75% patients. In conclusion, asymmetry could help improve...
To explore the influence of interleukin-1 beta (IL1B) gene polymorphism and childhood maltreatment on antidepressant treatment.Two hundred four patients with major depressive disorder (MDD) have received treatment single drugs were followed up for 8 weeks. Hamilton depression scale-17 (HAMD-17) was used to evaluate severity symptoms therapeutic effect. Childhood assessed using Trauma Questionnaire, a 28-item Short Form (CTQ-SF). Single nucleotide (SNP) IL1B determined SNaPshot method....
Abstract Background Essential thrombocythemia (ET) is a myeloproliferative neoplasm characterized by elevated and dysfunctional platelets. ET can result in systemic thrombotic hemorrhagic complications, it’s rare cause of stroke. The coexistence multiple vascular lesions has seldom been reported patients with essential thrombocythemia. Case presentation A young woman presented isolated persistent vertigo vomiting. CT scan indicated hyperdense lesion the right cerebellar hemisphere. No signs...
Childhood physical neglect (CPN) is a common but often overlooked form of abuse that may contribute to depression. We aimed at examining the potential impact CPN and its interactions with genes related oligodendrocytes (ODCs) myelin function on adult depressive symptoms antidepressant treatment response. Methods: A group 209 Chinese Han patients major disorder (MDD) completed Hamilton Depression Scale-17 (HAMD-17) baseline after 8 weeks treatment. The Trauma Questionnaire was used evaluate...
To assess the influence of polymorphisms methylenetetrahydrofolate reductase (MTHFR) gene on response to antidepressant treatment.Two hundred and eight one Chinese Han patients have received single drugs for at least 6 weeks, among whom 275 were followed up 8 weeks. Hamilton depression scale 17 (HAMD-17) was used evaluate severity depressive symptoms therapeutic effects. Single nucleotide (SNPs) MTHFR determined using chips. Associations loci haplotypes with treatment analyzed an Unphased...