A5100708886- HER2/EGFR in Cancer Research
- Monoclonal and Polyclonal Antibodies Research
- MicroRNA in disease regulation
- Neonatal Respiratory Health Research
- Neonatal and fetal brain pathology
- Medical Research and Treatments
- Anesthesia and Pain Management
- Cytokine Signaling Pathways and Interactions
- Cancer-related molecular mechanisms research
- Glycosylation and Glycoproteins Research
- Pregnancy and preeclampsia studies
- Cardiovascular Health and Risk Factors
- Nausea and vomiting management
- Cardiovascular Health and Disease Prevention
- Metabolism and Genetic Disorders
- Cancer-related gene regulation
- Congenital Heart Disease Studies
- Inflammatory Bowel Disease
- Cardiovascular and Diving-Related Complications
- Cardiovascular Issues in Pregnancy
- Anesthesia and Sedative Agents
- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Neutropenia and Cancer Infections
- Connexins and lens biology
Chengdu Women's and Children's Central Hospital
2024
University of Electronic Science and Technology of China
2024
Zhejiang Taizhou Hospital
2009-2024
Wenzhou Medical University
2009-2024
Zhejiang University
2011-2024
Shaanxi University of Chinese Medicine
2023
Air Force Medical University
2023
Tang Du Hospital
2023
Quzhou City People's Hospital
2023
Affiliated Hospital of Shaanxi University of Chinese Medicine
2023
A series of terpene isonitriles, isolated from marine sponges, have previously been shown to exhibit antimalarial activities. Molecular modeling studies employing 3D-QSAR with receptor methodologies performed these isonitriles showed that the modeled molecules could be used generate a pharmacophore hypothesis consistent experimentally derived biological It was also one compounds, diisocyanoadociane (4), as well axisonitrile-3 (2), both which potent activity, interacts heme (FP) by forming...
// Tie-Feng Song 1, * , Li-Wen Huang Ying Yuan 1 Hui-qin Wang Hong-Peng He Wen-Jian Ma Li-Hong Huo Hao Zhou Nan and Tong-Cun Zhang 2 Key Laboratory of Industrial Fermentation Microbiology, Ministry Education Tianjin, College Biotechnology, Tianjin University Science Technology, 300457, P.R. China Institute Biology Medicine, Wuhan 430000, These authors contributed equally to this work Correspondence to: Zhang, email: tony@tust.edu.cn Wang, wn929@tust.edu.cn Keywords: vascular smooth muscle...
To investigate the association between low-carbohydrate-diet (LCD) score and cognitive performance based on a nationally representative sample aged ≥ 60 years from National Health Nutrition Examination Survey (NHANES) database.This cross-sectional study included 2,537 eligible older adults NHANES database 2011-2014. The Consortium to Establish Registry for Alzheimer's Disease (CERAD) word learning subtest, Animal Fluency Test (AFT), Digit Symbol Substitution (DSST) were used assess...
Modern perioperative guidelines encourage drinking oral carbohydrates 2 h before management. Nevertheless, research on the safety of preoperative carbohydrate drinks, particularly in extremely elderly patients is lacking. We aimed to evaluate drinks surgery (≥ 80 years) using gastric ultrasonography.
Although many miRNAs are reported to be involved in tumor formation and progression, the effect of miR-219a-5p on breast cancer metastasis is not well-known. The aim this study investigate migratory ability epithelial-mesenchymal transition (EMT) cells. First, was found highly expressed low-invasive MCF-7 cells, but lowly high-invasive MDA-MB-231 Wound scratch assay transwell showed that inhibited also suppressed cellular EMT, confirmed by suppressing expression mesenchymal markers vimentin...
Gestational diabetes mellitus (GDM) is a situation where glucose intolerance found in pregnant women without previous diagnosis of diabetes. The role Kruppel-like factor 9 (KLF9) has not been investigated GDM, which constituted the aim our study. HTR8/SVneo cells were induced by high (HG) and mice treated with streptozocin (STZ) to establish GDM model
Purpose: To explore the benefits of ultrasound-guided intermittent thoracic paravertebral block (TPVB) combined with intravenous analgesia (PCIA) in alleviating postoperative nausea and vomiting (PONV) during video-assisted surgery (VATS).Patients Methods: 120 patients lung carcinoma undergoing VATS were included divided into three groups: group S (single TPVB+PCIA), I (intermittent P (PCIA).The patients' NRS scores, hydromorphone hydrochloride consumption, intramuscular injection...
Women who develop diabetes during pregnancy are at higher risk of preterm birth. Here, we identified differentially expressed proteins (DEPs) in the serum umbilical cord blood samples obtained from neonates delivered by women with gestational to provide therapeutic targets for clinical drug development.Umbilical was collected after delivery and healthy without diabetes. DEPs were using liquid chromatography-tandem mass spectrometry. Gene Ontology (GO), cluster analysis Kyoto Encyclopedia...
Mucormycosis is a conditionally pathogenic fungal disease with high morbidity that mainly affects patients decreased immunity. Diagnosis relies on the histopathological examination of microorganisms typical structure mucormycetes in tissues and subsequent confirmation via culture. Early detection causative critical to rapidly administer appropriately targeted antibiotics. Metagenomic next-generation sequencing (mNGS) an innovative sensitive technique used identify strains. Here we mNGS...
We report a rare case of acute pulmonary and cerebral complication after transarterial chemoembolization (TACE) for inoperable hepatocellular carcinoma.The involved large tumor hepatic vein invasion.Nonspecific symptoms such as dyspnoea transient consciousness loss developed in the patient, 49-year-old woman, following TACE due to oil embolism.The chest brain conditions this patient improved some supportive therapies nursing interventions.She also subsequently completed other three procedures TACE.
A series of tetraethyl 2,4,8,10-tetramethyl-6,12-diaryl-3,9-dioxahexacyclo[6.4.0.02,7.04,11.05,10]dodecane-1,5,7,11-tetracarboxylates (simplified as 3,9-dioxatetraasteranes) with C2-symmetric structural characteristics were synthesized through the [2 + 2] photocycloaddition diethyl 2,6-dimethyl-4-aryl-4H-pyran-3,5-dicarboxylates. Besides, their anti-human immunodeficiency virus (HIV)-1 activities evaluated by enzyme-linked immunosorbent assay (ELISA) against HIV-1 (IIIB) replication in MT-4...
Elderly epilepsy is the third most common chronic disease that affects metabolism either alone or through antiepileptic drugs (AEDs). Here, we focus on whether neurocognitive profiles in elderly and its treatment are linked to metabolic conditions.Elderly patients with without cognitive impairment (n = 78) 75) were enrolled. C-reactive protein (CRP) markers (triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL-c), low-density (LDL-c), albumin, fasting glucose (Glu)...
Background Joint, skin, oral cavity, and eye lesions are the most common extraintestinal manifestations of ulcerative colitis that can occur before or after its onset. The cases with dermatomyositis (DM) rare. In this study, we report a rare case DM was effectively treated infliximab. Case summary patient 57-year-old female 2-year history DM. admitted to hospital abdominal pain, diarrhea, blood in stool lasting for more than 2 mo. Colonoscopy revealed multiple erosions ulcers entire colon...
In this study, we explored the clinical significance of serum peroxisome proliferator-activated receptor gamma co-activator 1 (PGC-1) alpha levels in diabetes mellitus with myocardial infarction (DMMI) patients and investigated possible mechanism.Serum samples were obtained from DMMI or normal volunteer Baoding First Center Hospital. C57BL/6 mice induced by a single intraperitoneal (i.p.) injection 100 mg/kg STZ (streptozocin) for vivo model. Human cell lines H9C2 cells high glucose medium...
Background We explored clinical characteristics and risk factors for mortality in patients with mental disorders combined severe pneumonia developed predictive models. Methods retrospectively analyzed the data of 161 intensive care unit (ICU) a psychiatric hospital from May 2020 to February 2023, divided them into two groups according whether they died or not, their basic characteristics, laboratory results treatments, etc. patients' deaths using logistics regression, established prediction...
To evaluate the effect of static magnetic fields (SMFs) on insulin secretion and explore mechanisms underlying exposure to SMF-induced in rat insulinoma INS-1 cells.INS-1 cells were exposed a 400 mT SMF for 72 h, proliferation was detected by (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The measured with an enzyme linked immunosorbent assays (ELISA), expression genes real-time PCR, proteins Western blotting.Exposure increased but did not affect cell...
To report a novel splicing mutation in the RPGR gene (encoding retinitis pigmentosa GTPase regulator) three-generation Chinese family with X-linked (XLRP).Comprehensive ophthalmic examinations including best corrected visual acuity, fundus photography, vision field, and pattern-visual evoked potential were performed to identify disease phenotype of six-year-old boy from (proband). Genomic DNA was extracted peripheral blood five available members pedigree. Whole-exome sequencing (WES), Sanger...
This study is to investigate the regulation of Notch1 and Foxp1 by miR-34a in development psoriasis vulgaris. RT-PCR was used compare levels skin lesions 20 patients with vulgaris normal tissues. Immunohistochemistry detect expression 51 vulgaris, which were further compared that 29 control In addition, HaCaT cells, we mimics inhibitors overexpress inhibit miR-34a, respectively, detected mRNA protein Notch1, Foxp1. The level significantly higher than tissues (t=2.192, P<0.05). positive rate...
Introduction Glucagon-like peptide-1 (GLP-1) analogues could induce clinically significant weight loss in obese patients with type 2 diabetes mellitus (T2DM). Beinaglutide is a GLP-1 analogue that fully homologous to human GLP-1. This study aims investigate the clinical efficacy of beinaglutide visceral fat, and blood glucose T2DM obesity. Material methods One hundred seven T2DM, according World Health Organisation’s (WHO) diagnostic criteria, were treated beinaglutide. After 12 weeks,...