A5001767716- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer-related gene regulation
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Cancer-related molecular mechanisms research
- Metal-Organic Frameworks: Synthesis and Applications
- Electrospun Nanofibers in Biomedical Applications
- MicroRNA in disease regulation
- Advanced Photocatalysis Techniques
- Wnt/β-catenin signaling in development and cancer
- TGF-β signaling in diseases
- Surfactants and Colloidal Systems
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- Advanced biosensing and bioanalysis techniques
- Cancer-related Molecular Pathways
- Lung Cancer Treatments and Mutations
- Bone health and osteoporosis research
- Heat shock proteins research
- Bone Metabolism and Diseases
- Curcumin's Biomedical Applications
- Cancer Mechanisms and Therapy
- Magnetism in coordination complexes
- Traditional Chinese Medicine Studies
Chinese PLA General Hospital
2011-2025
Northeast Agricultural University
2018-2025
Shaanxi University of Technology
2020-2024
General Hospital of Shenyang Military Region
2023-2024
Chongqing Normal University
2022-2024
China Electronics Technology Group Corporation
2024
Tianjin Medical University
2024
Second Hospital of Tianjin Medical University
2024
Jiangsu University of Science and Technology
2024
Wuhan University
2024
A rhodamine B derivative 4 containing a highly electron-rich S atom has been synthesized as fluorescence turn-on chemodosimeter for Cu(2+). Following Cu(2+)-promoted ring-opening, redox and hydrolysis reactions, comparable amplifications of absorption signals were observed upon addition Cu(2+); this suggests that effectively avoided the quenching caused by paramagnetic nature Importantly, can selectively recognize Cu(2+) in aqueous media presence other trace metal ions organisms (such...
A MOF-253 supported active Ru carbonyl complex (MOF-253–Ru(CO)<sub>2</sub>Cl<sub>2</sub>) was constructed for photocatalytic CO<sub>2</sub> reduction under visible light irradiation. The performance can be further improved by immobilization of Ru(bpy)<sub>2</sub>Cl<sub>2</sub> as a photosensitizer.
Abstract Efficient osteogenic differentiation and bone formation from mesenchymal stem cells (MSCs) should have clinical applications in treating nonunion fracture healing. MSCs are adherent marrow stromal that can self-renew differentiate into osteogenic, chondrogenic, adipogenic, myogenic lineages. We identified morphogenetic protein 9 (BMP-9) as one of the most BMPs. Here we investigate effect insulin-like growth factor 2 (IGF-2) on BMP-9-induced formation. found endogenous IGF-2...
Circulating miRNAs (microRNAs) are emerging as promising biomarkers for several pathological conditions, and the aim of this study was to investigate feasibility using serum liver pathologies. Real-time qPCR (quantitative PCR)-based TaqMan MicroRNA arrays were first employed profile in pools from patients with HCC (hepatocellular carcinoma) or LC (liver cirrhosis) healthy controls. Five (i.e. miR-885-5p, miR-574-3p, miR-224, miR-215 miR-146a) that up-regulated selected further quantified...
Mesenchymal stem cells (MSCs) are non-hematopoietic with the capacity to differentiate into tissues of both mesenchymal and non-mesenchymal origin.MSCs can osteoblastic, chondrogenic, adipogenic lineages, although recent studies have demonstrated that MSCs also able other including neuronal cardiomyogenic lineages.Since their original isolation from bone marrow, been successfully harvested many tissues.Their ease ex vivo expansion combined immunoprivileged nature has made these popular...
Mesenchymal stem cells (MSCs) are bone marrow stromal that can differentiate into multiple lineages. We previously demonstrated BMP9 is one of the most potent BMPs to induce osteogenic differentiation MSCs. least studied BMPs. Whereas ALK1, ALK5, and/or endoglin have recently been reported as potential type I receptors in endothelial cells, little known about receptor involvement BMP9-induced Here, we conduct a comprehensive analysis functional role seven signaling found expressed However,...
As one of the most common malignancies, colon cancer is initiated by abnormal activation Wnt/β-catenin pathway. Although treatment options have increased for some patients, overall progress has been modest. Thus, there a great need to develop new treatments. We found that bisbenzylisoquinoline alkaloid tetrandrine (TET) exhibits anticancer activity. TET used as calcium channel blocker treat hypertensive and arrhythmic conditions in Chinese medicine. Here, we investigate molecular basis...
Scope The NLRP3 inflammasome responds to various pathogen‐derived factors and danger‐associated molecules, mediating IL‐1β maturation, therefore is involved in multiple inflammatory diseases. Curcumin has been shown possess strong anti‐inflammatory activity, but the underlying mechanism not fully understood. Here, we sought investigate role of curcumin on inhibition mature production via regulation inflammasome. Methods results dramatically inhibited LPS‐primed macrophages triggered by...
Abstract Growth hormone (GH) is usually released by somatotrophs in the anterior pituitary response to GH-releasing and plays an important role skeleton development postnatal growth. However, it unclear if extrapituitary GH exerts any effect on murine multilineage cells (MMCs). MMCs are multipotent progenitors that give rise several lineages, including bone, cartilage, fat. We have identified bone morphogenic protein 9 (BMP9) as one of most osteogenic BMPs regulating a distinct set...
Osteogenic differentiation from mesenchymal progenitor cells (MPCs) are initiated and regulated by a cascade of signaling events. Either Wnt/β-catenin or estrogen pathway has been shown to play an important role in regulating skeletal development maintaining adult tissue homeostasis. Here, we investigate the potential crosstalk synergy these two pathways osteogenic MPCs. We find that activation receptor (ER) estradiol (E2) exogenously expressed ERα MPCs synergistically enhances Wnt3A-induced...
A westernized high-fat diet (HFD) is associated with the development of inflammatory bowel disease (IBD). High level fecal deoxycholic acid (DCA) caused by HFD contributes to colonic injury IBD, however, mechanism concerning initiation response DCA remains unclear. In this study, we sought investigate role and in induction inflammation via promoting NLRP3 inflammasome activation. Here for first time showed that dose-dependently induced activation highly pro-inflammatory cytokine-IL-1β...
Osteosarcoma (OS) is associated with poor prognosis due to its high incidence of metastasis and chemoresistance. It often arises in areas rapid bone growth long bones during the adolescent spurt. Although certain genetic conditions alterations increase risk developing OS, molecular pathogenesis poorly understood. Recently, defects differentiation have been linked cancers, as they are cell proliferation. Treatments overcoming these enable terminal subsequent tumor inhibition. OS development...
It has been reported that ophiopogonin D (OP-D), a steroidal glycoside and an active component extracted from <i>Ophiopogon japonicas</i>, promotes antioxidative protection of the cardiovascular system. However, it is unknown whether OP-D exerts protective effects against doxorubicin (DOX)-induced autophagic cardiomyocyte injury. Here, we demonstrate DOX induced excessive autophagy through generation reactive oxygen species (ROS) in H9c2 cells mouse hearts, which was indicated by significant...
Metastasis is the leading cause of death for gastric carcinoma. An epigenetic biomarker panel predicting carcinoma metastasis could have significant clinical impact on care patients with The main purpose this study to characterize methylation differences between carcinomas and without metastasis.
A series of silica-gel-supported sulfur-capped PAMAM dendrimers (SiO2-G0-MITC–SiO2-G2.0-MITC) were synthesized and used for the adsorption Hg(II) from aqueous solution. The optimum pH was found to be 6. Adsorption kinetics indicated that equilibrium can approached in about 220 min capacity increased with increasing generation dendrimers. process controlled by film diffusion follow a pseudo-second-order model. isotherms fitted well Langmuir isotherm model, take place chemical mechanism....
Abstract Zinc‐ion capacitors (ZICs), as a new type of electrochemical energy storage (EES) device with great development prospects, have garnered considerable attention because they integrate the advantages high‐energy zinc‐ion batteries and high‐power supercapacitors to meet people's demand for low‐cost, long‐term durability high safety. Nevertheless, investigation ZICs remains in its infancy, many problems need be resolved. In particular, challenge caused by finite ion adsorption capacity...
The Wnt pathway plays a critical role in development and differentiation of many tissues, such as the gut, hair follicles, bone. Increasing evidence indicates that Wnts may function key regulators osteogenic mesenchymal stem cells bone formation. Conversely, aberrant signaling is associated with pathologies. For example, genetic alterations lead to osteoporosis osteopenia, while inactivating mutations inhibitors result hyperostotic skeleton increased mineral density. Hyperparathyroidism...