A5100689126- Mesenchymal stem cell research
- Advanced Multi-Objective Optimization Algorithms
- Nuclear Receptors and Signaling
- Metaheuristic Optimization Algorithms Research
- MicroRNA in disease regulation
- Cancer Cells and Metastasis
- Immune Cell Function and Interaction
- Multiple Sclerosis Research Studies
- T-cell and Retrovirus Studies
- Computational Drug Discovery Methods
- Water Quality Monitoring and Analysis
- Vector-Borne Animal Diseases
- Immune cells in cancer
- Parkinson's Disease Mechanisms and Treatments
- Cancer, Lipids, and Metabolism
- Neurogenesis and neuroplasticity mechanisms
- Immunotherapy and Immune Responses
- Tissue Engineering and Regenerative Medicine
- Optimal Experimental Design Methods
- Animal Disease Management and Epidemiology
- T-cell and B-cell Immunology
- Chronic Lymphocytic Leukemia Research
- Chronic Kidney Disease and Diabetes
- IL-33, ST2, and ILC Pathways
- Adenosine and Purinergic Signaling
University of Yamanashi
2024
Union Hospital
2022-2024
Jilin University
2014-2024
Harbin University of Commerce
2024
Union Hospital
2018-2023
Qingdao University
2020-2022
Qingdao Municipal Hospital
2020-2022
Nanjing Normal University
2014
Rutgers, The State University of New Jersey
2006-2009
Johnson University
2009
It has been reported that ophiopogonin D (OP-D), a steroidal glycoside and an active component extracted from <i>Ophiopogon japonicas</i>, promotes antioxidative protection of the cardiovascular system. However, it is unknown whether OP-D exerts protective effects against doxorubicin (DOX)-induced autophagic cardiomyocyte injury. Here, we demonstrate DOX induced excessive autophagy through generation reactive oxygen species (ROS) in H9c2 cells mouse hearts, which was indicated by significant...
Acute kidney injury (AKI) induced by cisplatin (cis-AKI) involves indicators such as inflammation and oxidative stress (OS) in proximal tubules, although its underlying mechanisms remain largely unknown so far. Exploration of the molecular cisplatin-induced AKI is great significance for prevention also preventing progression into chronic disease (CKD) or end-stage renal (ESRD). OS ferroptosis are mutually causal; they finally lead to regulatory cell death accumulation reactive oxygen species...
AbstractDifferentiation therapy for cancer is a developing treatment modality that based on the anti-proliferative effects associated with differentiation of malignant cells. 1,25-dihydroxyvitamin D3 (1,25D) and its analogs are currently being evaluated clinically, alone or in combination other agents, several neoplastic diseases, but their usefulness as single agents may be limited by enhancement cell survival some types exposed to 1,25D. In this study we role AKT signaling pathway, known...
BACKGROUND:Microglia participate in mediating neuroinflammation which P2X7R triggered by adenosine triphosphate has a critical effect after spinal cord injury. However, how the of microglia regulate injury is still unclear.The aim this study was to explore mechanism P2X7 receptor regulates NLRP3 inflammasome-dependent inflammation. MATERIAL AND METHODS:Sixt rats were divided into 5 groups: sham group, model BzATP an A-438079 and BzATP+CY-09 group. Rats group only subjected laminectomy other...
Cordycepin has good antitumor activity, but its clinical application is limited due to the easy deamination of N6 in structure. In this study, a large lipolysis group was introduced at cordycepin improve problem, derivatives (3a–4c) were synthesized, and biological evaluation compounds studied. vitro activity against MCF7 cells, HepG2 cells SGC-7901 evaluated by MTT assay. results, compound 4a showed most obvious inhibitory effect on with an IC50 value 27.57 ± 0.52 μM, which much lower than...
Abstract Mesenchymal stem cells (MSCs) are potent immunoregulators and have shown clinical utility in suppressing immunity. MSC function is modulated by cytokines, since inflammatory such as interferon-γ (IFNγ) concomitant with tumor necrosis factor-α (TNFα), induce their immunoregulatory capability. Here, we show that IFNγ TNFα act synergistically to high levels of expression interleukin-6 (IL-6) several other immune-related molecules MSCs vitro. We further found that, while either or alone...
Immunotherapy of tumors plays a pivotal role in the current treatment cancer. While interleukin 2 (IL-2) demonstrated its efficacy as an immunotherapeutic drug early days, short blood circulation time poses challenges maintaining effective therapeutic concentrations. Additionally, IL-2’s activation regulatory T cells can counteract anti-cancer effects. Therefore, primary goal this study was to formulate IL-2-carrying nanoparticles via boron-nitrogen coordination between methoxy poly...
The objective is to search potential therapeutic drugs for Parkinson’s disease based on data mining and bioinformatics analysis providing new ideas research studies “new application of conventional drugs.” Method differential gene candidates were obtained genes PD brain tissue, original analysis, crossover, pathway enrichment protein interaction, through drug-gene relationship. Result . 250 common from 3 studies, 31 interaction. 10 such as metformin hydrochloride directly or indirectly...
Aim and Objective: Effective components the mechanism of action Zhichan powder for treatment Parkinson's disease were researched at a systematic level. Materials Methods: Screening active in was conducted using Traditional Chinese Medicine Systems Pharmacology database, medicine-target-disease network established with computational pharmacology. Results: By pharmacology methods, we identified 18 major through screening, indicating connection between chemical this Parkinson’s disease-related...
Cervical cancer stem cells (CCSCs), a small part of tumor population, are one the important reasons for metastasis and recurrence cervical cancer. Targeting CCSCs may be an effective way to eliminate tumors. Salinomycin (Sal) has been proved anticancer drug in many studies, especially (CSCs). However, cytotoxicity salinomycin limits its further research as drug. High-density lipoprotein (HDL) nanoparticles excellent carrier, which can reduce toxicity Sal, have certain targeting effect...
Unlike T cells restricted by major histocompatibility complex (MHC) class Ia or II molecules, MHC I-like molecules demonstrate properties of both innate and adaptive immunity are therefore considered innate-like lymphocytes (ILLs). ILLs believed to have immunoregulatory functions, but their roles in autoimmunity defense against infections remain elusive. To study the ILLs, we generated mice expressing only crossing CIITA-/- with Kb-/-Db-/- mice. Surprisingly, these developed a...
Interleukin-2 (IL-2) used in multiple sclerosis (MS) therapy modulates the balance between regulatory T (Treg) cells and effector (Teff) cells. However, off-target activation of Teff by IL-2 limits its clinical application. Therefore, a rapidly prepared immunoswitch nanomodulator termed aT-IL2C NPs was developed, which specifically recognized Treg with high TIGIT expression thanks to presence an anti-TIGIT IL-2/JES6-1 complex (IL2C) being delivered but not low expression. Then, IL2C released...
Multi- or many-objective evolutionary algorithm- s(MOEAs), especially the decomposition-based MOEAs have been widely concerned in recent years. The emphasize convergence and diversity a simple model made great success dealing with theoretical practical multi- optimization problems. In this paper, we focus on update strategies of decomposition- based MOEAs, their criteria for comparing solutions. Three disadvantages local several existing solutions are analyzed discussed. And global loop...
Abstract Background At present, estimated glomerular filtration rate (eGFR) remains the most frequently utilized parameter in evaluation of kidney injury severity. Numerous equations have been formulated based on serum creatinine (Scr) or cystatin C (Cysc) levels. However, there is a lack consensus regarding efficacy these assessing eGFR, particularly for elderly individuals China. This study aimed to evaluate applicability MDRD, MDRDc, CKD-EPI series, BIS1, and FAS within Chinese...