A5062329356- Noise Effects and Management
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiomyopathy and Myosin Studies
- Cancer-related molecular mechanisms research
- Vagus Nerve Stimulation Research
- Vehicle Noise and Vibration Control
- Cardiovascular Health and Disease Prevention
- Pesticide Exposure and Toxicity
- Extracellular vesicles in disease
- Air Quality and Health Impacts
- Acute Ischemic Stroke Management
- Tryptophan and brain disorders
- Blood Pressure and Hypertension Studies
- Neurological Disorders and Treatments
- Body Composition Measurement Techniques
- Sleep and Wakefulness Research
- Health disparities and outcomes
- Sleep and related disorders
- Lipoproteins and Cardiovascular Health
- Cerebrovascular and Carotid Artery Diseases
- Hearing Loss and Rehabilitation
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Receptor Mechanisms and Signaling
Jinan University
2021-2024
Erasmus University Rotterdam
2024
Zhongda Hospital Southeast University
2016-2022
Shanxi Datong University
2021
Southeast University
2019
Xijing Hospital
2018
Xinjiang Medical University
2018
First Affiliated Hospital of Xinjiang Medical University
2018
Air Force Medical University
2018
Background: Stroke is a leading cause of adult disability that can severely compromise the quality life patients, yet no effective medication currently exists to accelerate rehabilitation. A variety circular RNA (circRNA) molecules are known function in ischemic brain injury. Lentivirus-based expression systems have been widely used basic studies circRNAs, but safety issues with such delivery limited exploration potential therapeutic roles for circRNAs. Methods: Circular SCMH1 (circSCMH1)...
Background and Purpose— Circular RNAs (CircRNAs) show promise as stroke biomarkers because of their participation in various pathophysiological processes associated with acute ischemic (AIS) stability peripheral blood. Methods— A circRNA microarray was used to identify differentially expressed circulating circRNAs a discovery cohort (3 versus 3). Validation (36 36) replication (200 100) were performed independent cohorts by quantitative polymerase chain reaction. Platelets, lymphocytes,...
Long noncoding RNAs (lncRNAs) have been highlighted to be involved in the pathological process of ischemic stroke (IS). The purpose present study was investigate expression profile lncRNAs peripheral blood mononuclear cells (PBMCs) acute IS patients and explore their utility as biomarkers IS. Distinctive patterns PBMC were identified by an lncRNA microarray individual quantitative real-time PCR (qRT-PCR) four independent sets for 206 IS, 179 healthy controls (HCs), 55 with transient attack...
The effect of the triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C) ratio (TG/HDL-C) on clinical outcomes acute ischaemic stroke (AIS) patients is unclear. This study sought determine whether TG/HDL-C in AIS associated with worse at 3 months.Acute who were admitted from 2011 2014 enrolled this study. TG, total (TC), HDL-C and low-density (LDL-C) collected admission. Three end-points defined according modified Rankin scale (mRS) score months after symptom onset (excellent...
Inflammation is integral to the pathophysiology of ischemic stroke and a prime target for development new therapies. The aim present study seek out regulatory mechanism circCDC14A in neuroinflammatory injury tMCAO mice.The expression level peri-infarct cortex plasma mice were detected by qPCR. localization peripheral blood cells explored situ hybridization immunofluorescence colocalization staining. Lentivirus microinjected into lateral ventricular brain or injected tail vein interfere with...
Background and purpose MicroRNAs (miRNAs) have been demonstrated to play crucial roles in the early stage of acute ischaemic stroke (AIS). The this study was investigate expression patterns miRNAs peripheral blood mononuclear cells (PBMCs) from AIS patients further explore related molecular mechanisms stroke‐induced immunodeficiency syndrome (SIDS). Methods miRNA PBMCs were detected by microarray validated quantitative real‐time polymerase chain reaction (qRT‐PCR) healthy controls....
Abstract Background There were a few studies that examined the longitudinal association between living alone and depressive symptoms, vast majority of them conducted in patients with certain diseases, such as heart failure, cancer, glaucoma. This study aimed to examine symptoms large representative older Chinese population. Methods The China Health Retirement Longitudinal Study (CHARLS) data from 2015 2018 used. Living was defined participants who did not live others ever or more than 11...
Stroke-induced immunodeficiency syndrome (SIDS) is regarded as a protective mechanism for secondary inflammatory injury well contributor to infection complications. Although stroke-induced hyperactivation of the sympathetic system proved facilitate SIDS, involved endogenous factors and pathways are largely elusive. In this study, we aim investigate function beta-arrestin-2 (ARRB2) in sympathetic-mediated SIDS.Splenic ARRB2 expression activity were detected after establishing transient models...
Identifying those patients who were at high risk of stroke associated infection (SAI) for preventive antibiotic therapy was imperative patients' benefits, thus improving prediction SAI critical all acute ischemic (AIS) patients. Circular RNA FUNDC1 (circFUNDC1) has been reported to be the diagnosis and prognosis biomarker AIS. Therefore, present study aimed figure out whether circFUNDC1 could potential predictor that help guide treatment. In total, 68 included in study, 26 which had 42...
Abstract Aims This study investigated the association between serum calcium levels and prevalence of T2D using a cross‐sectional Mendelian randomization analysis. Methods Cross‐sectional data were obtained from National Health Nutrition Examination Survey (NHANES) 1999 to 2018. Serum divided into three groups (low, medium high groups) according tertiles. Logistic regression was used estimate prevalence. Instrumental variables for UK Biobank two‐sample MR analysis performed examine causal...
This analysis aims to investigate the association between household pesticide exposure and hypertension risk, determine whether smoking plays a role in this association. We used data from National Health Nutrition Examination Survey (NHANES) for years 1999-2014, including total of 32,309 U.S. adult participants who were 20 or older. Smoking status self-reported. Blood pressure was measured by trained personnel using mercury sphygmomanometer, according standardized protocol. observed an...
Theranostic perfluorocarbon nanoprobes have recently attracted attention due to their fascinating versatility in integrating diagnostics and therapeutics into a single system. Furthermore, although 17β-estradiol (E2) is potential anti-hypertrophic drug, it has severe non-specific adverse effects various organs. Therefore, we developed cardiomyocyte-targeted theranostic achieve concurrent targeted imaging treatment of cardiac hypertrophy.We had successfully synthesized E2-loaded, primary...
Background : Identification of early modifiable factors is crucial to delay or prevent the development cognitive impairment and reduce social economic burden. Objective This study aimed examine longitudinal associations childhood neighborhood quality (CNQ) with risk later-life dysfunction role body mass index (BMI) in this association. Methods A total 8,289 community-dwelling middle-aged elderly population from wave 2011, 2013, 2015 China Health Retirement Longitudinal Study (CHARLS) were...