A5101776262- Chemotherapy-induced cardiotoxicity and mitigation
- Erythropoietin and Anemia Treatment
- GDF15 and Related Biomarkers
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- PARP inhibition in cancer therapy
- Immunotherapy and Immune Responses
- Chronic Lymphocytic Leukemia Research
- Gastric Cancer Management and Outcomes
- CAR-T cell therapy research
- Mitochondrial Function and Pathology
- Head and Neck Surgical Oncology
- Reconstructive Surgery and Microvascular Techniques
- Tracheal and airway disorders
- Head and Neck Cancer Studies
- Lipoproteins and Cardiovascular Health
- Orthopedic Surgery and Rehabilitation
- Acute Ischemic Stroke Management
- Nanowire Synthesis and Applications
- Esophageal Cancer Research and Treatment
- Fungal Biology and Applications
- Bone Metabolism and Diseases
- Mycobacterium research and diagnosis
- Cancer, Hypoxia, and Metabolism
- Chronic Kidney Disease and Diabetes
China Pharmaceutical University
2022-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024-2025
Xiyuan Hospital
2025
Chinese PLA General Hospital
2020-2025
China Academy of Chinese Medical Sciences
2025
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
2022-2024
Shenzhen University
2024
Guangzhou University of Chinese Medicine
2024
Sun Yat-sen Memorial Hospital
2015-2023
Sun Yat-sen University
2015-2023
Abstract Background Postmenopausal osteoporosis (PMOP) is a bone metabolism disorder involving systematic inflammation activation. Blood routine examination easily available in clinical practice and contains abundant information reflecting the level. Thus, it attractive to achieve early diagnosis of PMOP predict osteoporotic fracture risk just based on biomarkers blood examination. Methods A multi‐centric prospective cohort study was designed enrolled postmenopausal women from two...
Long noncoding RNAs (lncRNAs) have been highlighted to be involved in the pathological process of ischemic stroke (IS). The purpose present study was investigate expression profile lncRNAs peripheral blood mononuclear cells (PBMCs) acute IS patients and explore their utility as biomarkers IS. Distinctive patterns PBMC were identified by an lncRNA microarray individual quantitative real-time PCR (qRT-PCR) four independent sets for 206 IS, 179 healthy controls (HCs), 55 with transient attack...
The triglyceride (TG)-to-high-density lipoprotein cholesterol (HDL-C) ratio (TG/HDL-C) is a simple approach to predicting unfavorable outcomes in cardiovascular disease. influence of TG/HDL-C on acute ischemic stroke remains elusive. purpose this study was investigate the precise effect 3-month mortality after (AIS). Patients with AIS were enrolled present from 2011 2017. A total 1459 participants single city China divided into retrospective training and prospective test cohorts. Medical...
Abstract Mitochondrial topoisomerase IB (TOP1MT) is a nuclear-encoded topoisomerase, exclusively localized to mitochondria, which resolves topological stress generated during mtDNA replication and transcription. Here, we report that TOP1MT overexpressed in cancer tissues demonstrate deficiency attenuates tumor growth human mouse models of colon liver cancer. Due their mitochondrial dysfunction, TOP1MT-KO cells become addicted glycolysis, limits synthetic building blocks energy supply...
The limited efficacy of chimeric antigen receptor (CAR) T-cell therapies with solid malignancies prompted us to test whether epigenetic therapy could enhance the antitumor activity B7-H3.CAR T cells several cancer types.We evaluated B7-H3 expression in many human and normal tissue samples. combinatorial deacetylase inhibitor SAHA types potential underlying mechanisms were characterized vitro ex vivo experiments.B7-H3 is expressed most tumor samples tested, but exhibits a restricted tissues....
We report a living cell-target responsive accessibility profiling (LC-TRAP) approach to identify the targetome of silibinin (SIL), well-established hepatoprotective natural product (NP), in HepG2 cells. Proteins showing changes, probed by covalent lysine labeling reagents and leveraged multiplexed quantitative proteomics, following administration SIL cells were assigned as potential targets. Among targetome, ACSL4, an enzyme essential for ferroptosis induction, might be involved effects...
The preservation and enhancement of historical news video archives represent a critical challenge in digital archiving. This paper proposes novel dual-stream approach leveraging modified conditional Generative Adversarial Networks (GANs) for simultaneous audio quality footage. framework incorporates parallel processing pathways restoration, connected through an innovative feature fusion mechanism. architecture introduces several key improvements, including temporal-aware modules, multi-scale...
Background Emerging evidence indicates a potential correlation between remnant cholesterol (RC) and the development of vascular damage hypertension. Nevertheless, precise relationship RC hypertension in relation to renal function remains uncertain. The objective this investigation was employ cohort design evaluate intricate Methods present utilized data from China Health Retirement Longitudinal Study (CHARLS), encompassing total 5,109 participants, for comprehensive analysis examination. Cox...
Obesity is a global health issue. Traditional treatment modalities such as lifestyle modifications, pharmacological interventions, and bariatric surgery often present various limitations. Recently, endoscopic metabolic therapies (EBMTs) have emerged promising minimally invasive approaches for weight management. These reduce gastric volume energy intake, prolong emptying, regulate hormones associated with satiety. This study evaluates purse-string suturing (EGPSS), novel procedure designed to...
The atherogenic index of plasma (AIP), a novel composite lipid index, is closely linked to cardiovascular disease (CVD). However, levels fluctuate dynamically, and it unclear whether there are differences in the association single-timescale, multiple-timescale, or AIP change trajectories with new-onset disease. Hence, aim this study was investigate correlation between different parameters occurrence CVD. Data were derived from China Health Retirement Longitudinal Study (CHARLS) conducted...
Abstract Background To elucidate the mechanism of dysfunction tolerogenic dendritic cells (DCs) is significance. Telomerase involves regulation cell fate and activities. The objective this study to investigate role telomerase reverse transcriptase (TERT) in regulating feature DCs. Methods was assessed DCs, which were collected from patients with allergic rhinitis (AR), healthy control (HC) subjects, mice. RNAs extracted analyzed by RNA sequencing (RNAseq), real-time quantitative RT-PCR,...
Abstract Endoplasmic reticulum (ER) stress‐induced cancer cell apoptosis has become a novel signaling target for the development of therapeutic drugs treatment. Curcumin, dietary phytochemical, exhibits growth‐suppressive activity against cells via multitarget mechanisms. However, low stability and poor pharmacokinetics significantly limit its clinical applications. Thus, we designed synthesized monocarbonyl analog curcumin, 1,5‐bis(2‐methoxyphenyl) penta‐1,4‐dien‐3‐one (B63). This compound...
Pneumonia is a severe inflammatory disease of the lung. Forkhead box protein A2 (FOXA2) has been demonstrated to serve an important regulatory role in various pulmonary diseases; however, FOXA2 pneumonia remains be elucidated. The present study aimed explore functional effects and mechanism pneumonia. An <em>in vitro</em> model was induced using lipopolysaccharide (LPS) WI‑38 cells. mRNA expression levels were determined by reverse transcription‑quantitative PCR western blotting,...
The biogenesis of outer membrane proteins is mediated by the β-barrel assembly machinery (BAM), which a heteropentomeric complex composed five named BamA-E in E. coli. Despite great progress BAM structural analysis, molecular details BAM-mediated processes as well exact function each component during OMP are still not fully understood. To enable distinguishment component, it aim present work to examine and identify effective minimum form coli use well-defined reconstitution strategy based on...