A5101833675- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
- Bone Tumor Diagnosis and Treatments
- Sarcoma Diagnosis and Treatment
- CAR-T cell therapy research
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Cancer Immunotherapy and Biomarkers
- Circular RNAs in diseases
- Tissue Engineering and Regenerative Medicine
- Colorectal Cancer Treatments and Studies
- Medicinal Plant Pharmacodynamics Research
- Infectious Aortic and Vascular Conditions
- Cytokine Signaling Pathways and Interactions
- Aortic aneurysm repair treatments
- Pluripotent Stem Cells Research
- Electrospun Nanofibers in Biomedical Applications
- Cleft Lip and Palate Research
- 14-3-3 protein interactions
- Liver Disease Diagnosis and Treatment
- Mycobacterium research and diagnosis
- Musculoskeletal synovial abnormalities and treatments
- Mesenchymal stem cell research
Second Xiangya Hospital of Central South University
2015-2024
Central South University
2014-2024
Massachusetts General Hospital
2019-2021
Harvard University
2019-2021
First Affiliated Hospital of Xinjiang Medical University
2020
Xinjiang Medical University
2020
Hunan University
2019
Abstract miRNAs that translocate from the nucleus to mitochondria are referred as mitochondrial microRNAs (mitomiR). mitomiRs have been shown modulate translational activity of genome, yet their role in DNA (mtDNA) transcription remains be determined. Here we report mitomiR-2392 regulates chemoresistance tongue squamous cell carcinoma (TSCC) cells by reprogramming metabolism via downregulation oxidative phosphorylation and upregulation glycolysis. These effects were mediated through partial...
Radiotherapy (RT) is a key treatment for prostate cancer. However, RT resistance can contribute to failure. Prostate cancer stem cells (PCSCs) are radioresistant. We recently found that fractionated irradiation (FIR) upregulates expression of the immune checkpoint B7-H3 (CD276) on PCSCs and bulk in each cell line tested. These findings prompted us investigate whether targeting chimeric antigen receptor (CAR) T cells, which may abrogate function an mediate lysis targeted target RT-resistant
Abstract Purpose: The overall biological roles and clinical significance of most long noncoding RNAs (lncRNA) in chemosensitivity are not fully understood. We investigated the function, mechanism, lncRNA NR_034085, which we termed miRNA processing–related (MPRL), tongue squamous cell carcinoma (TSCC). Experimental Design: LncRNA expression TSCC lines with cisplatin treatment was measured by microarray confirmed tissues. functional MPRL were demonstrated a series vitro vivo experiments....
Abstract Background The current successful clinical use of agents promoting robust anti-tumor immunity in cancer patients warrants noting that radiation therapy (RT) induces immunogenic cell death (ICD) tumor cells, which can generate immune responses. However, breast stem cells (BCSCs) are resistant to RT and alone usually failed mount an response. Methods High aldehyde dehydrogenase activity (ALDH) bright CD44 + /CD24 − /ESA previously shown have BCSC properties, were isolated from human...
The limited efficacy of chimeric antigen receptor (CAR) T-cell therapies with solid malignancies prompted us to test whether epigenetic therapy could enhance the antitumor activity B7-H3.CAR T cells several cancer types.We evaluated B7-H3 expression in many human and normal tissue samples. combinatorial deacetylase inhibitor SAHA types potential underlying mechanisms were characterized vitro ex vivo experiments.B7-H3 is expressed most tumor samples tested, but exhibits a restricted tissues....
Recently, increasing studies suggested that lncRNA SNHG12 was aberrantly expressed in kinds of cancers. However, definite prognostic value remains unclear. We conducted this meta-analysis to evaluate the association between expression level and cancer prognosis. A literature retrieval by searching databases. The performed using Revman 5.2 Stata 12.0 software. Besides, Cancer Genome Atlas dataset analyzed validate results our via Gene Expression Profiling Interactive Analysis. pooled showed...
Abstract Background Reconstruction of hemiglossectomy defects requires careful flap design to avoid adverse functional and aesthetic outcomes. Methods Hemitongue specimens were obtained from minipigs study the three‐dimensional anatomy define anatomic landmarks for precise measurements requirement. The concept developed in animal models was then applied reconstruction clinical practice. Sixty‐one patients randomly enrolled into following two groups: a “five‐point eight‐line segment” (FIPELS)...
Various factors play crucial roles in aneurysm development and prognosis. Macrophages have recently emerged as a major research focus. Despite the numerous studies on role function of macrophages pathogenesis, no bibliometric analyses focused this topic.
Aims: Chondrosarcoma (CS) is a high-morbidity, relatively common bone malignancy without well-established biomarkers. The proteins EAAT1, DHFR, and fetuin-A have been investigated in many cancers, but their specific relationship to CS has not reported. present study examined expression the clinicopathological significance of these pathogenesis, progression, prognosis. Methods: protein levels 80 25 chondroma specimens were measured by immunohistochemistry related histological clinical factors...
Abstract Background We aimed to unbiasedly map the genetic mutation profile of HNSC and CESC associated with HPV status in Chinese population (SYSU‐cohort) compare them Western (TCGA‐cohort). Methods Fifty‐one patients (SYSU‐HNSC) 38 (SYSU‐CESC) were enrolled this study. Genomic alterations examined, was produced using YuanSuTM450 gene panel (OrigiMed, Shanghai, China). The altered genes inferred compared from TCGA cohorts. Results Compared TCGA‐HNSC cohort, FGFR3 identified as a novel...
Chondrosarcoma is the second most common malignant bone tumor. Current therapies remain ineffective, resulting in poor prognoses. Biomarkers for chondrosarcoma and predictors of its prognosis have not been established. Mental health-related proteins associated with pathogenesis, progression, many cancers, but their association has reported. In this study, expression clinicopathological significance mental DAXX, DRD3, DISC1 tissue samples were examined, over an 84-months follow-up period....
An amendment to this paper has been published and can be accessed via the original article.
Objective: To understand the hepatitis C virus (HCV) genotype distribution characteristics in Xinjiang region. Methods: 6462 cases with chronic HCV infection that were treated at First Affiliated Hospital of Medical University from January 2013 to September 2018 selected, and repeated testers excluded. A total 4773 genotypes efficiently included. PCR-reverse dot hybridization method was used retrospectively analyze distribution. χ (2) test or F-test for intergroup comparison. P < 0.05...
To investigate the eff ect of icaritin on proliferation and apoptosis in rat chondrocytes to provide new theory for osteochondropathy treatment.Icaritin (with a purity 99%) at different concentrations (0, 4, 8, 16, 32, 64 μmol/L) was incubated with time. The cell assayed by MTT fl ow cytometry, respectively.Compared control group, increased groups 4 or 8 μmol/L (P<0.05), whereas decreased 32 compared group (P<0.05); ratio obviously lower than that aft er incubation 24 h 48 h. Beyond μmol/L,...
Abstract Background: Recently, dysregulation of lncRNA SNHG12 has been determined in kinds cancers. However, definite prognostic value remains unclear. We conducted this meta-analysis to evaluate the association between expression levels and caner prognosis.Methods: A literature retrieval was by searching databases. The clinicopathological parameters performed using Revman 5.2 Stata 12.0 software. Besides, Cancer Genome Atlas dataset analyzed validate results our via Gene Expression...