A5101477345- CAR-T cell therapy research
- Topic Modeling
- Immunotherapy and Immune Responses
- RNA modifications and cancer
- Biomedical Text Mining and Ontologies
- Cancer-related molecular mechanisms research
- Natural Language Processing Techniques
- Nanowire Synthesis and Applications
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Immune Cell Function and Interaction
- Immune cells in cancer
- Advanced biosensing and bioanalysis techniques
- Fibroblast Growth Factor Research
- Lung Cancer Treatments and Mutations
- Epigenetics and DNA Methylation
- Virus-based gene therapy research
- Cancer-related gene regulation
- Infant Nutrition and Health
- Peptidase Inhibition and Analysis
- Microtubule and mitosis dynamics
- MicroRNA in disease regulation
- DNA and Nucleic Acid Chemistry
- Cell Adhesion Molecules Research
- Machine Learning and Algorithms
Taiyuan University of Technology
2025
Ningbo No. 2 Hospital
2025
Huaqiao University
2025
Zhejiang University of Science and Technology
2023-2025
Hebei Normal University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Xiyuan Hospital
2024
Fudan University Shanghai Cancer Center
2024
Sun Yat-sen Memorial Hospital
2020-2023
Sun Yat-sen University
2016-2023
Abstract Recent studies have shown that extracellular microRNAs are not only potential biomarkers but also involved in cell interactions to regulate the intercommunication between cancer cells and their microenvironments various types of malignancies. In this study, we isolated exosomes from nasopharyngeal carcinoma ( NPC ) lines patient sera (T‐ EXOs ), or control NP69 healthy donor HD‐EXOs ). We found miR ‐24‐3p was markedly enriched T‐ as compared with ; serum exosomal level correlated...
Abstract In addition to the role of programmed cell death ligand 1 (PD-L1) in facilitating tumour cells escape from immune surveillance, it is considered as a crucial effector transducing intrinsic signals promote development. Our previous study has pointed out that PD-L1 promotes non-small lung cancer (NSCLC) proliferation, but mechanism remains elusive. Here we first demonstrated expression levels were positively correlated with p-MerTK patient samples and NSCLC lines. addition, knockdown...
Acquired epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) resistance limits the long-term clinical efficacy of kinase-targeting drugs. Although most mechanisms acquired EGFR-TKI have been revealed, mechanism ~ 15% cases has not yet elucidated. Cell viability was analysed using Counting Kit-8 (CCK-8) assay. Proteome profiler array analysis performed to find proteins contributing resistance. Secreted OPN detected by ELISA. Immunohistochemical conducted detect expression...
The limited efficacy of chimeric antigen receptor (CAR) T-cell therapies with solid malignancies prompted us to test whether epigenetic therapy could enhance the antitumor activity B7-H3.CAR T cells several cancer types.We evaluated B7-H3 expression in many human and normal tissue samples. combinatorial deacetylase inhibitor SAHA types potential underlying mechanisms were characterized vitro ex vivo experiments.B7-H3 is expressed most tumor samples tested, but exhibits a restricted tissues....
Tetraspanins CD151, a transmembrane 4 superfamily protein, has been identified participating in the initiation of variety cancers. However, precise function CD151 non-small cell lung cancer (NSCLC) remains unclear. Here, we addressed pro-tumoral role NSCLC by targeting EGFR/ErbB2 which favors tumor proliferation, migration and invasion.First, mRNA expression levels tissues lines were measured RT-PCR. Meanwhile, its associated proteins analyzed western blotting. The samples paired adjacent...
Immune cell heterogenicity is known to determine the therapeutic response cancer progression. Neoadjuvant chemoimmunotherapy (NACI) has shown clinical benefits in some patients with advanced head and neck squamous carcinoma (HNSCC), but underlying mechanism behind this unknown. The efficacy of NACI needs be potentiated by identifying accurate biomarkers predict responses. Here, we attempted identify molecules predicting HNSCC.We performed combined single-cell RNA sequencing (scRNA-seq)...
The expansion of myeloid-derived suppressor cells (MDSCs) correlates with tumorigenesis in colorectal cancer (CRC). Here, we found a significant association between CD33+ MDSC number and Yes-associated protein 1 (YAP1) phosphatase tensin homologue (PTEN) levels CRC patients (P < 0·05). Moreover, the MDSCs, YAP1 PTEN were identified as predictors for prognosis Notably, MDSCs an independent survival predictor through Cox model analysis. In vitro data determined that expression CRC-derived cell...
Chimeric antigen receptor (CAR)-based immunotherapy has shown great potential for the treatment of both hematopoietic malignancies and solid tumors. Nevertheless, multiple obstacles still block development CAR-based in clinical setting. In this study, we aimed to summarize research landscape highlight front lines trends field. Literature published from 2001 2021 was searched Web Science Core Collection database. Full records cited references all documents were extracted screened....
Bladder cancer (BCa) stands out as a prevalent and highly lethal malignancy worldwide. Chemoresistance significantly contributes to recurrence progression. Traditional Tumor Node Metastasis (TNM) stage molecular subtypes often fail promptly identify treatment preferences based on sensitivity.
ABSTRACT Bolt support mechanisms represent a key technique to the surrounding rock in coal mines. In deep engineering applications, bolt‐supported structure of roadway under high bearing stress may fail dynamic loads such as those blasting vibrations and earthquake motion. this study, uniaxial compression tests were conducted on steel bar reinforced investigate rockbolt performance loading. The deformation specimen surface was recorded during test. strengths failure modes bolted samples...
A water-soluble polysaccharide extracted from Gastrodia elata was chemically modified to generate acetylated and carboxymethylated derivatives. Thourshe conditions for the two modification methods were optimized through single factor response surface analyses. The acetylation 3.4 mL of acetic anhydride, a reaction temperature 63.4 °C, duration 4 h. For carboxymethylation, optimal parameters 2.2 g chloroacetic acid, 62.3 °C NaOH concentration mol/L. results chemical analysis Fourier transform...
<title>Abstract</title> The impact failure response characteristics of rock specimens and bolted under different dynamic loads were studied by Split Hopkinson pressure bar (SHPB). By comparing the time history laws incident energy, reflection transmission energy dissipation in process combination with strain bolts rock, mechanism loading was obtained. design idea surrounding bolt support a roadway proposed. results show that ① When velocity bullet is 7.1 m/s, 8.1 m/s 8.9 "EPRD"...
Abstract Disintegrin-metalloproteinase 15(ADAM15), a member of disintegrin metalloproteinases (ADAMs), plays important roles in various cancer types. However, the underlying ADAM15 functioning lung is still unclear. In present study, we find that regulates epidermal growth factor receptor/focal adhesion kinase (EGFR/FAK) signalling pathway by interactions with integrins. Integrin αV involved ADAM15-mediated FAK signalling. Further, and CD151 were co-expressed, presence affected integrin...
Background Although many studies have defined mechanisms of resistance to EGFR‐TKIs, acquired remains the major limitation monotherapy with EGFR‐TKIs. Methods Cell viability was analyzed using a Counting Kit‐8 (CCK‐8) assay. EGFR T790M mutation sequenced on HiSeq 4000 platform. mRNAs from HCC827 and gefitinib‐resistant (GR) cells were by genome analyzer‐based deep sequencing. The effect anlotinib apoptosis cell cycle arrest GR detected fluorescence‐activated sorting (FACS) analysis. A mouse...
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide.SMAD family member 2 (SMAD2) a key element downstream transforming growth factor beta (TGF-β) signaling pathway that regulates metastasis by promoting epithelial-mesenchyme transition (EMT).MicroRNA miR-486-5p tumor suppressor in NSCLC progression.However, it remains unclear whether implicated TGF-β and EMT NSCLC.In present study, high expression SMAD2 mRNA was detected tissues lines, associated with...
Abstract Lung cancer is the primary cause of death among patients in China, which nonsmall cell lung (NSCLC) makes up great majority. Hence, it imperative to identify biomarkers and mechanisms involved NSCLC oncogenesis. Our present research found that KIAA1199 expression was significantly increased closely related proliferation, motility, poor prognosis. We demonstrated knockdown reduced growth motility vitro whereas overexpression had opposite effect. Inhibition suppressed tumor mouse...
It has been revealed from microarray data analysis that long intergenic non‑coding RNA 02454 (LINC02454) is highly expressed in papillary thyroid cancer (PTC). The aim of the present study was to explore potential role LINC02454 tumorigenesis PTC. mRNA expression levels were assessed using Cancer Genome Atlas (TCGA) and GSE66783 cohort cancer, validated reverse transcription‑quantitative PCR 104 patients with PTC recruited study. association between clinicopathological features also...
Abstract Background The Ecotropic viral integration site 5 (EVI5), an important protein in regulating cell cycle, cytokinesis and cellular membrane traffic, functions as a stabilizing factor maintaining anaphase-promoting complex/cyclosome (APC/C) inhibitor Emi1 S/G2 phase. However, the mechanism by which EVI5 promotes malignant transformation of non-small lung cancer (NSCLC) remains unknown. In present study, we addressed role NSCLC tumor growth, migration invasion. Methods expression...
To investigate whether TCF7+ T cells constitute an important factor to improve the existing postoperative prediction model for patients with oral squamous cell carcinoma.TCF7+ were detected in tissues of 167 OSCC by multiplex immunofluorescence. The percentage was transformed into a dichotomous variable, combined clinicopathological data patients, and then subjected univariate multivariate analyses. derived independent predictors incorporated risk models analyze their relationship prognosis...