A5100771095- CAR-T cell therapy research
- Cancer Mechanisms and Therapy
- Immune Cell Function and Interaction
- Cardiovascular Health and Disease Prevention
- Integrated Circuits and Semiconductor Failure Analysis
- Head and Neck Cancer Studies
- Immunotherapy and Immune Responses
- Nanowire Synthesis and Applications
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease Diagnosis and Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pregnancy and preeclampsia studies
- Lymphoma Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Cardiovascular Issues in Pregnancy
- Melanoma and MAPK Pathways
- Circular RNAs in diseases
- Galectins and Cancer Biology
- Heart rate and cardiovascular health
- Autoimmune and Inflammatory Disorders Research
- Endometrial and Cervical Cancer Treatments
- Thyroid Disorders and Treatments
- Birth, Development, and Health
- Colorectal Cancer Treatments and Studies
- Advancements in Semiconductor Devices and Circuit Design
Anhui Medical University
2020-2025
National Chung Cheng University
2024
Second Hospital of Anhui Medical University
2020-2024
Sun Yat-sen Memorial Hospital
2021-2024
Sun Yat-sen University
2021-2024
Chinese PLA General Hospital
2024
Beijing Hospital
2024
Nankai University
2023-2024
Guangdong Academy of Medical Sciences
2024
Guangdong Provincial People's Hospital
2024
Abstract CD19-specific chimeric antigen receptor T cell (CD19 CAR T) therapy has shown high remission rates in patients with refractory/relapsed B-cell acute lymphoblastic leukemia (r/r B-ALL). However, the long-term outcome and factors that influence efficacy need further exploration. Here we report of 51 r/r B-ALL from a non-randomized, Phase II clinical trial (ClinicalTrials.gov number: NCT02735291). The primary shows overall rate (complete or without incomplete hematologic recovery) is...
The limited efficacy of chimeric antigen receptor (CAR) T-cell therapies with solid malignancies prompted us to test whether epigenetic therapy could enhance the antitumor activity B7-H3.CAR T cells several cancer types.We evaluated B7-H3 expression in many human and normal tissue samples. combinatorial deacetylase inhibitor SAHA types potential underlying mechanisms were characterized vitro ex vivo experiments.B7-H3 is expressed most tumor samples tested, but exhibits a restricted tissues....
With the rapid progress of systematic therapy for hepatocellular carcinoma (HCC), therapeutic strategies combining hepatic arterial infusion chemotherapy (HAIC) with arised increasing concentrations. However, there have been no review comparing HAIC and its combination in first-line treatment advanced HCC.
Chimeric antigen receptor (CAR)-based immunotherapy has shown great potential for the treatment of both hematopoietic malignancies and solid tumors. Nevertheless, multiple obstacles still block development CAR-based in clinical setting. In this study, we aimed to summarize research landscape highlight front lines trends field. Literature published from 2001 2021 was searched Web Science Core Collection database. Full records cited references all documents were extracted screened....
Abstract Background The purpose of the study was to compare efficacy two novel obesity indices, lipid accumulation product (LAP) and visceral adiposity index (VAI), with traditional indices in predicting early-onset type 2 diabetes (T2DM). Methods In this cross-sectional study, a total 744 participants, including 605 patients newly diagnosed T2DM 139 non-diabetic control subjects, were enrolled from tertiary care hospital Tianjin, China. Participants divided into groups based on their age at...
To investigate the correlation between visceral obesity and pathogenesis of chronic kidney disease (CKD) among non-diabetic individuals, to evaluate potential adiposity index (VAI) as a predictor CKD.From December 2017 March 2018, 1877 participants (male n=699, female n=1208) in southern China were recruited for cross-sectional survey. Males females divided into four groups according gender-specific quartiles VAI scores. A logistic regression model was established analyze CKD.Visceral...
e14569 Background: Circular RNA as emerging technology hasn't been approved of acceptance any IND application. What’s the pharmacokinetics, pharmacodynamics and toxicity study circular drug candidate would be like is still unpublished. Here we provide an exhaustive pre-clinical a novel encoding IL-12sc, immune stimulatory effector. Methods: Here, performed candidate(cmRNA1210) including pharmacodynamics, pharmacology toxicology study. Meanwhile, explored bioactivity cross reactivity...
Substantial studies reveal that tertiary lymphoid structure (TLS) correlate with prognosis and immunotherapy response in various types of cancers. However, the predictive value TLS, specific immune cell subtype within TLS their anti-tumor mechanisms remain unclear.
Abstract Chimeric antigen receptor T‐cell (CAR‐T) therapy has demonstrated remarkable efficacy in treating relapsed/refractory acute B‐cell lymphoblastic leukaemia (R/R B‐ALL). However, a subset of patients does not benefit from CAR‐T therapy. Our study aims to identify predictive indicators and establish model evaluate the feasibility Fifty‐five R/R B‐ALL 22 healthy donors were enrolled. Peripheral blood lymphocyte subsets analysed using flow cytometry. Sensitivity, specificity, accuracy,...
The relationship of tubal sterilization and use an intrauterine device (IUD) to the risk invasive squamous cell cervical cancer was evaluated in a case-control study carried out Shandong, China, from 1989 1991. Patients (cases) were 272 women aged 30-77 years with newly diagnosed Shandong Province Tumor Hospital. Controls 893 randomly selected screened matched cases by age (within 2 years) county. A decrease observed uses IUD, especially long-term users under 33. nonsignificant 33 who had...
Growing evidence has reported that a history of preeclampsia (PE) increases the risk developing cardiovascular disease (CVD). Arterial stiffness plays predictive role in CVD. Previous studies have demonstrated close association between homocysteine (Hcy) level and arterial community-based populations. This study was to assess whether Hcy independently associated with 168 women PE who were analyzed at 5-year follow-up. Brachial-ankle pulse wave velocity (baPWV) measured by an automatic...
Adiponectin protects against the development of albuminuria in rodent experiments and patients with diabetic kidney disease. However, it is not clear whether higher circulating adiponectin levels have same effect pregnancy-induced hypertension (PIH). Urine albumin excretion (UAE) an easy to use test a powerful index for routine management PIH patients. This study aimed investigate relationship between serum total UAE A 156 were enrolled divided into three groups according tertiles. level was...
Relapsed diffuse large B-cell lymphoma (DLBCL) is a disease with poor prognosis. Recent clinical trials results showed chimeric antigen receptor (CAR) T cell therapy has promising role in treating relapsed DLBCL. Unfortunately, patients extranodal lesions respond poorly to CAR-T cells administered intravenously. Herein, we evaluated the efficacy and safety of new treatment strategy cells, combining intravenous infusion local injection DLBCL patient lesions. The achieved durable remission...
Abstract In 2008, sorafenib became the first approved systemic therapeutic agent for advanced HCC. Although its pharmacological efficacy has been established, reimbursement such a new, high‐cost drug, as well physicians' awareness and prescription practice, likewise contribute to clinical effectiveness. We therefore conducted retrospective study using 38 sorafenib‐eligible, HCC patients when was but not yet reimbursed control 216 during era. Study group showed longer survival at 8.2 months...
Obesity and insulin resistance (IR) may be risk factors for thyroid disease, but there is no clinical-based consensus on this topic. Therefore, study aims to evaluate the associations between triglyceride-glucose index (TyG) its derivatives Hashimoto thyroiditis (HT) in type 2 diabetes mellitus (T2DM) patients, explore relationships central obesity indicators HT provide a reliable basis early prevention of HT. A total 1071 T2DM patients aged ≥ 20 years were selected from tertiary hospital...