Reactive oxygen species (ROS) play important roles in follicular development and survival. Granulosa cell death is associated with increased ROS, but the mechanism of granulosa induced by ROS not clear. In order to define molecular link between death, COV434, human tumor cells, were treated H2O2. Compared control H2O2 a dose- time-dependent manner. an increase Bax, Bak Puma, decrease anti-apoptotic molecules such as Bcl-2, Bcl-xL Mcl-1. Both knockdown Puma overexpression could inhibit...

Abstract The development of potassium‐ion battery (PIB) electrode materials is critical for promoting their use in next‐generation energy storage systems. Although metal–organic frameworks (MOFs) are appealing materials, performance PIBs remains unsatisfactory. low K + adsorption (Δ E a ) on the saturated coordination MOFs can explain limited capacity. Herein, MXene‐derived MOF nodes (NMD‐MOF) unlocked and used as anodes PIB. NMD‐MOF anode exhibits substantially increased capacity (250 mA h...

Abstract The electroreduction of nitrate (NO 3 RR) to ammonia (NH ) provides a promising solution enable environmental remediation caused by ‐containing waste and also allows for energy‐saving NH generation. Adsorption *NO 2 intermediate may be strengthened decrease byproducts (e.g., favor the eight‐electron NO RR into . In this work, copper‐incorporated O‐vacancy containing Ti C MXene (Cu@Ti O v is reported, which cooperatively inhibits production facilitates hydrogenation, leading...

Objectives Statins and calcium channel blockers have been proven beneficial toward improvement of endothelial function. The aim this study was to compare the effect combination therapy statin blocker with solo treatment in patients cardiac syndrome X. Methods results Sixty-eight X were divided randomly into three groups: fluvastatin (40 mg/day, n=23), diltiazem (90 n=22), mg/day) n=23). At end 90 days, coronary flow reserve improved groups (fluvastatin-treated group: 23.2%; diltiazem-treated...

Graphene has yet to be mass produced, so practical fast-charging lithium-ion battery (LIB) prototypes based on graphene are scarce. suffers from long in-plane and reluctant in-depth lithium diffusion due its defect-free atomic arrangement, resulting in unsatisfactory rate performance as LIB anodes. In this work, combinatorial flash joule heating ball milling treatment implemented enable gram-scale production of seconds (known graphene, FG) ordered-range modulation architectures. Following...

Abstract The objective of this study was to evaluate the effects combination therapy with photodynamic (PDT) and a novel antiangiogenic regimen using monoclonal antibodies against both vascular endothelial growth factor receptors (VEGFR)‐1 (MF1) VEGFR‐2 (DC101) on intracranial glioblastoma xenografts in nude mice. Nude mice bearing intracerebral U87 were treated PDT (MF1 DC101) either alone or combination, while those left untreated served as tumor controls. Tumor volume animal survival time...

Blood pressure levels and the prevalence of hypertension are related to adiposity. We evaluated relationship adiposity blood in normotensive untreated hypertensive African Americans-an ethnic group with a high obesity.Outpatient measurements were obtained 1,858 1,998 subjects (44% untreated) residing Milwaukee. The pressure-adiposity was also analyzed non-Hispanic black (n = 908) white 2182) National Health Nutrition Examination Survey (NHANES) participants.In Milwaukee subjects, body mass...

Immunoglobulin-like transcript 4 (ILT4) is an inhibitory molecule involved in immune response and has recently been identified to be strongly inducible by IL-10. The aim of the present study was examine associations ILT4 expression with clinicopathological characteristics IL-10 primary ductal lobular breast cancer. We studied cancer cell lines, 117 tumor tissues 97 metastatic lymph nodes from patients reverse transcription-polymerase chain reaction, western blot or immunohistochemistry...

4-Vinylcyclohexene diepoxide (VCD), an industrial occupational health hazard chemical associated with premature ovarian insufficiency (POI) and reproductive failure. Recently, investigators have paid increasing attention on VCD model of menopause recapitulates the natural, physiological transition through perimenopause to menopause. The current study sought examining mechanisms follicular loss exploring effect systems outside ovaries. In this study, 28 days female SD rats were injected (160...

Abstract Objective: The Menopause-Specific Quality-of-Life (MENQOL) questionnaire was developed as a specific tool to measure the health-related quality-of-life of postmenopausal women. Thus far, Chinese version has not been subjected psychometric assessment with large sample. This study aims evaluate validity and reliability MENQOL women in China. Methods: A total 1,137 menopausal symptomatic 491 asymptomatic from eight cities China were recruited using convenience sampling method....

Tea (Camellia L.) falls into the family Theaceae, is a valuable commercial crop, and tea products made from its buds young leaves are favored by consumers all over world. The more common Thea plant Camellia sinensis (C. sinensis), but most important relative, taliensis taliensis), also utilized locals in area of cultivation to manufacture tea. In this investigation, C. (DL) (QJZ) were characterized terms their agronomic traits, physicochemical indices, metabolomics, transcriptomics. leaf DL...

Premature ovarian insufficiency (POI), a condition impacting women under 40, is rising globally, posing significant risks to fertility, bone health, and cardiovascular function. Conventional hormone replacement therapy (HRT) alleviates symptoms but fails restore Our prior studies have demonstrated that the Huyang Yangkun (HYYK) formula effectively supports menstrual cycle frequency menopause-related in POI patients. This study aims evaluate efficacy safety of HYYK formula, traditional...

<title>Abstract</title> <bold>Background</bold>: The multi-campus hospitals have become increasingly prevalent in China over the past few decades, however, how to improve quality of service and better develop remain insufficiently understood literature. Patient satisfaction is an important indicator measurement quality. This study aimed analyze status patient its key influencing factors, order provide relevant reference on homogeneous management differentiated strategies aiming at consistent...

Abstract Catalytic performance of methanol oxidation reaction (MOR) on transition metal carbides (TMCs) can be enhanced by doping fluorine. Herein, we report the successful synthesis reduced graphene oxide (rGO) supported fluorine doped NbC nanoparticles (NbFxC NP/rGO) as efficient non-noble electrocatalyst for MOR in both acidic and basic solutions. As result, NbFxC NP/rGO exhibits onset potentials 0.33 V vs. SCE -0.30 Hg/HgO medium alkaline medium, respectively. It is even superior to that...

Huyang Yangkun Formula (HYF), based on Yin and Yang principles, is effective in treating Premature Ovarian Insufficiency (POI) enhancing reproduction, but its mechanism needs to be clarified. This study investigates HYF's impact ovarian follicles development via GABA/GnRH neuron regulation. The chemical components of water extract HYF were analyzed by combining the ultra-high performance liquid chromatography coupled with Q-Exactive mass spectrum analysis (UHPLC-QE-MS). Female SD rats...

Huyang Yangkun Formula (HYF) is a Chinese herbal remedy used for premature ovarian insufficiency (POI), though its active ingredients and mechanisms are not well understood.This study aims to identify HYF's chemical components investigate mechanism in treating POI. Using UHPLC-QE Focus HRMS, profiling quantification were conducted. The therapeutic effects target validation of HYF examined using POI rat model, human granulosa cells (COV434), network pharmacology. Molecular docking was predict...

Huyang Yangkun Formula (HYF) has been prescribed for premature ovarian insufficiency (POI) decades in the clinical setting. Little is known regarding its underlying molecular mechanism. This study was conducted to elucidate possible mechanism of protective potential HYF against POI induced by industrial chemical 4-vinylcyclohexene diepoxide (VCD) rats. Quality control via HPLC and UPLC-MS. Female rats were injected with VCD (160 mg/kg) daily 15 days. Then, 1.35 g/kg (low dose) or 0.235 (high...

Huyang Yangkun Formula(HYF) is a traditional Chinese medicine formula based on the theory of Yin and Yang. It could consolidate Qi Yang, adjust balance blood. has shown clinical efficacy for patients with Premature Ovarian Insufficiency(POI).Aim to access effect (HYF) premature ovarian insufficiency rat model explores mechanism related aquaporins(AQPs) apoptosis.Female SD rats were injected 4-vinylcyclonhexenediepoxide(VCD, 160 mg/kg/day) 15 days. Then, HYF (0.297 g/kg)/estradiol valerate...

Huyang Yangkun Formula (HYYKF) was developed based on theory of traditional Chinese medicine as well clinical experience and used to improve ovarian function premature insufficiency (POI) patients. Transplantation embryonic stem cells (ESCs) has great potential in improving POI, studies have confirmed that promoted the treatment effect ESCs. In present study, we compared combining HYYKF ESCs, single ESCs intervention POI mice explore combination function.C57BL/6 were create a model by 15-day...