A5031940613- T-cell and Retrovirus Studies
- Lymphoma Diagnosis and Treatment
- RNA modifications and cancer
- Cancer-related gene regulation
- Sarcoma Diagnosis and Treatment
- Connective Tissue Growth Factor Research
- Cancer-related molecular mechanisms research
- TGF-β signaling in diseases
- DNA Repair Mechanisms
- Estrogen and related hormone effects
- Mitochondrial Function and Pathology
- Liver Disease Diagnosis and Treatment
- Chronic Disease Management Strategies
- Endometriosis Research and Treatment
- Epigenetics and DNA Methylation
- Testicular diseases and treatments
- Angiogenesis and VEGF in Cancer
- Head and Neck Cancer Studies
- Viral-associated cancers and disorders
- Circular RNAs in diseases
- Immune Cell Function and Interaction
- ATP Synthase and ATPases Research
- Endometrial and Cervical Cancer Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Reproductive tract infections research
Sun Yat-sen University
2012-2023
Sun Yat-sen Memorial Hospital
2012-2023
Sichuan University
2006-2017
West China Hospital of Sichuan University
2006-2017
Second Affiliated Hospital of Guangzhou Medical University
2009
Guangzhou Medical University
2009
Purpose To investigate the prognostic value of N6-methyladenosine (m6A)-, 5-methylcytosine (m5C)-, and N1-methyladenosine (m1A)-related genes in cervical cancer (CESC) predicting immunotherapy response.Methods We downloaded mRNA expression profiles, clinical data, m6A, m5C, m1A-related from public databases, subjected them to serial bioinformatics analysis sample validation.Results Differential revealed 106 methylation-related differential (MEDs), including 44 differentially downregulated 62...
// Song Fan 1,2,* , Bodu Liu 1,3,* Lijuan Sun Xiao-bin Lv 1,4,* Zhaoyu Lin Weixiong Chen 2 Weiliang Qionglan Tang 5 Youyuan Wang Yuxiong Su 6 Shaowen Jin 7 Daming Zhang Jianglong Zhong Yilin Li 8 Bin Wen 9 10 Pu Yang 11 Zhou Qixiang Liang Xing Yu Yinghua Zhu 4 Pengnan Hu 3 Junjun Chu Wei Huang Yuhuan Feng Hongzhuang Peng 12 Qihong Erwei 1,3 Jinsong 1,2 1 Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Yat-Sen Memorial Hospital, University, Guangzhou,...
It has been well established that tumor-associated macrophages (TAMs) play a tumor promoting role in endometrial endometrioid adenocarcinoma (EEC). But the association with TAMs and sex hormone receptor expression, progression of precancerous lesions EEC little reported.We used immunohistochemistry to examine expression CD68, CD34, vascular endothelial growth factor (VEGF), estrogen (ER) progesterone (PR) 95 cases EEC, as 35 hyperplasia (including 15 atypical hyperplasia, 10 complex simple...
We conducted a prospective study to test the association between three amino acid substitution polymorphismic variants of DNA repair genes, XRCC1 (Arg194Trp), XRCC1(Arg280His) and (Arg399Gln), clinical outcome ovarian cancer patients undergoing adjuvant chemotherapy.195 with primary advanced treated by chemotherapy were included in our study. All followed-up from Jan. 2007 2012. Genotyping polymorphisms was TaqMan Gene Expression assays.The 194 Trp/Trp genotype conferred significant risk...
It has been well established that the aberrant activation of Wnt/β-catenin signal correlates to endometrial endometrioid adenocarcinoma (EEC). As an effector mediated antiapoptotic signal, role Wnt-induced secreted protein-1 (WISP-1) in EEC still remains unclear.We used immunohistochemistry and quantitative real-time RT-PCR examine expression WISP-1, estrogen receptor (ER) progesterone (PR) 86 cases EEC, with 20 hyperplasia, proliferative endometrium secretory as control group. We also...
Abstract Purpose: Adults with T-cell lymphoblastic lymphoma (T-LBL) generally benefit from treatment acute leukemia (ALL)-like regimens, but approximately 40% will relapse after such treatment. We evaluated the value of CpG methylation in predicting for adults T-LBL treated ALL-like regimens. Experimental Design: A total 549 27 medical centers were included analysis. Using Illumina Methylation 850K Beadchip, 44 relapse-related CpGs identified 49 samples by two algorithms: least absolute...
Objective: Connections between chronic inflammation and tumor development progression are now generally accepted. Recent evidence indicates that hepatitis B is associated with several types of cancer, but whether endometrial carcinoma (EC) included has not been reported. Methods: We analyzed HBV serum marker status in 398 patients comparing them to 788 control women undergoing health examination. Results: The total prevalence HBsAg tested positive cancer group was significantly higher than...
So far, ovarian cancer has still been the most lethal gynecological malignancy.The chemotherapy and targeted medication are mainstay for recurrent treatment.About 70% of advanced-stage cases will relapse.Ascites-derived organoid is a pre-clinical model precise prediction therapeutic effectiveness cancer: it can be used to assess drug sensitivity, guide individualized treatment, improve advanced stage as well patient' survival prognosis.Until now, there no report concerning establishment out...
To investigate the expression of CD44v3 and vascular endothelial growth factor-C (VEGF-C) their relationship with lymph node metastasis in squamous cell carcinomas (SCC) uterine cervix.Expression VEGF-C was analyzed 109 cases cervical SCC by immunohistochemistry (IHC). The between patient age, histological differentiation, formation tumor emboli lymphoid vessels, metastasis, FIGO staging, TNM classification.Expression rates for both were 43.1% SCC. cells positive immunohistochemical staining...
Surgical treatment of carotid body tumors remains challenging, and this study evaluated the outcomes tumor pseudoaneurysm after blunt dissection tumors.Six cases were classified as Shamblin groups I, II, III (1, 1, 4 cases, respectively). Tumor size ranged from 2 × 3 to 5 6 (median, 3.7 4.7) cm. Two patients underwent tumor, two ligation external artery had common artery-internal artificial vascular reconstruction.No perioperative mortality or stroke occurred. The mean blood loss was 455...
To evaluate the safety and feasibility of combined procedures: HIFU with systemic MTX followed by ultrasound-guided curettage or hysteroscopic resection while treating placenta accreta (PA).This study included 21 patients diagnosed retained PA marked vascularity after abortion delivery from July 2015 to December 2017. Patients high serum β-hCG level (≥100 mIU/mL) received + treatment for 3 days ones low (<100 only USgHIFU before resection. All had completed follow-up data. The were evaluated...
Cigarette smoking causes a variety of adverse human health effects, including lung cancer. The molecular events associated with smoke-induced carcinogenesis are thought to be related in part autophagy. Beclin 1 is an important autophagy-related protein involved cell death and survival.The purpose this investigation was determine the beclin its association cigarette smoke mutation epidermal growth factor receptor (EGFR) non-small cancer (NSCLC).Our study included 108 cases who were admitted...
Abstract Aim Recurrent vulvovaginal candidiasis (RVVC) is a chronic, difficult to treat vaginal infection, caused by Candida species, which affects women of all ages and ethnic social background. Most RVVC studies use animal models, there still lack observation on human tissue samples effective therapy reduce recurrence. Materials Methods We observed CD163 + macrophages NLRP3 expression immunohistochemistry, also investigated bacteria fungi co‐invasion fluorescence in situ hybridization from...
Ocular toxicity is an uncommon complication of cytotoxic chemotherapy. Bilateral blindness with secondary retinitis pigmentosa (RP) following docetaxel and platinum combination chemotherapy at the recommended dose extremely rare. The present study reports a case advanced small-cell carcinoma (SCC) endometrium in patient diabetes mellitus type 2. suffered from RP sharp decline vision after fourth course postoperative Unfortunately, developed bilateral another reduced dose. No tumor recurrence...
Pregnancies in hemodialysis patients are uncommon and difficult to study. Although the chance of a successful pregnancy parturition women has increased over years, it still remains extremely low with high maternal fetal mortality morbidity rate. We reported case 22-year-old Chinese female uremic stage chronic renal failure undergoing maintenance (three sessions week) for 6 years. At 22nd gestational week, she was diagnosed as pregnant by ultrasound, started an enhanced routine (Five week)....