A5025478034- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Dermatologic Treatments and Research
- Neonatal Respiratory Health Research
- Metabolomics and Mass Spectrometry Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Asthma and respiratory diseases
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Pediatric health and respiratory diseases
- interferon and immune responses
- melanin and skin pigmentation
- Facial Rejuvenation and Surgery Techniques
- Genomics, phytochemicals, and oxidative stress
- Immune cells in cancer
- Dialysis and Renal Disease Management
- Surgical Simulation and Training
- Pneumonia and Respiratory Infections
- Cancer, Lipids, and Metabolism
- Phagocytosis and Immune Regulation
- Inflammasome and immune disorders
- Vestibular and auditory disorders
- Inflammation biomarkers and pathways
- Medical Imaging and Pathology Studies
- Minimally Invasive Surgical Techniques
Second Affiliated Hospital of Zhejiang University
2023-2025
Peking Union Medical College Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Medical Architecture (United Kingdom)
2023
Lanzhou University
2023
Peking University
2016-2020
Peking University Third Hospital
2016-2020
Jinan University
2015
Introduction Baricitinib is a selective inhibitor of Janus kinase (JAK)1 and JAK2, which associated with clinical improvement in non-severe COVID-19 patients. But severe patients, the effectiveness baricitinib still controversial. Methods A propensity score-matched retrospective study was conducted to evaluate patients requiring invasive mechanical ventilation (IMV). Results total number 48 treated were included, assigned control group by score matching. The mean ages high both (baricitinib...
Abstract Purpose To examine the effect of diabetes, duration and blood glucose on speech-, low/mid-, high-frequency hearing loss. Methods In this cross-sectional study, 2821 participants aged 20–87 years in China National Health Survey were included. Diabetes was defined as valid fasting (FBG) ≥ 7.0 mmol/L, a self-reported history diabetes or use anti-diabetic medications. Speech-(500, 1000, 2000, 4000 Hz), low/mid- (500, 1000 2000 (4000, 6000, 8000 Hz) loss pure tone average responding...
Abstract Biomarkers for the progression of lung function in COPD are currently scarce. Plasma fetuin-B (FETUB) was identified by iTRAQ-based proteomics and verified ELISA another group. Information regarding acute exacerbation (AE) collected a one-year follow-up programme. FETUB concentrations (1652 ± 427 ng/ml) were greater patients than controls (1237 77 ng/ml). The GOLD II (1762 ng/ml), III (1650 375 IV (1800 451 groups those (1257 414 I (1345 391 ROCs indicated that distinguished from...
Metabolomics is an emerging science that can inform pathogenic mechanisms behind clinical phenotypes in COPD. We aimed to understand disturbances the serum metabolome associated with respiratory outcomes ever-smokers from SPIROMICS cohort. measured 27 metabolites, mostly amino acids, by 1H-nuclear magnetic resonance spectroscopy 157 white and without tested association between log-transformed metabolite concentrations one-year incidence of exacerbations after adjusting for age, sex, current...
Chronic obstructive pulmonary disease (COPD) is a systemic condition that too complex to be assessed by lung function alone. Metabolomics has the potential help understand mechanistic underpinnings contribute COPD pathogenesis. Since blood metabolomics may affected sex and body mass index (BMI), aim of this study was determine metabolomic variability in male smokers with without who have narrow BMI range. We compared quantitative proton nuclear magnetic resonance acquired serum Chinese Han...
The role of airway microbiota in COPD is highly debated. Symptomology assessment vital for the management clinically stable patients; however, link between symp toms and microbiome currently unknown.The present study aimed to evaluate relationship among patients.We conducted pyrosequencing bacterial 16S rRNA using induced sputum samples a Han Chinese cohort that included 40 patients 19 healthy controls.Alterations community composition core bacte rial taxa (Neisseria subflava, etc.) were...
Gestational choriocarcinoma ended with a successful parturition is extremely rare, especially in cases where multiple metastases occurred. A 29-year-old Chinese primigravida was admitted vaginal bleeding at 32+2 gestational week, and diagnosed vaginal, pulmonary, cerebral metastasis after pathological, imaging examination. At 33+1 healthy infant delivered by cesarean section. Although no evidence of or any other forms trophoblastic diseases found the placenta uterine curettages, patient...
The study aimed to determine the relationship between throat microbiome and COPD. Sixty-five Chinese males (n=20, smokers without COPD; n=45 with COPD) were included. Nonmetric multidimensional scaling indicated differences of COPD controls, but no difference was observed patients differing degrees lung function or disease severity. Rarefaction analyses suggested that operational taxonomic units (OTUs, species-level) richness decreased in dominant taxa controls similar, proportions...
Abstract: Short-term exposure to major air pollutants can increase the risk of acute exacerbation in chronic obstructive pulmonary disease (COPD) patients. However, evidence on mechanism COPD (AECOPD) caused by is still limited. A total 78 patients with stable and 58 healthy controls were recruited Peking University Third Hospital China from December 2014 January 2015. The correlation lag effect over 7 days (lag1– 7) 6 clinical symptoms inflammatory markers induced sputum analyzed. PM 2.5 ,...
Abstract: Biomarkers for the management of chronic obstructive pulmonary disease (COPD) are limited. The aim this study was to explore new plasma biomarkers in patients with COPD. Thyroxine-binding globulin (THBG) initially identified by proteomics a discovery panel and subsequently verified enzyme-linked immunosorbent assay another verification 1-year follow-up. THBG levels were elevated COPD (9.2±2.3 µg/mL) compared those controls (6.6±2.0 µg/mL). Receiver operating characteristic curves...
Increased levels of cytosolic DNA in lung tissues play an important role acute injury. However, the detailed mechanisms involved remain elusive. Here, we found that cyclic GMP-AMP synthase (cGAS, a sensor) expression was increased airway epithelium response to DNA. Conditional deletion epithelial cGAS exacerbated injury mice, knockdown augmented LPS-induced production interleukin (IL)-6 and IL-8. Mechanically, phosphorylated CREB (cAMP element-binding protein), directly interacted with via...
Pregnancies in hemodialysis patients are uncommon and difficult to study. Although the chance of a successful pregnancy parturition women has increased over years, it still remains extremely low with high maternal fetal mortality morbidity rate. We reported case 22-year-old Chinese female uremic stage chronic renal failure undergoing maintenance (three sessions week) for 6 years. At 22nd gestational week, she was diagnosed as pregnant by ultrasound, started an enhanced routine (Five week)....
<b>Background:</b> Little is known about the role of metabolome in COPD pathogenesis. <b>Aims:</b> To identify metabolic alterations associated with airflow obstruction smokers. <b>Methods:</b> We analyzed serum samples 157 smokers by quantitative nuclear magnetic resonance (NMR) spectroscopy. Airflow (post-bronchodilator FEV1/FVC < 0.7) was staged according to GOLD guidelines. 0 defined as post-bronchodilator > 0.7 and FEV1 80% predicted. tested associations between metabolite...
Matrix operations are widely available in various engineering and scientific computing applications; however, the calculation efficiency depends on input data density. These cannot complete using only one inner/outer product method. Meanwhile, most of current computational accelerator architectures use synchronous clock circuits. As technology approaches its limit scale circuit increases, disadvantage circuits becomes more obvious. Clock fail to meet very low power requirements specific...
Abstract Introduction: Baricitinib is a selective inhibitor of Janus kinase (JAK)1 and JAK2, which associated with clinical improvement in non-severe COVID-19 patients. But severe patients, the efficacy baricitinib still controversial. Methods: A propensity score-matched retrospective study was conducted to evaluate patients requiring invasive mechanical ventilation (IMV). Results: total number 46 treated were included, 44 assigned control group by score matching. The mean ages high both...
During severe infection-induced acute respiratory distress syndrome, invading microorganisms can cause damage to lung epithelium and promote the release of cytosolic DNA. However, detailed mechanism injury induced by increased DNA from airway remains elusive. To address this question, epithelial cyclic GMP-AMP synthase (cGAS) was deleted in lipopolysaccharide(LPS)-induced mouse model as well human bronchial (HBE) cells. We observed that LPS triggered activate cGAS. Conditional deletion cGAS...
Objective To investigate the changes of serum biomarkers in chronic obstructive pulmonary disease (COPD) and their role airflow limitation. Methods Forty-one patients with COPD were selected as group 35 healthy smokers control group.We quantified levels surfactant protein D(SP-D), matrix metalloproteinase 2, 3, 9(MMP-2, 9), CXC chemokine ligand 10 (CXCL10), Clara cell 16 (CC16), soluble receptor for advanced glycation end products (sRAGE) function. Results The level MMP-2 stable...