A5100602916- Immune Cell Function and Interaction
- Parasites and Host Interactions
- RNA modifications and cancer
- Immune responses and vaccinations
- Kruppel-like factors research
- interferon and immune responses
- T-cell and B-cell Immunology
- HIV Research and Treatment
- Asthma and respiratory diseases
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer-related molecular mechanisms research
- Immunodeficiency and Autoimmune Disorders
- Immune cells in cancer
- Angiogenesis and VEGF in Cancer
- Pediatric health and respiratory diseases
- Pluripotent Stem Cells Research
- Inflammasome and immune disorders
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- Cytomegalovirus and herpesvirus research
- Endoplasmic Reticulum Stress and Disease
- Mechanisms of cancer metastasis
- Peptidase Inhibition and Analysis
Shanxi Medical University
2024
Central South University
2018-2024
Shanxi Academy of Medical Sciences
2024
Hebei Medical University
2023
Fourth Hospital of Hebei Medical University
2023
Second Affiliated Hospital of Zhejiang University
2012-2023
University of South China
2023
Xi'an Jiaotong University
2021-2022
Shanghai Institute of Materia Medica
2022
Chinese Academy of Sciences
2022
Oncogenic transcription factor forkhead box M1 (FoxM1)-related clinicopathologic characteristics and prognosis of patients with pancreatic ductal adenocarcinoma (PDA) have not been identified. Our aim studying FoxM1 expression level survival rate PDA is to determine whether a valuable prognostic predictor for patients.Expressional levels mRNA protein in paired cancer lesions adjacent noncancerous tissues were examined by reverse transcription-polymerase chain reaction Western blotting. was...
ABSTRACT Interferon (IFN) signaling is crucial for antiviral immunity. While type I IFN mediated by STAT1, STAT2, and IRF9, II requires only STAT1. Here, we studied the roles of these factors in host response to systemic infection with lymphocytic choriomeningitis virus (LCMV). In wild-type (WT) mice lacking either STAT2 or LCMV was nonlethal, cleared established persistence (STAT2 knockout [KO] IRF9 KO). However, case STAT1 KO mice, lethal accompanied severe multiorgan immune pathology,...
Necroptosis, a form of programmed necrosis, is involved in the pathologic process several kinds pulmonary diseases. However, role necroptosis particulate matter (PM)-induced injury remains unclear. The objective this study to investigate involvement pathogenesis PM-induced toxic effects inflammation and mucus hyperproduction, both vitro vivo.PM was administered into human bronchial epithelial (HBE) cells or mouse airways, inflammatory response production were assessed. mRNA expressions IL6,...
Significance In many malignancies, resistance to targeted therapy emerges rapidly and leads disease progression mortality. Here, we show that trident cold atmospheric plasma (Tri-CAP), a reactive oxygen species–producing gas discharge, simultaneously blocks three cancer survival pathways, including deregulated redox balance, glycolysis, proliferative signaling, in mouse cell line model of therapy-resistant chronic myeloid leukemia (CML). This activity high-rate apoptotic death these CML...
Glycolytic metabolism enzymes have been implicated in the immunometabolism field through changes metabolic status. PGK1 is a catalytic enzyme glycolytic pathway. Here, we set up high-throughput screen platform to identify inhibitors. DC-PGKI an ATP-competitive inhibitor of with affinity Kd = 99.08 nmol/L. stabilizes vitro and vivo, suppresses both activity kinase function PGK1. In addition, unveils that regulates production IL-1β IL-6 LPS-stimulated macrophages. Mechanistically, inhibition...
Staphylococcus aureus infections exert a tremendous burden on the health-care system, and threat of drug-resistant strains continues to grow. The bacteriolytic enzyme lysostaphin is potent antistaphylococcal agent with proven efficacy against both drug-sensitive strains; however, enzyme's own bacterial origins cause undesirable immunogenicity pose barrier clinical translation. Here, we deimmunized using computationally guided process that optimizes sets mutations delete immunogenic T cell...
Ozone is a common environmental air pollutant leading to respiratory illness. The mechanisms regulating ozone-induced airway inflammation remain poorly understood. We hypothesize that ozone-triggered inflammasome activation and interleukin (IL)-1 production regulate neutrophilic through IL-17A. Pulmonary was induced by extended (72 h) low-dose (0.7 ppm) exposure ozone. IL-1 receptor 1 (Il1r1)(-/-), Il17a(-/-) mice the caspase-1 inhibitor acetyl-YVAD-chloromethylketone (Ac-YVAD-cmk) were used...
Abstract Background Nm23‐H1 gene has been found to be an inhibitor of tumor metastasis in lung cancer. MicroRNAs (miRNAs) play key roles through multiple signaling pathways. This study explored whether the nm23‐H1 could inhibit invasion and cancer cells by regulating miRNA‐660‐5p targets. Methods Quantitative real‐time PCR (qRT‐PCR) western blots were used measure expression miR‐660‐5p various human cell lines. Cell counting kit‐8 (CCK‐8), wound‐healing transwell assay carried out assess...
ABSTRACT Plague is one of the most dangerous diseases and caused by Yersinia pestis . Effective vaccine development requires understanding immune protective mechanisms against bacterium in humans. In this study, humoral memory cellular responses plague patients ( n = 65) recovered from Y. infection during past 16 years were investigated using a protein microarray an enzyme-linked immunosorbent spot assay (ELISpot). The seroprevalence to F1 antigen all 78.5%. infected more than decade ago,...
Introduction: Bronchial epithelial cell death and airway inflammation induced by cigarette smoke (CS) have been involved in the pathogenesis of COPD. GRP78, belonging to heat shock protein 70 family, has implicated inflammation, while little is known about its roles Here, we demonstrate that GRP78 regulates CS-induced necroptosis injury bronchial cells. Materials methods: markers were examined human (HBE) line, primary mouse tracheal cells, lungs. siRNA targeting gene inhibitor used....
Interleukin (IL)-18, which belongs to the IL-1 superfamily of cytokines, is a known interferon-gamma (IFN-γ)-inducing factor. Since IFN-γ plays an essential role in anticancer immunity mediated through cytotoxic T cells, IL-18 may also contribute function immunosurveillance. The aim study was examine association with outcomes patients breast cancer.Serum levels were determined at baseline 270 operated for cancer, and relapse-free survival (RFS) compared between IL-18-high -low groups....
The Plk1-interacting checkpoint helicase (PICH) protein localizes to ultrafine anaphase DNA bridges in mitosis along with a complex of repair proteins. Previous studies show PICH deficiency-induced embryonic lethality mice. However, the function that is required suppress PICH-deficient mammals remains be determined. clinical suggest link between deficiency and onset acquired aplastic anemia. Here, using Pich knock-out (KO) mouse models, authors provide evidence for mechanistic defective...
LP-BM5 retrovirus induces a complex disease featuring an acquired immunodeficiency syndrome termed murine AIDS (MAIDS) in susceptible strains of mice, such as C57BL/6 (B6). CD4 T helper effector cells are required for MAIDS induction and progression viral pathogenesis. CD8 not needed pathogenesis, but rather, essential protection from resistant strains, BALB/c. We have discovered immunodominant cytolytic lymphocyte (CTL) epitope encoded previously unrecognized retroviral alternative (+1...
Adenoviruses (Ad) are commonly used as vectors for gene therapy and/or vaccine delivery. Recombinant Ad being tested vaccines many pathogens. We have made a surprising observation that peptides derived from various hepatitis C virus (HCV) antigens contain extensive regions of homology with multiple adenovirus proteins, and conclusively demonstrate vector can induce robust, heterologous cellular humoral immune responses against HCV antigens. Intriguingly, the induction this cross-reactive...
Abstract Fetal growth restriction (FGR) is a condition in which newborn fails to achieve his or her prospective hereditary potential. This associated with high mortality, second only that premature birth. FGR maternal, fetal, and placental abnormalities. Although the placenta considered be an important organ for supplying nutrition fetal growth, research on limited, treatment through remains challenging, as neither proper uterine intervention nor its pathogenesis have been fully elucidated....
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