A5044896063- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Molecular Junctions and Nanostructures
- Antioxidant Activity and Oxidative Stress
- Virus-based gene therapy research
- Quantum Dots Synthesis And Properties
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- Plasma Applications and Diagnostics
- Microbial Community Ecology and Physiology
- Catalytic Processes in Materials Science
- RNA modifications and cancer
- Obstructive Sleep Apnea Research
- Nanofabrication and Lithography Techniques
- Ocular Surface and Contact Lens
- Ubiquitin and proteasome pathways
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related Molecular Pathways
- Chemical Looping and Thermochemical Processes
- Cancer, Lipids, and Metabolism
- Non-Invasive Vital Sign Monitoring
- Corneal Surgery and Treatments
- Epigenetics and DNA Methylation
- Thermochemical Biomass Conversion Processes
- Genetic factors in colorectal cancer
Ocean University of China
2023-2025
People's Hospital of Cangzhou
2024
Shandong University
2024
Shanghai Institute of Materia Medica
2021-2024
Chinese Academy of Sciences
2021-2024
Shandong University of Traditional Chinese Medicine
2024
Tonghua Normal University
2024
Shenyang Aerospace University
2023-2024
ShanghaiTech University
2021-2023
University of Chinese Academy of Sciences
2021-2023
Gelatin–epigallocatechin gallate nanoparticles with hyaluronic acid decoration as eye drops can treat rabbit dry-eye syndrome effectively via inflammatory relief Hsin-Yi Huang,1,2,* Ming-Chen Wang,2,* Zhi-Yu Chen,1 Wen-Ying Chiu,1 Ko-Hua Chen,3,4 I-Chan Lin,4,5 Wei-Chung Vivian Yang,6 Chi-Chang Wu,7 Ching-Li Tseng1,8,9 1Graduate Institute of Biomedical Materials and Tissue Engineering, College Taipei Medical University, City, Taiwan; 2Department Chung Yuan Christian Taoyuan 3Department...
An intratumoral hypoxic microenvironment is frequently observed in solid tumors, including breast cancer. Lutein, a plant-derived compound and non-vitamin A carotenoid, has been demonstrated to possess multiple protective properties anti-inflammation, anti-oxidative stress antitumor effects. The main objective of the present research was elucidate involvement lutein production reactive oxygen species (ROS) under hypoxia, activation hairy enhancer split 1 (HES1), proliferation, invasion...
The translocation of YAP from the cytoplasm to nucleus is critical for its activation and plays a key role in tumor progression. However, precise molecular mechanisms governing nuclear import are not fully understood. In this study, we have uncovered crucial SOX9 YAP. promotes by direct interaction. Importantly, identified that binding between Asp-125 Arg-124 essential SOX9-YAP interaction subsequent entry Additionally, discovered novel asymmetrical dimethylation at (YAP-R124me2a) catalyzed...
Though lutein can inhibit cancer cell proliferation via alleviating oxidative injury, the molecular mechanisms of involvement in NrF2/antioxidant response element (ARE) and NF-κB pathways remain poorly understood.MTT, flow cytometry, quantitative real-time PCR (qRT-PCR) western blot assays were performed.After treatment with lutein, breast was significantly decreased a dose-dependent manner. Lutein induced nuclear translocation protein expression NrF2, improved cellular antioxidant enzymes...
In castration-resistant prostate cancer (CRPC), clinical response to androgen receptor (AR) antagonists is limited mainly due AR-variants expression and restored AR signaling. The metabolite spermine most abundant in it decreases as progresses, but its functions remain poorly understood. Here, we show inhibits full-length (AR-FL) splice variant 7 (AR-V7) signaling suppresses CRPC cell proliferation by directly binding inhibiting protein arginine methyltransferase PRMT1. Spermine reduces...
Glycolytic metabolism enzymes have been implicated in the immunometabolism field through changes metabolic status. PGK1 is a catalytic enzyme glycolytic pathway. Here, we set up high-throughput screen platform to identify inhibitors. DC-PGKI an ATP-competitive inhibitor of with affinity Kd = 99.08 nmol/L. stabilizes vitro and vivo, suppresses both activity kinase function PGK1. In addition, unveils that regulates production IL-1β IL-6 LPS-stimulated macrophages. Mechanistically, inhibition...
Abstract In the era of intensity-modulated radiotherapy (IMRT), it is important to analyse prognostic value deficient mismatch repair (dMMR) in nasopharyngeal carcinoma (NPC). this study, pretreatment biopsies 69 patients with stage II–IVa NPC, expression levels MMR proteins, including MLH1, MSH2, MSH6 and PMS2, were assessed by immunohistochemistry (IHC). The median follow-up time was 37.5 months (3.1–87.4 months). 50.7% cases (35/69) showed preserved all 4 which interpreted as proficient...
Biocompatible and temperature-sensitive amphiphilic polymeric micelles comprised of poly(succinimide)- g-poly( N-isopropylacrylamide- co-N, N-dimethylacrylamide) (PSI- g-poly(NIPAAm- co-DMAAm)) were synthesized to use as new drug carriers. The PSI- co-poly(PNIPAAm- co-DMAAm) polymers prepared by nucleophilic opening poly(succinimide) using amino-terminated poly(NIPAAm- co-DMAAm). lower critical solution temperature the copolymer was 40.6℃ higher than normal human body temperature. blank...
Epigenetic therapy has significant potential for cancer treatment. However, few small potent molecules have been identified against DNA or RNA modification regulatory proteins. Current approaches activity detection of DNA/RNA methyltransferases and demethylases are time-consuming labor-intensive, making it difficult to subject them high-throughput screening. Here, we developed a fluorescence polarization-based 'High-Throughput Methyl Reading' (HTMR) assay implement large-scale compound...
Modification of octadecanethiolate self-assembled monolayers on Au by nitrogen−oxygen or argon−oxygen downstream microwave plasma with a low oxygen content (estimated below several percent) has been studied synchrotron-based high-resolution X-ray photoelectron spectroscopy and water contact angle measurements. For both types plasma, the primary processes were found to be loss conformational orientational order oxidation alkyl matrix headgroup−substrate interface. At same time, film...
Despite being one of the most prevalent and fatal types cancer worldwide, biological details esophageal squamous cell carcinoma (ESCC) remain unknown. Recent studies have demonstrated crucial roles long non‑coding RNAs (lncRNAs) in diverse processes including initiation, progression metastasis. The aim present study was to assess expression profile distal‑less homeobox 6 antisense RNA 1 (DLX6‑AS1) ESCC tissues its contributions proliferation, apoptosis invasion. DLX6‑AS1 a series samples...
Mechanisms of plant community assembly at geographical scale are an interesting topic in ecology and biogeography, which great significance for the understanding species coexistence biodiversity conservation. But so far, only a few studies have simultaneously assessed relative roles multiple-scale factors shaping phylogenetic functional structure communities macroecological scale. In this study, we linked modern climate, glacial-interglacial climate change soil properties with shrub...
Synchrotron-based high-resolution photoelectron spectroscopy was applied to study the modification of alkanethiol (AT) self-assembled monolayers on gold and silver substrates by nitrogen−oxygen downstream microwave plasma. Because low density energy ionizing particles, long-lived nitrogen oxygen radicals provided major impact plasma treatment. The treatment resulted in massive damage disordering initially well-ordered chemically homogeneous AT films. most pronounced processes are complete...
Synchrotron-based high-resolution photoelectron spectroscopy was applied to study the modification of self-assembled monolayers (SAMs) 4'-methyl-1,1'-biphenyl-4-thiols (BPT) on (111) gold and silver substrates by a nitrogen−oxygen downstream microwave plasma attachment acrylic acid plasma-modified SAMs. The treatment resulted in massive damage disordering BPT films, with extent character being noticeably different for BPT/Au BPT/Ag. Whereas profound desorption entire moieties complete...
Noroviruses (NoVs) are increasingly recognized as the leading cause of acute non-bacterial gastroenteritis worldwide. To screen for NoV-specific monoclonal antibodies (mAbs) with wide spectrum binding activities that could be used development NoV-related detection reagents, we immunized mice a combination virus like particles (VLPs) derived from eight different genotypes (two genogroup I and six II), which two (GI.7 GII.2) were newly produced VLPs. Indirect enzyme-linked immunosorbent assay...