A5032357571- Cancer-related Molecular Pathways
- Retinoids in leukemia and cellular processes
- Viral Infections and Vectors
- Natural product bioactivities and synthesis
- Pectus Deformity Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Synthesis of Organic Compounds
- RNA modifications and cancer
- HIV/AIDS Research and Interventions
- Air Quality and Health Impacts
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- Free Radicals and Antioxidants
- Genomics and Chromatin Dynamics
- Protein Degradation and Inhibitors
- Peroxisome Proliferator-Activated Receptors
- Cancer Mechanisms and Therapy
- Cardiac tumors and thrombi
- Inflammatory mediators and NSAID effects
- Central Venous Catheters and Hemodialysis
- Cancer-related molecular mechanisms research
- Reconstructive Surgery and Microvascular Techniques
- Viral Infections and Outbreaks Research
- Circular RNAs in diseases
- Suicide and Self-Harm Studies
The Military General Hospital of Beijing PLA
2010-2024
China Pharmaceutical University
2023
Chinese Center For Disease Control and Prevention
2010-2022
Chinese PLA General Hospital
2020
Institute of Biophysics
2020
Chinese Academy of Sciences
2020
University of Chinese Academy of Sciences
2020
Thoracic Surgery Foundation
2015
Zhengzhou University
2006-2013
Sichuan University
2007
: China is at its most important stage of air pollution control. Research on the association between pollutants and human health very necessary. The purpose this study was to evaluate PM
China began to carry out fine particulate matter (PM2.5) monitoring in 2013 and the amount of related research is low, especially areas with lighter air pollution. This study aims explore association between PM2.5 cardiovascular disease (CVD), ischemic heart (IHD) cerebral vascular (EVD) mortality pollution.Data on resident mortality, pollution meteorology Shenzhen during 2013⁻2015 were collected analyzed using semi-parametric generalized additive models (GAM) Poisson distribution time...
Monoubiquitination at lysine 119 of histone H2A (ubH2A) is a prevalent post-translational modification that associated with gene repression in the context chromatin. However, direct function ubH2A on nucleosome poorly understood. Here we identified effect using single-molecule magnetic tweezers. We revealed stabilizes by blocking peeling DNA from octamer. Each reinforces one-half outer wrap and introduces robust asymmetry for unfolding. Furthermore, real-time deubiquitination process...
Mammalian STE20-like kinase 1 (Mst1) is well recognized as a major tumor suppressor in cancer development, growth, metabolic reprogramming, metastasis, cell death and recurrence. However, the roles of Mst1 non-small lung (NSCLC) A549 phenotypic alterations remain to be elucidated. The present study aimed explore functional role underlying mechanisms with regards proliferation, migration apoptosis; this focused on mitochondrial homeostasis Rho-associated coiled-coil containing protein...
Background In October 2016, a senior high school student was diagnosed with sputum-smear positive [SS(+)] pulmonary tuberculosis (TB). We conducted an investigation of outbreak in the school, including among students and teachers latent TB, who we followed until July 2019. Methods defined TB infection (LTBI) as tuberculin skin test (TST) induration 15mm or larger; probable chest radiograph indicative plus productive cough/hemoptysis for at least 2 weeks, TST confirmed two more sputum smears...
The objective of this study was to investigate the antioxidant activity, chemical constituents, and structure-activity relationship from flowers Rosa chinensis Jacq. activity different polar solvent extracts were assayed by a 1,1-diphenyl-2-picrylhydrazyl scavenging experiment. extract with strongest capacity further isolated purified column chromatography. structures compounds elucidated on basis spectral analysis physiochemical properties. these experiment ascorbic acid chosen as positive...
Long noncoding RNA (lncRNA) plays a critical role in initiating lung cancer. This study aims to research the function and mechanism of lncRNA HIF1A-AS2 regulating non-small cell cancer (NSCLC) progression.qRT-PCR was used analyze gene expression. The CCK-8 assay performed detect proliferation. Transwell conducted examine migration invasion. A Caspase3 activity detection kit utilized apoptosis. luciferase reporter carried out interactions HIF1A-AS2, miR-153-5p S100A14.HIF1A-AS2 expression...
All-trans retinoic acid (atRA), a metabolite of vitamin A, is essential for embryonic development. Thus the spatial and temporal dispersal RA must be tightly controlled. Previous studies show that excessive atRA led to growth inhibition p21 accumulation in mouse palatal mesenchymal (MEPM) cells. We reported here identification as required mediator during atRA-induced inhibition. caused G1 arrest cell cycle with an increase proportion cells G0/G1 decrease S phase. In addition marked effect on...
Objective: To know the situation of extramarital sexual behaviors and HIV infection in middle-aged elderly people Chongqing, provide reference for AIDS prevention treatment. Methods: From October to December 2017, a multi-stage sampling method was used recruit middleaged aged ≥50 years who lived Dazu Hechuan districts Chongqing at least one year, with sample size 410. Face-to-face questionnaires survey antibody test were conducted. Results: A total 408 surveyed, including 313 males 95...
The Nuss procedure has become a major alternative operation for patients with pectus excavatum (PE).We report case of 27-year-old man PE who developed thoracic outlet syndrome (TOS) after the procedure. patient showed clinical symptoms brachial plexus compression.Further evaluation demonstrated narrowed space between first rib and anterior scalene muscle compressing vessels.Nerve nourishing medicine rehabilitation exercising were taken to restore strength.Several months later,...
The prognosis of postoperatively recurred malignant schwannoma is poor and there no effective treatment. We had a patient who was found to have large intrathoracic tumor 1 year after surgery could not tolerate an operation for the second time. then decided evaluate synergistic effect recombinant adenovirus-p53 (rAd-p53) combined with radiotherapy patient. rAd-p53 injected intratumorally twice week before radiotherapy, total 10 times, over course Radiotherapy followed gene therapy at five...
To provide a scientific basis for identifying the causes of an outbreak and providing preventive control measures to prevent recurrence similar outbreaks.
Objective To understand the current status,type,and effect of training programs conducted by Health Bureau and CDC in China.Methods One person each province was selected from China field epidemiology network designated as contact who responsible for collecting information practical lasting at least 6 months staff public health emergency infectious disease control October 2001 to 2010.Questionnaire including basic condition,organization management,training design,faculty condition,trainee...
公益广告是指不以盈利为目的,为社会公众切身利益和社会风尚服务的广告.而健康相关的公益广告不仅是传播健康信息的有效途径,也是健康教育的重要手段.为了解北京市主要公交线路站点健康公益广告发布现况及存在的问题,2012年11月21日至12月10日开展了现场调查.1.对象与方法:选取北京市环绕市区的二、三环线及东西南北走向行驶穿越城区主要公交线路站点的广告牌为研究对象.广告牌是指公交车站点旁以展示牌为载体形式的构筑物;健康广告是指内容涉及有益提升大众健康的广告;广告牌损坏是指展示牌基础组成受损致使不能展示广告内容.对选定的公交线路所有沿线站点进行现场调查,记录各站点有无广告牌、广告牌内容及破损情况,对有健康相关的公益广告牌均现场拍照,确保调查质量.数据采用Epi Info软件进行统计分析,采用x2检验,分析两组间的统计学差异,P＜0.05为差异有统计学意义. 关键词：健康公益广告;公交车站;现场调查